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| 1 | Hepatitis C virus molecular evolution:Transmission,disease progression and antiviral therapy显示文摘Hepatitis C virus(HCV)infection represents an important public health problem worldwide.Reduction of HCV morbidity and mortality is a current challenge owned to several viral and host factors.Virus molecular evolution plays an important role in HCV transmission,disease progression and therapy outcome.The high degree of genetic heterogeneity characteristic of HCV is a key element for the rapid adaptation of the intrahost viral population to different selection pressures(e.g.,host immune responses and antiviral therapy).HCV molecular evolution is shaped by different mechanisms including a high mutation rate,genetic bottlenecks,genetic drift,recombination,temporal variations and compartmentalization.These evolutionary processes constantly rearrange the composition of the HCV intrahost population in a staging manner.Remarkable advances in the understanding of the molecular mechanism controlling HCV replication have facilitated the development of a plethora of direct-acting antiviral agents against HCV.As a result,superior sustained viral responses have been attained.The rapidly evolving field of anti-HCV therapy is expected to broad its landscape even further with newer,more potent antivirals,bringing us one step closer to the interferon-free era. | Maria Victoria Preciado Pamela Valva Alejandro Escobar-Gutierrez Paula Rahal Karina Ruiz-Tovar Lilian Yamasaki Carlos Vazquez-Chacon Armando Martinez-Guarneros Juan Carlos Carpio-Pedroza Salvador Fonseca-Coronado Mayra Cruz-Rivera | 2014 | World Journal of Gastroenterology2014，20，43： | 6 |
| 2 | Postpartum depression:A systematic review of the genetics involved显示文摘Postpartum depression is one of the most prevalent psychopathologies. Its prevalence is estimated to be between 10% and 15%. Despite its multifactorial etiology, it is known that genetics play an important role in the genesis of this disorder. This paper reviews epidemiological evidence supporting the role of genetics in postpartum depression(PPD). The main objectives of this review are to determine which genes and polymorphisms are associated with PPD and discuss how this association may occur. In addition, this paper explores whether these genes are somehow related to or even the same as those linked to Major Depression(MD). To identify gaps in the current knowledge that require investigation, a systematic review was conducted in the electronic databases Pub Med, LILACS and Sci ELO using the index terms 'postpartum depression' and 'genetics'. Literature searches for articles in peerreviewed journals were made until April 2014. PPD was indexed 56 times with genetics. The inclusion criteria were articles in Portuguese, Spanish or English that were available by institutional means or sent by authors upon request; this search resulted in 20 papers. Genes and polymorphisms traditionally related to MD, which are those involved in the serotonin, catecholamine, brain-derived neurotrophic factor and tryptophan metabolism, have been the most studied, and some have been related to PPD. The results are conflicting and some depend on epigenetics, which makes the data incipient. Further studies are required to determine the genes that are involved in PPD and establish the nature of the relationship between these genes and PPD. | Tiago Castro e Couto Mayra Yara Martins Brancaglion António Alvim-Soares Lafaiete Moreira Frederico Duarte Garcia Rodrigo Nicolato Humberto Corrêa Regina Amélia Lopes P Aguiar Henrique Vitor Leite | 2015 | World Journal of Psychiatry2015，5，1： | 5 |
