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| 1 | MicroRNA-328 is associated with (non-small) cell lung cancer (NSCLC) brain metastasis and mediates NSCLC migration显示文摘 | Arora S Ranade AR Tran NL Nasser S Sridhar S Korn RL Ross JT Dhruv H Foss KM Sibenaller Z Ryken T Gotway MB Kim S Weiss GJ | 2011 | 中国神经肿瘤杂志2011，9，1： | 30 |
| 2 | Impacts of ozone on the biomass and yield of rice in open top chambers显示文摘The impacts of different O 3 concentration on the biomass and yield of rice were studied by using OTC 1 open top chambers. Experimental treatments included the activated charcoal filtered air (CFA), 50 nl/L (CF50), 100 nl/L (CF100) and 200 nl/L (CF200) concentrations of O 3. The O 3 treatments significantly decreased the total biomass per plant. The elevated O 3 exposure resulted in a more decrease in the root growth than in the shoot growth. Assessments of yield characteristics at the final harvest revealed an O 3 induced decrease in the number of grains per plant, resulting from fewer ears per plant, fewer grains per ear and more unfilled grains per ear. The 1000 grain dry weight and the harvest index (HI) were not changed significantly under 50 nl/L or 100 nl/L O 3 exposure, but reduced by 17.0% and 4.8% by 200nl/L O 3 treatment, respectively. Compared to the CFA treatment, CF50, CF100 and CF200 treatments caused a 8.2%, 26.1%, 49.1% decrease of the grain yield per plant, and a 14 2%, 31 7%, 51 7% decrease of the total biomass per plant, respectively. Linear regression showed that the 7h-daily mean O 3 concentration exposure for 3 months (July September) and AOT40 (cumulative exposure accumulation over threshold 40 nl/L) were well correlated with the relative grain yield. A yield loss of 10% was estimated to be at 46 9 nl/L O 3 for 7h daily mean O 3 concentration exposure or at 12930 nl/(L·h) O 3 for AOT40. | Jin, MB Feng, ZW Zhang, FZ | 2001 | Journal of Environmental Sciences2001，13，2： | 16 |
| 3 | 酒精摄入、心脏生物标志物和心房颤动风险与不良结局显示文摘酒精摄入和新发心房颤动相关性证据不一,尤其是在低剂量下。该研究评估欧洲队列在整个饮酒范围内酒精摄入、生物标志物和新发心房颤动的关系。方法和结果:在一个以社区为基础的汇集队列中,研究者随访107845人,以评估酒精摄入(酒精种类和饮酒方式)与新发心房颤动的关系。研究者收集经典心血管病危险因素和新发心力衰竭的信息,并检测生物标记物氨基末端脑钠肽前体和高敏肌钙蛋白I。 | 陈嘉睿(译) 练桂丽((审校) Csengeri D Sprünker NA Di Castelnuovo A Niiranen T Vishram-Nielsen JK Costanzo S S derberg S Jensen SM Vartiainen E Donati MB Magnussen C Camen S Gianfagna F L chen ML Kee F Kontto J Mathiesen EB Koenig W Stefan B de Gaetano G J rgensen T Kuulasmaa K Zeller T Salomaa V Iacoviello L Schnabel RB | 2021 | 中华高血压杂志2021，29，2： | 9 |
| 4 | 美国军事医学信息学:在战备部署环境下的信息获取显示文摘目的研究在驻防(in garrison)或战备部署条件下美国军医常用的医学信息源。方法向军医发放调查问卷,要求描述军医在驻防或战备部署时最常用的医学信息源。结果多数的军医在驻防时每天利用Internet获取医学信息。驻防时医学资源的利用频率和方式与战备部署期间资源的利用有所不同,最常使用的电子医学信息源是Internet搜索引擎(Google)。外科医生通常使用公开的医学网站(PubMed和MED-LINE)。而军队的初级保健医生(pri mary care physicians)更常使用过滤的二次整合信息源(UptoDate和MDConsult)。年轻的医生比年纪大的医生利用电子资源更频繁。结论了解军医使用何种医学信息源进行检索解决临床问题有助于指导医学信息源的分配,尤其是有助于为战备部署时进行战场救护的军医提供医学信息资源的分配指导。 | Stephens MB Von Thunt AM 郝丽云 徐世侠 | 2009 | 海军总医院学报2009，22，4： | 7 |
