|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | Atmosphere-ionosphere response to the M9 Tohoku earthquake revealed by multiinstrument space-borne and ground observations:Preliminary results显示文摘We retrospectively analyzed the temporal and spatial variations of four different physical parameters characterizing the state of the atmosphere and ionosphere several days before the M9 Tohoku,Japan earthquake of March 11,2011.The data include outgoing long wave radiation(OLR),GPS/TEC,lower Earth orbit ionospheric tomography and critical frequency foF2.Our first results show that on March 7th a rapid increase of emitted infrared radiation was observed from the satellite data and an anomaly developed near the epicenter.The GPS/TEC data indicate an increase and variation in electron density reaching a maximum value on March 8.Starting from this day in the lower ionosphere also there was confirmed an abnormal TEC variation over the epicenter.From March 3 to 11 a large increase in electron concentration was recorded at all four Japanese ground-based ionosondes,which returned to normal after the main earthquake.The joint preliminary analysis of atmospheric and ionospheric parameters during the M9 Tohoku,Japan earthquake has revealed the presence of related variations of these parameters implying their connection with the earthquake process.This study may lead to a better understanding of the response of the atmosphere/ionosphere to the great Tohoku earthquake. | Dimitar Ouzounov Sergey Pulinets Alexey Romanov Alexander Romanov Konstantin Tsybulya Dmitri Davidenko Menas Kafatos Patrick Taylor | 2011 | Earthquake Science2011，24，6： | 7 |
| 3 | Coal-gas interaction: implications of changes in texture and porosity显示文摘 | Vyacheslav N. Romanov Lauren C. Graeser Sinisha A. Jikich Yee Soong Gino A. Irdi | 2016 | International Journal of Coal Science & Technology2016，3，1： | 4 |
| 4 | Risk factors and urinary biomarkers of non-albuminuric and albuminuric chronic kidney disease in patients with type 2 diabetes显示文摘BACKGROUND A number of recent studies indicate a transformation in the natural course of chronic kidney disease(CKD)in type 2 diabetes(T2D)patients:an increasing prevalence of declined renal function without proceeding to the accompanying elevation of albuminuria.It has been suggested that albuminuric and nonalbuminuric CKD patterns could be different in their phenotypes and pathogenic mechanisms.AIM To identify the risk factors and biomarkers of albuminuric and non-albuminuric patterns of CKD in patients with T2D.METHODS Three hundred sixty patients with T2D duration≥10 years were included in this observational cross-sectional study.The associations of a panel of demographic and clinical characteristics,complications,comorbidities,and metabolic and hematology parameters with albuminuric and non-albuminuric CKD patterns were analyzed.The urinary excretion of nephrin and podocin,two podocytespecific markers,and WAP-four-disulfide core domain protein 2(WFDC-2),a marker of tubulointerstitial fibrosis,was determined by ELISA in comparison with healthy controls.RESULTS Non-albuminuric CKD was associated with age≥65 years(P=0.0001),female sex(P=0.04),diabetes duration≥15 years(P=0.0009),and the use of diuretics(P=0.0005).Male sex(P=0.01),smoking(P=0.01),waist-to-hip ratio>1.0(P=0.01)and hemoglobin A1c(HbA1c)>8.0%(P=0.005)were risk factors for elevated albuminuria not accompanied by a decrease in estimated glomerular filtration rate(eGFR).Duration of diabetes≥15 years and the use of calcium channel blockers were risk factors for albuminuria with decreased eGFR(both P=0.01).In multivariate logistic regression analysis,age,HbA1c,female sex and diuretics were significant predictors for reduced eGFR,while waist-to-hip ratio,HbA1c and male sex were associated with elevated urinary albumin-to-creatinine ratio(UACR).Excretion of nephrin and podocin was increased in patients with albuminuria,regardless of decline in renal function(P<0.001),correlating positively with UACR.The urinary excretion of WFDC-2 was markedly higher in men than in women(P<0.000001).Men with T2D demonstrated increased WFDC-2 levels independently of the CKD pattern(all P<0.05).In T2D women,WFDC-2 excretion was increased in those with reduced renal function(P≤0.01),correlating negatively with eGFR.CONCLUSION The data provide further evidence that albuminuric and non-albuminuric CKD phenotypes correspond to different pathways of diabetic kidney disease progression. | Anton I Korbut Vadim V Klimontov Ilya V Vinogradov Vyacheslav V Romanov | 2019 | World Journal of Diabetes2019，10，11： | 3 |
