|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A Host KH RNA-Binding Protein Is a Susceptibility Factor Targeted by an RXLR Effector to Promote Late Blight Disease显示文摘植物病原体交付改变主人过程创造对殖民导致的环境的受动器蛋白质。注意集中了于识别受动器的目标并且他们的操作怎么便于疾病。从土豆老家病原体 Phytophthora infestans 的 RXLR 受动器 Pi04089 在主人原子核积累并且当短暂地在 planta 表示了时,提高殖民。它的原子本地化为提高的 P.infestans 殖民被要求。Pi04089 与通常认为的土豆 K 相同(KH ) 在酵母并且在 planta 交往 RNA 有约束力的蛋白质, StKRBP1。Pi04089 和 StKRBP1 的合作本地化,和在他们之间的双分子的荧光互补,显示他们在原子点缀联系。当它与 Pi04089 被共同表示时, StKRBP1 蛋白质层次增加了。确实, StKRBP1 的如此的累积被病原体在叶殖民的第一天也观察。显著地, StKRBP1 的 overexpression 显著地提高 P.infestans 感染。当与受动器共同表示时,到在 StKRBP1 的所有三个 KH 领域的 GDDG 的核苷酸绑定主题 GxxG 的变化与 Pi04089,它到原子点缀的本地化,和它的增加的累积废除它的相互作用。而且,变异的 StKRBP1 蛋白质不再由 P.infestans 提高叶殖民,暗示那核苷酸绑定多半为这项活动被要求。我们因此主张 StKRBP1 能被认为是一个危险性因素,因为它的活动对病原体有益。 | Xiaodan Wang Petra Boevink Hazel McLellan Miles Armstrong Tatyana Bukh-arova Zhiwei Qin Paul R.J. Birch | 2015 | Molecular Plant2015，8，9： | 15 |
| 2 | All Roads Lead to Susceptibility: The Many Modes of Action of Fungal and Oomycete Intracellular Effectors显示文摘The ability to secrete effector proteins that can enter plant cells and manipulate host processes is a key determinant of what makes a successful plant pathogen.Here,we review intracellular effectors from filamentous(fungal and oomycete)phytopathogens and the host proteins and processes that are targeted to promote disease.We cover contrasting virulence strategies and effector modes of action.Filamentous pathogen effectors alter the fates of host proteins that they target,changing their stability,their activity,their location,and the protein partners with which they interact.Some effectors inhibit target activity,whereas others enhance or utilize it,and some target multiple host proteins.We discuss the emerging topic of effectors that target negative regulators of immunity or other plant proteins with activities that support susceptibility.We also highlight the commonly targeted host proteins that are manipulated by effectors from multiple pathogens,including those representing different kingdoms of life. | Qin He Hazel McLellan Petra C.Boevink Paul R.J.Birch | 2020 | Plant Communications2020，1，4： | 3 |
| 3 | Pan-cancer analysis of somatic mutations across 21 neuroendocrine tumor types显示文摘 | Yanan Cao Weiwei Zhou Lin Li Jiaqian Wang Zhibo Gao Yiran Jiang Xiuli Jiang Aijing Shan Matthew H. Bailey Kuan-lin Huang Sam Q. Sun Michael D. McLellan Beifang Niu Weiqing Wang Li Ding Guang Ning | 2018 | Cell Research2018，28，5： | 3 |
| 4 | The Origin and Evolution of Mutations in Acute Myeloid Leukemia显示文摘 | John S. Welch Timothy J. Ley Daniel C. Link Christopher A. Miller David E. Larson Daniel C. Koboldt Lukas D. Wartman Tamara L. Lamprecht Fulu Liu Jun Xia Cyriac Kandoth Robert S. Fulton Michael D. McLellan David J. Dooling John W. Wallis Ken Chen Christop | 2012 | Cell2012，，2： | 3 |
| 5 | Oomycetes Seek Help from the Plant:Phytophthora infestans Effectors Target Host Susceptibility Factors显示文摘 | Petra C. Boevink Hazel McLellan Eleanor M. Gilroy Shaista Naqvi Qin He Lina Yang Xiaodan Wang Dionne Turnbull Miles R. Armstrong Zhendong Tian Paul R.J. Birch | 2016 | Molecular Plant2016，9，5： | 2 |