| 5 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 6 | Molecular biology of Barrett's esophagus and esophageal cancer:role of p53显示文摘MolecularbiologyofBaret′sesophagusandesophagealcancer:roleofp53AlanG.Casson,MBChBMScFRCSCFACSSubjectheadingsesophagealneoplas... | Alan G. Casson, MB ChB MSc FRCSC FACS | 1998 | World Journal of Gastroenterology1998，4，4： | 6 |
| 7 | 新型低密度脂蛋白胆固醇评估对全球血脂异常指南中次级靶标非高密度脂蛋白胆固醇和载脂蛋白B应用的影响显示文摘血脂异常指南通常推荐非高密度脂蛋白胆固醇(non-high-density lipoprotein-cholesterol,non-HDL-C)和载脂蛋白B(apolipoprotein B,apoB)作为主要靶点低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)的次要靶点。 | Sathiyakumar V Park J Quispe R Elshazly MB Michos ED Banach M Toth PP Whelton SP Blumenthal RS Jones SR Martin SS 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，4： | 4 |
| 8 | 经皮神经电刺激治疗女性纤维肌痛疗效取决于最初30分钟显示文摘前期研究表明,经皮神经电刺激(transcutaneous electrical nerve stimulation, TENS)治疗1个月可缓解纤维肌痛(fibromyalgia, FM)女性运动诱发的疼痛和疲劳。该研究再次使用前期TENS治疗FM的研究数据,进行应答者分析,以明确TENS治疗缓解疼痛和疲劳的预测因素,并使用受试者工作特征曲线验证预测模型,确定治疗所需数量(number needed to treat, NNT)和危害所需数量(number needed to harm, NNH)。FM女性病人被随机分配到TENS治疗组、TENS假治疗组和未使用TENS组。随机分组后,受试者接受治疗/假治疗1个月,接着TENS假治疗组和未使用TENS组再接受TENS治疗1个月。预测模型使用TENS治疗组(n=103)数据构建,并用TENS假治疗组和未使用TENS组(n=155)在后继TENS治疗1个月后的数据进行验证。使用逻辑回归模型筛选受试者特征、疼痛和疲劳对TENS治疗的初始反应、睡眠和心理等,以确定其与疼痛或疲劳变化之间的关系。疼痛包括TENS治疗后疼痛初始反应和病人疼痛广泛指数(AUC为0.80;95%置信区间:0.73-0.87)。疲劳改善的预测因素包括对TENS治疗的初始反应、婚姻状况和睡眠障碍(AUC为0.67;95%置信区间:0.58-0.75)。疼痛和疲劳的NNT为3.3-5.3,NNH为20-100。若最初30分钟TENS治疗有效则该FM女性病人长期使用TENS有效,而且该模型得到了后继的临床验证。NNT和NNH的结果表明TENS对管理FM女性病人的疼痛和疲劳安全有效。 | 梅相阳(译) 冯智英(校) Vance CGT Zimmerman MB Dailey DL | 2021 | 中国疼痛医学杂志2021，27，11： | 4 |
| 9 | Effects of combination lipid therapy in type 2 diabetes mellitus显示文摘 | Ginsberg HN Elam MB Lovato LC | | New England Journal of Medicine0，，： | 4 |
| 10 | 俄罗斯职业教育及职业培训经费筹集模式构想显示文摘 | 尼.,MB 平凡 | 2000 | 世界职业技术教育2000，，1： | 3 |
| 11 | A Computational Model for Two-Stage 4K-Pulse Tube Cooler: Part Ⅱ. Predicted Results显示文摘The internal physical processes and performance of a two-stage pulse tube cooler operating at 4 K-temperature region are numerically analyzed by a new mixed Eulerian-Lagrangian computational model. The detailed time-variations of gas temperature, pressure, mass flow rate, enthalpy flow in a cycle, in the first and the second-stage regenerators are presented in the paper. The behavior of the various gas elements, which enter the pulse tube from its cold end has been revealed and discussed. More attention is paid to the effects of different regenerative materials on the performance of the 4 K two-stage pulse tube cooler. | Y.L.Ju (Cryogenic Laboratory, Chinese Academy of Sciences, P. 0. Box 2711, Beijing 100080, P.R. China) A. T. A. M. de Waele (Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, NL-5600 MB Eindhoven, the Netherlands) | 2002 | Journal of Thermal Science2002，11，1： | 3 |
| 12 | Epidemiology of Parkinson’s disease显示文摘 | Lonneke ML de Lau Monique MB Breteler | 2006 | Lancet Neurology2006，，6： | 3 |
