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| 1 | Chronic hepatitis C virus infection:Serum biomarkers inpredicting liver damage显示文摘Currently, a major clinical challenge in the management of the increasing number of hepatitis C virus(HCV) infected patients is determining the best means for evaluating liver impairment. Prognosis and treatment of chronic hepatitis C(CHC) are partly dependent on the assessment of histological activity, namely cell necrosis and inflammation, and the degree of liver fibrosis. These parameters can be provided by liver biopsy; however, in addition to the risks related to an invasive procedure, liver biopsy has been associated with sampling error mostly due to suboptimal biopsy size. To avoid these pitfalls, several markers have been proposed as non-invasive alternatives for the diagnosis of liver damage. Distinct approaches among the currently available non-invasive methods are(1) the physical ones based on imaging techniques; and(2) the biological ones based on serum biomarkers. In this review, we discuss these approaches with special focus on currently available non-invasive serum markers. We will discuss:(1) class?Ⅰ?serum biomarkers individually and as combined panels, particularly those that mirror the metabolism of liver extracellular matrix turnover and/or fibrogenic cell changes;(2) class Ⅱ biomarkers that are indirect serum markers and are based on the evaluation of common functional alterations in the liver; and(3) biomarkers of liver cell death, since hepatocyte apoptosis plays a significant role in the pathogenesis of HCV infection. We highlight in this review the evidence behind the use of these markers and assess the diagnostic accuracy as well as advantages, limitations, and application in clinical practice of each test for predicting liver damage in CHC. | Pamela Valva Daniela A Ríos Elena De Matteo Maria V Preciado | 2016 | World Journal of Gastroenterology2016，22，4： | 2 |
| 2 | Laparoscopic management of ovar- ian cysts in newborns 显示文摘 | Esposito C Garipoli V Di Matteo G | 1998 | Surg Endosc1998，12，9： | 1 |
| 3 | Action fluency in Parkinson's disease:a follow-up study显示文摘 | MATTEO S CHIARA V | 2006 | Movement Disorders2006，21，4： | 1 |
| 4 | Laparoscopic management of ovarian cysts in newborns 显示文摘 | Esposito C Garipoli V Di Matteo G | 1998 | Surg Endosc1998，12，9： | 1 |
| 5 | Serotonin modula- tion of the basal ganglia circuitry: therapeutic implication for Parkinson's disease and other motor disorders 显示文摘 | Di Matteo V Pierucci M Esposito E | 2008 | Prog Brain Res2008，172，： | 1 |
| 6 | Biochemical evidence that tire atypical antipsychotic drags dozapine and rispenlone block 5-HT (2C) receptors in vivo显示文摘 | Di Matteo V Cacchio M Di Giulio C | 2002 | Phannacol Biochem Behav2002，71，4： | 1 |
| 7 | Laparoscopic management of ovarian cysts in newborns显示文摘 | Esposito C Garipoli V Matteo GD | 1998 | Surg Endosc1998，12，9： | 1 |
| 8 | Phthalate esters in freshwaters as markers of contamination sources-a site study in Italy显示文摘 | Matteo V | 1997 | Environment International1997，23，： | 1 |
| 9 | Intake of tomato-en- riched diet protects from 6-hydroxydopamine-induced degeneration of rat nigral dopaminergic neurons 显示文摘 | di Matteo V Pierucci M Di Giovanni G | 2009 | J Neural Transmission2009，73，： | 1 |
| 10 | Epstein-Barr virus in breast carcinoma in Argentina显示文摘 | Preciado M V Chabay P A De Matteo E N | 2005 | Arch Pathol Lab Med2005，129，3： | 1 |
| 11 | Insight into B cell development and differentiation显示文摘 | Moschese V Orlandi P Di Matteo G | 2004 | Acta Paediatr Suppl2004，93，445： | 1 |
| 12 | Prognostic value of the metabolic syndrome in essential hypertension显示文摘 | Giuseppe S Matteo P Gaetano V | 2004 | J Am Coll Cardiol2004，43，10： | 1 |
| 13 | Evolution of compressive strains in retained austenite during sub-zero Celsius martensite formation and tempering 显示文摘 | Matteo V Karen P Marcel A J S | 2014 | Acta Materialia2014，65，： | 1 |
| 14 | Intrinsic and environmental effects in the structure and magnetic properties of organic molecular magnets:bis(imino)nitroxide 显示文摘 | Barone V Bencini A Matteo A D | 1997 | J Am Chem Soc1997，119，10： | 1 |
| 15 | Effect of acute administration of hypericum perforatum-CO2 extract on dopamine and serotonin release in the rat central nervous system显示文摘 | Di Giovanni G | 2000 | Pharmcopsychiatry2000，，1： | 1 |
| 16 | Effect of acute administration of hypericum perforatum-CO2 extract on dopamine and serotonin release in the rat central nervous system显示文摘 | Di Matteo V Di Giovanni G Di Mascio M | 2000 | Pharmacopsychiatry2000，33，： | 1 |
| 17 | Aerobic submerged fermen- tation by acetic acid bacteria for vinegar production: Process and biotechnological aspects 显示文摘 | Maria G Elena V Matteo C | 2014 | Process Biochemistry2014，49，10： | 1 |
| 18 | Opportunities and developments in fluoropolymeric coatingsr显示文摘 | MATTEO V | 2000 | Prog Org Coat2000，40，14： | 1 |
| 19 | Prognostic value of the metabolic syn- drome in essential hypertension显示文摘 | Giuseppe S Matteo P Gaetano V | 2004 | J Am Coil Cardio12004，43，： | 1 |
| 20 | Intake of tomato-enriched diet protects from 6 - hydroxydopamine - induceddegeneration of rat nigral dopaminergic neurons 显示文摘 | Matteo V Pierucci M Di Giovanni G | 2009 | Journal ofNeural Transmission2009，73，： | 1 |
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