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| 1 | Celiac disease:Management of persistent symptoms in patients on a gluten-free diet显示文摘AIM:To investigate all patients referred to our center with non-responsive celiac disease (NRCD),to establish a cause for their continued symptoms.METHODS:We assessed all patients referred to our center with non-responsive celiac disease over an 18-mo period.These individuals were investigated to establish the eitiology of their continued symptoms.The patients were first seen in clinic where a thorough history and examination were performed with routine blood work including tissue transglutaminase antibody measurement.They were also referred to a specialist gastroenterology dietician to try to identift any lapses in the diet and sources of hidden gluten ingestion.A repeat small intestinal biopsy was also performed and compared to biopsies from the referring hospital where possible.Colonoscopy,lactulose hydrogen breath testing,pancreolauryl testing and computed tomography scan of the abdomen were undertaken if the symptoms persisted.Their clinical progress was followed over a minimum of 2 years.RESULTS:One hundred and twelve consecutive patients were referred with NRCD.Twelve were found not to have celiac disease (CD).Of the remaining 100 patients,45% were not adequately adhering to a strict gluten-free diet,with 24 (53%) found to be inadvertently ingesting gluten,and 21 (47%) admitting noncompliance.Microscopic colitis was diagnosed in 12% and small bowel bacterial overgrowth in 9%.Refractory CD was diagnosed in 9%.Three of these were diagnosed with intestinal lymphoma.After 2 years,78 patients remained well,eight had continuing symptoms,and four had died.CONCLUSION:In individuals with NRCD,a remediable cause can be found in 90%:with continued gluten ingestion as the leading cause.We propose an algorithm for investigation. | David H Dewar Suzanne C Donnelly Simon D McLaughlin Matthew W Johnson H Julia Ellis Paul J Ciclitira | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 2 | Building in vitro models of organs显示文摘 | Suuronen EJ Sheardown H Newman KD McLaughlin CR Griffith M | 2005 | Int Rev Cyto2005，244，： | 1 |
| 3 | High diversity andwidespread occurrence of mitotic spore mats in ectomycorrhizalPezizales显示文摘 | Healy R A Smith M E Bonito G M Pfister D H Ge Z W Guevara G G ’ Williams G Stafford K Kumar L Lee T HobartC Trappe J Vilgalys R McLaughlin D J | 2013 | Molecular Ecology2013，22，： | 1 |
| 4 | The estimation of distances between specific backbone-labeled sites in DNA using fluorescence resonance energy transfer显示文摘 | Ozaki H Mclaughlin L W | 1992 | Nucleic Acids Res1992，20，： | 1 |
| 5 | Calibrating WEPP model parameters for erosion predictionon construction Sites 显示文摘 | MOORE A D MCLAUGHLIN R A MITASOVA H | 2007 | Transactions of the ASABE2007，50，2： | 1 |
| 6 | From CANtheory to DeviceNet practice 显示文摘 | McLaughlin R T | 1997 | Electronic Engineering1997，71，874： | 1 |
| 7 | The estimation of distances between specific backbone-labeled sites in DNA using fluo- rescence resonance energy transfer显示文摘 | Qzaki H McLaughlin L W | 1992 | Nucleic Acids Res1992，20，19： | 1 |
| 8 | Nonlinear behavior of an elastomeric lag damper undergoing dual-frequency motion and its effect on rotor dynamics显示文摘 | Felker F F Lau B H McLaughlin S | 1987 | Journal of the American Helicopter Society1987，34，4： | 1 |
| 9 | Immuno contraceptive effects on female rabbits infected with recombi nant myxoma virus expressing rabbit ZP2 or ZP3 显示文摘 | Mackenzie S M Mclaughlin E A Perkins H D | 2006 | Biology of Reproduction2006，74，3： | 1 |
| 10 | Bioaugmentation of activated sludge with two Pseudomonas putida strains for the degradation of 4-chlorophenol显示文摘 | McLaughlin H Farrell A Quihy B | 2006 | J Environm Sci Heal Part A2006，41，： | 1 |
| 11 | Job performance deficits due to depression 显示文摘 | Adler D A McLaughlin T J Rogers W H | 2006 | Am J Psychiatry2006，163，： | 1 |
| 12 | Prediction of zinc, cadmium, lead and copper availability to wheat in contaminated soils using chemical speciation, diffusive gradients in thin film, extraction and isotopic dilution techniques显示文摘 | Nolan AL Zhang H McLaughlin MJ | 2005 | Journal of Environment Quality2005，34，2： | 1 |
| 13 | The estimation of distances between specific backbone-labeled sites in DNA using fluorescence resonance energy transfer显示文摘 | OZAKI H MCLAUGHLIN L W | 1992 | Nucleic Acids Res1992，20，： | 1 |
| 14 | Development of aVolatile Amine Sensor for the Monitoring of Fish Spoilage 显示文摘 | Pacquit A Lau K T McLaughlin H | 2006 | Talanta2006，69，： | 1 |
| 15 | Nonlinear behavior of an elastomeric lag damper undergoing dual-frequency motion and its effect on rotor dynamics显示文摘 | Felker F F Lau B H McLaughlin S | 1987 | Journal of the American Helicopter Society1987，34，4： | 1 |
| 16 | Outcomes of muhidrug-resistant tuberculosis treatment with early initiation of antiretroviral therapy for HIV co-infected patients in Lesotho 显示文摘 | Satti H McLaughlin MM Hedt-Gauthier B | 2012 | PLoS One2012，7，46： | 1 |
| 17 | Endoscopic septoplasty:indications,technique,and results显示文摘 | HWANG P H MCLAUGHLIN R B LANZA D C etal | 1999 | Otolaryngol Head Neck Surg1999，120，： | 1 |
| 18 | Proton pump inhibitors and risk of gastric cancer: a population-based cohort study 显示文摘 | Poulsen A H christensen S McLaughlin J K | 2009 | Br J Cancer2009，100，9： | 1 |
| 19 | Brownian diffusion of submicrometer particles in the viscous sublayer显示文摘 | OUNIS H AHMADI G MCLAUGHLIN J B | 1991 | Journal of Colloid and Interface Science1991，143，1： | 1 |
| 20 | Hydrologic data assimilation with the ensemble Kalman filter显示文摘 | Reichle R H McLaughlin D B Entekhabi D | 2002 | Monthly Weather Review2002，130，： | 1 |
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