| 6 | Study of the impacts of upstream natural gas market reform in China on infrastructure deployment and social welfare using an SVM-based rolling horizon stochastic game analysis显示文摘Natural gas is expected to play a much more important role in China in future decades, and market reform is crucial for its rapid market penetration. At present, the main gas fields, pipelines and liquefied natural gas(LNG) infrastructure are mainly monopolized by large state-owned companies, and one of the important market reform policies is to open up LNG import rights to smaller private companies and traders. Therefore, in the present study, a game theoretical model is proposed to analyze and compare the impacts of different market structures on infrastructure deployment and social welfare. Moreover, a support vector machine-based rolling horizon stochastic method is adopted in the model to simulate real LNG price fluctuations. Four market reform scenarios are proposed considering different policies such as business separation, third-party access(TPA) and their combinations. The results indicate that, with third-party access(TPA)entrance into the LNG market, the construction of LNG infrastructure will be promoted and more gas will be provided at lower prices, and thus the total social welfare will be improved greatly. | Yan Li Ge Wang Benjamin Mclellan Si-Yuan Chen Qi Zhang | 2018 | Petroleum Science2018，15，4： | 2 |
| 7 | Robust mult-loop PID controller design-a successive semi-definite programming approach显示文摘 | BAO J FORBES J F MCLELLAN P J | 1999 | Ind Eng Chem Process Des Dev1999，38，： | 2 |
| 8 | P250 Central nervous system (CNS) complications of ear nose throat (ENT) infections – case series显示文摘 | N. Vora P.D. Eunson K.K. Tallur A. Baxter R.A. Minns A.J.W. Steers L. Myles A.E. McLellan | 2009 | European Journal of Paediatric Neurology2009，，： | 2 |
| 9 | The effects of psychosocial services in substance abuse treatment 显示文摘 | McLellan AT Amdt IO Metzger DS | 1993 | JAMA1993，269，15： | 1 |
| 10 | The relative effects of deformation and thermal advection on fluid pathways in basin-related mineralization显示文摘 | Mclellan J G Oliver N H S Hobbs B E | 2006 | Journal of Geochemical Exploration2006，89，： | 1 |
| 11 | Synthesis of palladium icosahedra with twinned structure by blocking oxidative etching with citric acid or citrate ions显示文摘 | Xiong Y McLellan J M Yin Y | 2007 | Angew Chem Int Ed2007，46，5： | 1 |
| 12 | Heat strain in protective clothing following hot- wet or hot - dry heat acclimation 显示文摘 | McLellan T M Aoyagi Y | 1996 | Can J Appl Physiol1996，21，2： | 1 |
| 13 | Glutathione and glutathione-dependent enzymes represent a co-ordinately defence against oxidative stress显示文摘 | HAYES JD MCLELLAN LI | 1999 | Free Radio Res1999，31，： | 1 |
| 14 | Oxygen-induced retinopathy in the mouse 显示文摘 | Smith LE Wesolowski E McLellan A | 1994 | Invest Ophthalmol Vis Sci1994，35，： | 1 |
| 15 | The nurse - patient relationship will prove key to effective medication adherence 显示文摘 | McLellan A | 2009 | Nurs Times2009，105，3： | 1 |
| 16 | Myths about the treatment of addiction显示文摘 | O’Brien CP McLellan AT | 1996 | Lancet1996，347，8996： | 1 |
| 17 | An improved diagnostic evaluation instrument for substance abuse patient: the addiction severity index 显示文摘 | McLellan AT Luborsky L Woody G | 1980 | The Journal of Nervous and Mental Disease1980，168，1： | 1 |
| 18 | The fifth edition of the addiction severity index 显示文摘 | McLellan AT Kushner H Metzger D | 1992 | J Subst Abuse Treat1992，9，3： | 1 |
| 19 | An improved diag-nostic evaluation instrument for substance abuse patients:The Addiction Severity Index显示文摘 | McLellan AT Luborsky L Woody G | 1980 | J Nerv Ment Dis1980，168，： | 1 |
| 20 | Oxygen -inducedretinopathy in the mouse显示文摘 | Smith LE Wesolowski E McLellan A | 1994 | Invest Ophthalmol Vis Sci1994，351，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员