| 13 | Lipotoxicity in the liver显示文摘Obesity due to excessive food intake and the lack of physical activity is becoming one of the most serious public health problems of the 21stcentury. With the increasing prevalence of obesity, non-alcoholic fatty liver disease is also emerging as a pandemic. While previously this pathophysiological condition was mainly attributed to triglyceride accumulation in hepatocytes,recent data show that the development of oxidative stress, lipid peroxidation, cell death, inflammation and fibrosis are mostly due to accumulation of fatty acids,and the altered composition of membrane phospholipids. In fact, triglyceride accumulation might play a protective role, and the higher toxicity of saturated or trans fatty acids seems to be the consequence of a blockade in triglyceride synthesis. Increased membrane saturation can profoundly disturb cellular homeostasis by impairing the function of membrane receptors,channels and transporters. However, it also inducesendoplasmic reticulum stress via novel sensing mechanisms of the organelle's stress receptors. The triggered signaling pathways in turn largely contribute to the development of insulin resistance and apoptosis. These findings have substantiated the lipotoxic liver injury hypothesis for the pathomechanism of hepatosteatosis.This minireview focuses on the metabolic and redox aspects of lipotoxicity and lipoapoptosis, with special regards on the involvement of endoplasmic reticulum stress responses. | Veronika Zámbó Laura Simon-Szabó Péter Szelényi va Kereszturi Gábor Bánhegyi Miklós Csala | 2013 | World Journal of Hepatology2013，5，10： | 3 |
| 14 | 2型糖尿病高血糖的起始和调整治疗共识——美国糖尿病学会和欧洲糖尿病研究协会联合共识显示文摘专家点评:在2005年欧洲糖尿病研究协会(EASD)年会上,国际糖尿病联盟(IDF)颁布了全球首个2型糖尿病治疗指南,我国也发布了自己的指南,然而无论哪个指南,其中主要部分是参考欧美主持的全球多中心临床研究结果。糖尿病药物研究近些年进展迅速,即使在指南的范畴内,仍然有很多选择,令临床医生难以取舍。本文编译介绍了现阶段各种用于2型糖尿病治疗的药物,结合临床研究结果,突出其各自临床应用的优缺点;同时,在药物联合使用和进阶治疗方面,介绍了具体的实施方案和流程,为临床达标治疗的用药选择提供了实用的参考。 | Nathan DM Buse JB Davidson MB 华雪蔚 | 2007 | 世界临床药物2007，28，6： | 3 |
| 15 | On seeing things显示文摘 | Clowes MB | 1971 | Artificial Intelligence1971，2，1： | 3 |
| 16 | 成矿学的过去、现在和将来显示文摘成矿学起源于大约100年前,在地学领域中已赢得了特定的地位。笔者将成矿学细分为经验成矿学、矿床成因论和应用成矿学,系统地论述了三者的关系及其发展简史,并展望了现代电子技术对成矿学研究方法的重大影响。对成矿学研究的现状和困难也做了一些分析。本文强调矿床实际资料的积累、加工、储存(信息库)和全球范围的交流。着重指出:细致描述和用图示记录目前开采矿床的重要性;用全部学识记录和处理岩石和(或)矿石样品的重要性以及利用多种文字的地区性文献(如野外报告或地质图)提供全球性资料的重要性。 | Peter Laznicka(University of Manitoba,Winnipeg,MB,Canada) | 1994 | 地学前缘1994，1，3： | 3 |
| 17 | Analysis and sequence of the speB geneencoding agmatine ureohydrolase, a putrescine biosynthetic enzyme inEscherichia coli 显示文摘 | Szumanski MB Boyle SM | 1990 | J Bacteriol1990，172，2： | 2 |
| 18 | Effect of Carvedilol on survival in severe chronic heart failure显示文摘 | Packer M Coats AJS Fowler MB | 2001 | N Engl J Med2001，344，22： | 2 |
| 19 | NIDDM as a disease of the innate immune system association of acute-phase reactants and interleukin-6 with metabolic syndrome-X显示文摘 | Dickup JC Mattock MB Chusney GD | 1997 | Diabetologia1997，40，11： | 2 |
| 20 | Ultrasound of the Breast 显示文摘 | Kossoff MB | 2000 | World J Surg2000，24，： | 2 |
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