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| 1 | Protein tyrosine phosphatase non-receptor type 2 andinflammatory bowel disease显示文摘Genome wide association studies have associated single nucleotide polymorphisms within the gene locus encoding protein tyrosine phosphatase non-receptor type 2(PTPN2) with the onset of inflammatory bowel disease(IBD) and other inflammatory disorders. Expression of PTPN2 is enhanced in actively inflamed intestinal tissue featuring a marked up-regulation in intestinal epithelial cells. PTPN2 deficient mice suffer from severe intestinal and systemic inflammation and display aberrant innate and adaptive immune responses. In particular, PTPN2 is involved in the regulation of inflammatory signalling cascades, and critical for protecting intestinal epithelial barrier function, regulating innate and adaptive immune responses, and finally for maintaining intestinal homeostasis. On one hand, dysfunction of PTPN2 has drastic effects on innate host defence mechanisms, including increased secretion of pro-inflammatory cytokines, limited autophagosome formation in response to invading pathogens, and disruption of the intestinal epithelial barrier. On the other hand, PTPN2 function is crucial for controlling adaptive immune functions, by regulating T cell proliferation and differentiation as well as maintaining T cell tolerance. In this way, dysfunction of PTPN2 contributes to the manifestation of IBD. The aim of this review is to present an overview of recent findings on the role of PTPN2 in intestinal homeostasis and the impact of dysfunctional PTPN2 on intestinal inflammation. | Marianne R Spalinger Declan F McCole Gerhard Rogler Michael Scharl | 2016 | World Journal of Gastroenterology2016，22，3： | 4 |
| 2 | Epithelial transport and gut barrier function in colitis 显示文摘 | McCole DF Barrett KE | 2003 | Curr Opin Gastroenterol2003，19，6： | 1 |
| 3 | VO2max is associated with ACE genotype in postmenopausal women显示文摘 | Hagbereg J M McCole S D Wilund K R | 1998 | J Appl Physiol1998，85，5： | 1 |
| 4 | Utilization of glycogen but not plasma glucose is reduced in individuals with NIDDM during mild-intensity exercise显示文摘 | Hagberg JM McCole SD | 1996 | J Appl Physiol1996，81，5： | 1 |
| 5 | Utilization of glycogen but not plasma glucose is reduced in individuals with NIDDM during mild-intensity exercise显示文摘 | 2olberg SR Hagberg JM McCole SD | 1996 | J Appl Physiol1996，81，5： | 1 |
| 6 | Obesitygene variant and elite endurance performance显示文摘 | Moore Geoffrey E Shuldiner Alan R Zmuda J0seph M Ferrell Robert E Mccole Steve D Hagberg James M | 2001 | Metabolism Clinical and Experimental2001，50，12： | 1 |
| 7 | Understanding online customer repurchasing intention and the mediating role of trust-an empirical investigation in two developed countries显示文摘 | Qureshi I Fang Y Ramesy E McCole P Ibboston P Compeau D | 2009 | European Journal of Information Systems2009，18，3： | 1 |
| 8 | Regulation of epithelial barrier function by the inflammatory bowel disease candidate gene, PTPN2显示文摘 | McCole DF | 2012 | Ann N Y Acad Sci2012，1257，： | 1 |
| 9 | Ionization-gating-induced nonlinear phase accumulation in spectrally resolved transient birefringence measurements at 400 nm显示文摘 | Odhner J H Romanov D A McCole E T | | 0，，06： | 1 |
| 10 | A molecular analysis of neurogenic placode and cranial sensory ganglion development in the shark,Scyliorhinus canicula显示文摘 | O'Neill P McCole R B Baker C V | 2007 | Developmental Biology2007，304，1： | 1 |
| 11 | Seasonal water use patterns of Juniperus ashei on the Edwards Plateau,Texas,based on stable isotopes in water显示文摘 | McCole A A Stern L A | 2007 | Journal of Hydrology2007，342，3： | 1 |
| 12 | Hypertonic salinereduces neutrophil-epithelial interactions in vitro and guttissue damage in a mouse model of colitis 显示文摘 | Tillinger W McCole D F Keely S J | 2008 | Am J Physi-ol Regul Integr Comp Physiol2008，295，6： | 1 |
| 13 | Varied role of the gut epithelium in mucosal homeostasis显示文摘 | Declan F McCole Kim E Barrett | 2007 | Current Opinion in Gastroenterology2007，，6： | 1 |
| 14 | Pathogenesis of Cryptosporidium parvum infection 显示文摘 | Laurent F McCole D Eckmann L | 1999 | Microbes and Infection1999，2，： | 1 |
| 15 | Epithelial transport and gut barrier function in colitis 显示文摘 | McCole DF Barrett-KE | 2003 | Curt Opin Gastroenterol2003，19，6： | 1 |
| 16 | Moderate physical activity is associated with higher bone mineral density in postmenopausal women显示文摘 | Hagberg J M Zmuda J M McCole S D | 2001 | J Am Geriatr Soc2001，，： | 1 |
| 17 | Hypertonic saline reduces neutriphil-epithelial interactions in vitro and gut tissue damage in a mouse model of colitis显示文摘 | Tillinger W McCole DF Keely SJ | 2008 | Am J Physiol Regul Integr Comp Phys- io12008，295，6： | 1 |
| 18 | Hypertonic saline reduces neutrophil-epithelial interactions in vitro and gut tissue damage in a mouse model of colitis显示文摘 | Tillinger W McCole DF Keely SJ | 2008 | Am J Physiol Regul Integr Comp Physiol2008，295，6： | 1 |
| 19 | Hypertonic saline re- duces neutrophil-epithelial interactions in vitro and gut tissue damage in a mouse model of colitis显示文摘 | Tillinger W McCole DF Keely SJ | 2008 | Am J Physiol Regul Integr Comp Physiol2008，295，6： | 1 |
| 20 | The Role of Trust for Electronic Commerce in Services显示文摘 | McCole P | 2002 | International Journal of Contemporary Hospitality Management2002，14，2： | 1 |
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