| 3 | Nutritional evaluation of integral cassava root silages for growing pigs显示文摘The experiment aimed at determining the nutritional value of integral cassava root silages with yogurt as inoculant or wastewater(manipueira) by liquid addition ensiling process. Eighteen crossbred piglets(Large White x Landrace), castrated males with an initial average weight of 50 kg were allocated in metabolism cages throughout 11-day trial duration(6 days for animal's adaptation to the cages and to the experimental diets, and 5 days of urine and faeces collection). The experimental design was a randomized block arrangement with 3 treatments and 6 replicates: basal diet(100%); mixture composed of75% basal diet and 25% integral cassava root silage with yogurt as inoculant; a mixture composed of 75%of basal diet and 25% integral cassava root silage with wastewater. The silages with wastewater and yogurt presented the following values of apparent digestibility of dry matter 89.96% and 90.01%,apparent digestibility of crude protein of 60.67% and 66.43%, apparent digestibility of gross energy of90.43% and 91.48%, gross energy metabolizability coefficients of 87.88% and 88.93%, digestible energy values of 3,705 and 3,783 kcal/kg on a dry matter(DM) basis, and metabolizable energy values of 3,600 and 3,676 kcal/kg DM, respectively. The results have demonstrated that integral cassava root silages with wastewater or yogurt have a high nutritional value and can be used as an alternative energy source in growing pig's diets. | Diego D.Araújo Alessandro B.Amorim Mayra A.D.Saleh Felipe Curcelli Pedro L.Perdigón Silvio J.Bicudo Dirlei A.Berto | 2016 | Animal Nutrition2016，，3： | 5 |
| 4 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 5 | First Report of a Closterovirus-Like Particle Associated with Pineapple Plants显示文摘 | Eduviges G B Mayra Cintra Justo Gonzalez | 1998 | Plant Disease1998，82，2： | 1 |
| 6 | Analysis of Minerals and Rocks by Laser-Induced Breakdown Spectroscopy显示文摘 | DiegoM. Díaz Pace NorbertoA. Gabriele Mayra Garcimu?o CristianA. D’Angelo Graciela Bertuccelli Daniela Bertuccelli | 2011 | Spectroscopy Letters2011，，6： | 1 |
| 7 | Development and characterization of composite edible films based on whey protein isolate and mesquite gum显示文摘 | Javier O Mayra F V Ruth P I | 2009 | Journal of Food Engineering2009，92，1： | 1 |
| 8 | Living in metamorphosis:proactive computing in the home environment显示文摘 | Vanhala J Mayra F Koskinen I | 2005 | Interactions of ACM2005，，4： | 1 |
| 9 | The effectiveness of R&D subsidies 显示文摘 | Mayra R Sandonis J | 2012 | Economics of Innovation& New Technology2012，21，8： | 1 |
| 10 | Telomere length and risk of incident cancer and cancer mortality显示文摘 | Willeit P Willeit J MayrA | 2010 | JAMA2010，304，1： | 1 |
| 11 | Fibrinogen Stabilizes Placental Maternal Attachment During Embryonic Development in the Mouse显示文摘 | Mayra J Sandoval-Cooper | 2002 | American Journal of Pathology2002，160，3： | 1 |
| 12 | Fibrinogen Stabilizes Placental Maternal Attachment During Embryonic Development in the Mouse显示文摘 | Takayuki lwaki Mayra J Sandoval-Cooper | 2008 | American Journal of Pathology2008，160，3： | 1 |
| 13 | Production of propionate by fed-batch fermentation of Propionibacterium acidipropionici using mixed feed of lactate and glucose显示文摘 | ROBERTO MARTINEZ-CAMPOS MAYRA DE LA TORRE | 2002 | Biotechnology Letters2002，24，： | 1 |
| 14 | Breast Microcalcifications: Multivariate Analysis of Radiologicand Clinical Factors for Carcinoma显示文摘 | Eric Fondrinier Gérard Lorimier Véronique Guerin-Boblet Andrée-Fran?oise Bertrand Claude Mayras Nicolette Dauver | 2002 | World Journal of Surgery2002，，3： | 1 |
| 15 | The subjective components of happiness and their attainment:a cross - cultural comparison between Italy and Cuba显示文摘 | Dario G Mayra M Lgor $ | 2006 | Soc Sci Inform2006，45，4： | 1 |
| 16 | Culture medium improvement for Isaria fumosorosea submerged conidia production显示文摘 | Ali Asaff Francisco Escobar Mayra de la Torre | | 0，，： | 1 |
| 17 | Agglomeration of Ni-rich hydroxide crystals in Taylor vortex flow显示文摘 | Dien Khuong Thai Queme-Pena Mayra Woo-Sik Kim | 2015 | Powder Technology2015，274，： | 1 |
| 18 | Investigation of the effects of salinity and dietary protein level on growth and survival of Pacific white shrimp, Litopenaeus vannamei 显示文摘 | Martin P V Mayra L G Fernando J B | 2007 | J World Aquac Soc2007，38，4： | 1 |
| 19 | Drug induced cholestasis显示文摘 | Manmeet S Padda MD Mayra SMD | 2011 | Hepatology2011，53，4： | 1 |
| 20 | Developing the Ethnic Identity Scale Using Eriksonian and Social Identity Perspectives显示文摘 | Adriana J. Umana-Taylor Ani Yazedjian Mayra Bamaca-Gomez | 2004 | Identity2004，，1： | 1 |
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