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| 1 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 2 | 中年直立性低血压和晕倒的风险显示文摘每年有1/3老年人晕倒。直立性低血压(orthostatic hypotension,OH)被认为是晕倒的重要危险因素之一,但先前对此研究的结论并不一致。 | Juraschek SP Daya N Appel LJ Miller ER Windham BG Pompeii L Griswold ME Kucharska-Newton A Selvin E 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，10： | 3 |
| 3 | lnterrater reliability of APACHE Ⅱ scores for medical-surgical intensive care patients: a prospective blinded study 显示文摘 | Kho ME McDonald E Stratford PW | 2007 | Am J Crit Care2007，16，4： | 1 |
| 4 | The diagnostic and predictive validity of the renfrew bus story显示文摘 | Pankratz ME Plante E Vance R | 2007 | Lang Speech Hear Serv Sch2007，38，4： | 1 |
| 5 | Antioxidant enzyme activities and malondialdehyde levels related to aging显示文摘 | Kanbak G Sunal E | 2001 | Clin Chim Acta2001，305，1： | 1 |
| 6 | Effects of residual and reapplied biosolids on performance and mineral status of grazing beef steers显示文摘 | Tiffany M E Me Dowell L R O'connor G A etal | 2002 | Journal of Animal Science2002，80，： | 1 |
| 7 | Lonidamine transiently affects spermatogenesis in pubertal CD1 mice显示文摘 | Traina ME Guarino M Urbani E | 2005 | Contraception2005，72，4： | 1 |
| 8 | Ferbrile reactions to platelet transfusion: the effect of increased IL-6 levels in concentrates prepared by the platelet- rich plasma mothod显示文摘 | Muller L Wonters E Petermans ME | 1998 | Transfusion1998，40，7： | 1 |
| 9 | Photodynamic therapy induces rapid cell death by apoptosis in LS178Y mouse lymphoma cells显示文摘 | Agarwal ML Clay ME Harvey E J | 1991 | Cancer Res1991，51，21： | 1 |
| 10 | The results of frozen section,touch preparation,and cytological smear are comparable for intraoperative examination of sentinel lymph nodes: a study in 133 breast cancer patients 显示文摘 | Brogi E Torres ME Tan LL | 2005 | Ann Surg Oncol2005，12，2： | 1 |
| 11 | Quality of different chondroitin sulfate preparations in relation to their therapeutic activity显示文摘 | MEERW ME BOUT J V D | 2009 | J Pharm Pharmacol2009，61，10： | 1 |
| 12 | Mechanoreceptors in the human medial meniscus显示文摘 | Zimny ME Albright DJ Dabezies E | 1988 | Acta Anat(Basel)1988，133，1： | 1 |
| 13 | Local Immune Regulation of Mucosal Inflammation by Tacroli- mus显示文摘 | Lambers ME Kuipers E J van Dieren JM | 2010 | Digest Dis Sci2010，55，9： | 1 |
| 14 | Dying with cancer: patients function, symp-toms ,and care preferences as death approaches 显示文摘 | Me Carthy E | 2000 | JAGS2000，48，5： | 1 |
| 15 | Venous access in haemophilic chil-drenxhoice and management显示文摘 | Santagostino E Mancuso ME | 2010 | Haemophilia2010，16，1： | 1 |
| 16 | Turkish version of the Omaha System:its use in practice-based family nursing education nurse education today显示文摘 | Semra E Nihal ME | 2006 | Nurse Education Today2006，26，： | 1 |
| 17 | The effect of surgery in encephalopathy with electrical status epileticus during sleep显示文摘 | Peltola ME Liukkomen E Granstrm ML | 2011 | Epilepsy2011，52，3： | 1 |
| 18 | Hope and related variables in I- talian cancer patients 显示文摘 | Vellone E Rega ME Galletti C | 2006 | Can Nurs2006，29，5： | 1 |
| 19 | Astrocytes produce dendritic cell-attracting chemokines in vitro and in multiple sclerosis lesions 显示文摘 | Ambrosini E Remoli ME Giacomini E | 2005 | J Neuropathol Exp Neurol2005，64，8： | 1 |
| 20 | Gastrointestinal surgery in the elderly 显示文摘 | Micheal E Zenilman ME | 1996 | Prob Gen Surg1996，13，3： | 1 |
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