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| 1 | Balloon aortic valvuloplasty as a bridge-to-decision in high risk patients with aortic stenosis: a new paradigm for the heart team decision making显示文摘BackgroundWhilst 有严重大动脉的狭窄的病人的多数能直接针对外科的大动脉的阀门代替(AVR ) 或 transcatheter 大动脉的阀门培植(TAVI ) ,在一些例子,另外的信息可以被需要完成诊断体育锻练。我们评估了汽球的角色大动脉的 valvuloplasty (BAV ) 作为在选择高风险的 patients.MethodsBetween 的 bridge-to-decision (BTD ) 2007 和 2012,在我们的机构的心队在 202 个病人要求了 BTD BAV。很低的左室的喷射部分,僧帽形的流回等级 ≥3,这些因素的脆弱,血液动力学的不稳定性,严肃的 comorbidity,或联合是为这策略的主要司机。我们评估了 BAV 怎么在整个耐心的组并且在为心脏的起作用的风险评估(EuroSCORE ) 的逻辑欧洲系统是的各特定的 subgroup.ResultsMean 影响了最后的治疗策略 23.5%±15.3% ,年龄 81 ±7 年。在里面医院死亡是 4.5% ,脑血管的事故 1% 并且全面脉管的复杂并发症 4%(0.5% 专业;3.5% 未成年者) 。熬过并且收到第二心队评估的有 BTD BAV 的 193 个病人, 72.6% 最后被认为为权威的治疗合格(25.4% 为 AVR;47.2% 为 TAVI ) :有左室的喷射部分恢复的 96.7% 病人;有僧帽形的流回减小的 70.5% 病人;在临床的血液动力学的不稳定性经历了 BAV 的 75.7% 病人;69.2% 脆弱的病人和不能是权威的 transcatheter 或外科的治疗的立即的候选人的介绍了大动脉的 valvuloplasty 能与严重大动脉的狭窄在高风险的病人被看作 bridge-to-decision 的严肃的 comorbidities.ConclusionsBalloon 的 68% 病人。 | Francesco Saia Carolina Moretti Gianni Dall'Ara Cristina Ciuca Nevio Taglieri Alessandra Berardini Pamela Gallo Marina Cannizzo Matteo Chiarabelli Niccolo Ramponi Linda Taffani Maria Letizia Bacchi-Reggiani Cinzia Marrozzini Claudio Rapezzi Antonio Marzocchi | 2016 | Journal of Geriatric Cardiology2016，13，6： | 0 |
| 2 | Assessing the response of human primary macrophages to defined fibrous architectures fabricated by melt electrowriting显示文摘The dual role of macrophages in the healing process depends on macrophage ability to polarize into phenotypes that can propagate inflammation or exert anti-inflammatory and tissue-remodeling functions.Controlling scaf-fold geometry has been proposed as a strategy to influence macrophage behavior and favor the positive host response to implants.Here,we fabricated Polycaprolactone(PCL)scaffolds by Melt Electrowriting(MEW)to investigate the ability of scaffold architecture to modulate macrophage polarization.Primary human macrophages unpolarized(M0)or polarized into M1,M2a,and M2c phenotypes were cultured on PCL films and MEW scaffolds with pore geometries(square,triangle,and rhombus grid)characterized by different angles.M0,M2a,and M2c macrophages wrapped along the fibers,while M1 macrophages formed clusters with rounded cells.Cell bridges were formed only for angles up to 90◦.No relevant differences were found among PCL films and 3D scaffolds in terms of surface markers.CD206 and CD163 were highly expressed by M2a and M2c macrophages,with M2a macrophages presenting also high levels of CD86.M1 macrophages expressed moderate levels of all markers.The rhombus architecture promoted an increased release by M2a macrophages of IL10,IL13,and sCD163 compared to PCL films.The proangiogenic factor IL18 was also upregulated by the rhombus configuration in M0 and M2a macrophages compared to PCL films.The interesting findings obtained for the rhombus architecture represent a starting point for the design of scaffolds able to modulate macrophage phenotype,prompting investigations addressed to verify their ability to facilitate the healing process in vivo. | Carlotta Mondadori Amit Chandrakar Silvia Lopa Paul Wieringa Giuseppe Tal`o Silvia Perego Giovanni Lombardi Alessandra Colombini Matteo Moretti Lorenzo Moroni | 2023 | Bioactive Materials2023，，3： | 0 |
| 3 | Generation of quantum-certified random numbers using on-chip path-entangled single photons from an LED显示文摘Single-photon entanglement is a peculiar type of entanglement in which two or more degrees of freedom of a single photon are correlated quantum-mechanically. Here, we demonstrate a photonic integrated chip able to generate and manipulate single-photon path-entangled states, using a commercial red LED as light source.A Bell test, in the Clauser, Horne, Shimony, and Holt(CHSH) form, is performed to confirm the presence of entanglement, resulting in a maximum value of the CHSH correlation parameter equal to 2.605 ± 0.004.This allows us to use it as an integrated semi-device independent quantum random number generator able to produce certified random numbers. The certification scheme is based on a Bell’s inequality violation and on a partial characterization of the experimental setup, without the need of introducing any further assumptions either on the input state or on the particular form of the measurement observables. In the end a min-entropy of 33% is demonstrated. | NICOLÒ LEONE STEFANO AZZINI SONIA MAZZUCCHI VALTER MORETTI MATTEO SANNA MASSIMO BORGHI GIOELE PICCOLI MARTINO BERNARD MHER GHULINYAN LORENZO PAVESI | 2023 | Photonics Research2023，11，9： | 0 |
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