| 5 | 脉冲激光辐照金属材料表面瞬态温度场研究显示文摘建立了脉冲激光辐照金属材料表面的热学模型,通过拉普拉斯变换法求解了热传导方程,得出金属材料在激光辐照下加热和冷却过程瞬态温度场分布的精确解析解。基于Visual C++编程并实现界面化,实现对于具体材料激光辐照下瞬态温度场的预测和分析。并以纯铝的激光熔覆和镁合金的激光熔凝实验为例,验证了瞬态温度场的分布。结果表明,金属材料在一个脉冲时间内温度随激光辐照时间的增加而升高,辐照结束后,表面温度迅速下降,内部温度下降较慢。分析结论与相关实验结果基本吻合,证实了所建模型的合理性。该结论对其它激光表面处理过程具有一定的指导作用。 | 周杰 马增辉 逄熹睿 王红颖 郭作兴 胡建东 王耀民 Romanov,Oleg G. | 2010 | 应用激光2010，30，1： | 3 |
| 6 | Mesenchymal Stem Cells from Human Bone Marrow and Adipose Tissue: Isolation, Characterization, and Differentiation Potentialities显示文摘 | Yu. A. Romanov A. N. Darevskaya N. V. Merzlikina L. B. Buravkova | 2005 | Bulletin of Experimental Biology and Medicine2005，，1： | 2 |
| 7 | 欧亚北部跨大陆交通经济带发展工程(英文)显示文摘跨西伯利亚大铁路的主要作用在于实现欧亚两洲西部和东部的交流。沿西伯利亚大铁路及其分支的交通经济带的形成意义重大。本文揭示了西伯利亚大铁路及其分支以及'一体化的欧亚基础设施系统'这一宏伟工程长远发展的主要特征,描述了西伯利亚大铁路和中国新丝绸之路影响区域的比较特征,提出了欧亚跨大陆板块交通经济带发展中面临的环境问题。研究认为,尽管在欧亚交通领域西伯利亚大铁路会面临一些竞争,但通过促进沿交通走廊区域的可持续发展,新丝绸之路建设将会为参与的国家带来显著的社会经济效益和环境效益,也必然会促进欧亚更密切的区域经济一体化和区域安全。 | Peter BAKLANOV Matvey ROMANOV Vladimir KARAKIN Alexey LANKIN | 2015 | Journal of Resources and Ecology2015，6，2： | 2 |
| 8 | 使用虚拟仪器测量NO_2质量浓度显示文摘空气中NO2浓度的准确可靠测量至关重要。本文所讨论的内容是对利用LabVIEW虚拟工具分析实验测量NO2质量浓度的方法进行评估。本研究在立陶宛卫生研究院有毒化合物检测实验室进行。 | Olga KYSELOVA Grazina SMOLIANSKIENE Danute ADAMONIENE Danguole KAZIUKONIENE Aleksej ROMANOV | 2010 | 生命科学仪器2010，8，5： | 2 |
| 9 | Magnetic properties and hyperfine interactions in the β″ phase of potassium ferrite 显示文摘 | Romanov V P Candela G A Roth R S | 1979 | J Appl Phys1979，50，： | 1 |
| 10 | Scarching for alternative sources of postnatal human mesen:hynJal ,:tcm cells: candidate MSC like cells from umbilical cord 显示文摘 | Romanov YA Svintsilskaya VA Smirnov VN | 2003 | Stem Cells2003，21，1： | 1 |
| 11 | Petroleum migration and trapping mechanism in fine-grained source rock for marion 显示文摘 | Lopatin N V Emets T P Romanov E A | 2003 | Journal of Geochemical Exploration2003，，7879： | 1 |
| 12 | Searching for alter- native sources of postnatal human mesenchymal stem ceils : candidate MSC -like cells from umbilical cord显示文摘 | Romanov YA VA Svintsitskaya and VN Smirnov | 2003 | Stem Cells2003，21，： | 1 |
| 13 | A randomized com- parison of pulmonary vein isolation with versus without concomitant renal artery denervation in patients with refractory symptomatic atrial fibrillation and resistant hypertension显示文摘 | Pokushalov E Romanov A Corbucci G | 2012 | J Am Coil Cardiol2012，60，： | 1 |
| 14 | Cracking of III-Nitride Layers with Strain Gradients显示文摘 | Romanov A E Beltz G E Cantu P | 2006 | Applied Physics Letters2006，89，16： | 1 |
| 15 | Autonomic denezwation added to pulmonary vein isolation for parnxysmal atrial fibrillation: a randomized clinical trial显示文摘 | Katritsis DG Pokushalov E Romanov A | 2013 | J Am Coil Cardiol2013，62，24： | 1 |
| 16 | Production of soluble P-selectin by platelets and endothelial cells显示文摘 | ROMANOV YA LOKTIONOVA SA | 1999 | Biochemistry (Mosc)1999，64，11： | 1 |
| 17 | Searching for ahernativesources of postnatal human mesenchymal stem cells:candidate MSC-like cells from umbilical cord显示文摘 | Romanov YA VA Svintsitskaya and VN Smirnov | 2003 | Stem Cells2003，，21： | 1 |
| 18 | Electrophysiologically identified subpopulation of taste bud cell 显示文摘 | Romanov RA Kolesnikov SS | 2006 | Neurosci Letters2006，395，： | 1 |
| 19 | Egg physical characteristics and hatchability显示文摘 | Narushin V G Romanov M N | 2002 | World''s Poultry Science Journal2002，58，： | 1 |
| 20 | Searching for alternative sources of postnatal human mesenchymal stem cells:Candidate MSC-tike cells from UCB显示文摘 | Romanov YA Svintsitskya VA Smirnov VN | 2003 | Stem cells2003，21，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员