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| 1 | Prognostic value of M30/M65 for outcome of hepatitis B virus-related acute-on-chronic liver failure显示文摘AIM:To determine the prognostic value of circulating indicators of cell death in acute-on-chronic liver failure(ACLF)patients with chronic hepatitis B virus(HBV)infection as the single etiology.METHODS:Full length and caspase cleaved cytokeratin 18(detected as M65 and M30 antigens)represent circulating indicators of necrosis and apoptosis.M65and M30 were identified by enzyme-linked immunosorbent assay in 169 subjects including healthy controls(n=33),patients with chronic hepatitis B(CHB,n=55)and patients with ACLF(n=81).According to the 3-mo survival period,ACLF patients were defined as having spontaneous recovery(n=33)and non-spontaneous recovery which included deceased patients and those who required liver transplantation(n=48).RESULTS:Both biomarker levels significantly increased gradually as liver disease progressed(for M65:P<0.001 for all;for M30:control vs CHB,P=0.072;others:P<0.001 for all).In contrast,the M30/M65 ratio was significantly higher in controls compared with CHB patients(P=0.010)or ACLF patients(P<0.001).In addition,the area under receiver operating characteristic curve(AUC)analysis demonstrated that both biomarkers had diagnostic value(AUC≥0.80)in identifying ACLF from CHB patients.Interestingly,it is worth noting that the M30/M65 ratio was significantly different between spontaneous and non-spontaneous recovery in ACLF patients(P=0.032).The prognostic value of the M30/M65 ratio was compared with the Model for End-Stage Liver Disease(MELD)and Child-Pugh scores at the 3-mo survival period,the AUC of the M30/M65ratio was 0.66 with a sensitivity of 52.9%and the highest specificity of 92.6%(MELD:AUC=0.71;sensitivity,79.4%;specificity,63.0%;Child-Pugh:AUC=0.77;sensitivity,61.8%;specificity,88.9%).CONCLUSION:M65 and M30 are strongly associated with liver disease severity.The M30/M65 ratio may be a potential prognostic marker for spontaneous recovery in patients with HBV-related ACLF. | Su-Jun Zheng Shuang Liu Mei Liu Malcolm A McCrae Jun-Feng Li Yuan-Ping Han Chun-Hui Xu Feng Ren Yu Chen Zhong-Ping Duan | 2014 | World Journal of Gastroenterology2014，20，9： | 13 |
| 2 | An Introduction to the Five-factor Model and its Applications 显示文摘 | McCrae R R Costa P T | 1992 | Journal of Personality1992，60，2： | 1 |
| 3 | The Five-factor Personality Inventory as a measure of the Five-factor Model:Belgian,American, and Hungarian comparisons with the NEO-PI-R显示文摘 | De Fruyt F McCrae R R Szirmak Z | 2004 | Assessment2004，11，3： | 1 |
| 4 | Pregnancy-associated thrombocytopenia: pathogenesis and management 显示文摘 | McCrae K R Samuels P Schreiber A D | 1992 | Blood1992，80，： | 1 |
| 5 | Development of a high-throughput human rhinovirus infectivity cell-based assay for identifying antiviral compounds显示文摘 | Phillips T Jenkinson L McCrae C | 2011 | J Virol Methods2011，173，2： | 1 |
| 6 | The cellulase of Penicillium-pinophillum synergism between enzyme components in solubilizing cellulose with special reference to the involvement of two immunologically distinct cellobiohydrolases 显示文摘 | Wood T M Mccrae S L | 1986 | Biochem J1986，234，1： | 1 |
| 7 | Stability and Change in Personality Assessment: The Revised NEO Personality Inventory in the Year 2000显示文摘 | Paul T. Costa Robert R. McCrae | 1997 | Journal of Personality Assessment1997，，1： | 1 |
| 8 | The nature of the polypeptide encoded by each of the 10 double-stranded RNA segments of reovirus type 3 显示文摘 | McCrae M A Joklik W K | 1978 | Virology1978，89，2： | 1 |
| 9 | Influence of extraversion and neuroticism on subjective well-being: happy and unhappy people显示文摘 | Costa P T McCrae R R | 1980 | Journal of personality and social psychology1980，38，4： | 1 |
| 10 | The mechanism of fungal cellulase action, synergism between enzyme components of Penicillium pinophilum cellulase in solubilizing hydrogen-bound ordered cellulase显示文摘 | Wood T M Mccrae S L Bhat K M | 1989 | Biochem J1989，260，： | 1 |
| 11 | Late-life comorbid insomnia:diagnosis and treat-ment显示文摘 | McCrae CS | 2009 | Am J Manag Care2009，，： | 1 |
| 12 | Measurement of plasma fibrin D-dimer levels with the use of a monoclonal antibody coupled to latex beads显示文摘 | Greenberg CS Devine DV mcCrae KM | 1987 | Am J Clin Pathol1987，87，1： | 1 |
| 13 | Adding liebe und arbeit: the full five-factor model and well-being 显示文摘 | McCrae RR Costa PT | 1991 | Pers Soc Psychol Bull1991，17，2： | 1 |
| 14 | Validation of the five - factor model of personality across instruments and observers 显示文摘 | MCCRAE R R COSTA P T JR | 1987 | J Pers Soc Psychol1987，52，1： | 1 |
| 15 | Four ways five factors are basic 显示文摘 | Costa P T McCrae R R | 1992 | Personality and Individual Differences1992，13，： | 1 |
| 16 | Updating norman's adequate taxonomy' : Intelligence and personality dimensions in natural language and in questionnaires显示文摘 | MCCRAE R R COSTA JR P T | 1985 | J Personality Soc Psyehol1985，，49： | 1 |
| 17 | Influence of extraversion and neuroticism on subjective well-being:happy and unhappy people显示文摘 | Costa P T McCrae R R | | 0，，04： | 1 |
| 18 | Human nature and culture: A trait perspective显示文摘 | Robert R McCrae | 2004 | Journal of Research in Personality2004，38，1： | 1 |
| 19 | Yellow fever anti Zika virus epizootics and euzootics in Uganda显示文摘 | McCrae AW Kirya BG | 1982 | Trans R Soc Trop Med ttyg1982，76，4： | 1 |
| 20 | Helicobacter pylori and ITP:many questions,few answers显示文摘 | McCrae R | 2004 | Blood2004，103，3： | 1 |
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