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| 1 | Intermodal four-wave mixing in silicon waveguides显示文摘In this work, we report the modeling and the experimental demonstration of intermodal spontaneous as well as stimulated four-wave mixing(FWM) in silicon waveguides. In intermodal FWM, the phase-matching condition is achieved by exploiting the different dispersion profiles of the optical modes in a multimode waveguide. Since both the energy and the wave vectors have to be conserved in the FWM process, this leads to a wide tunability of the generated photon wavelength, allowing us to achieve a large spectral conversion. We measured several waveguides that differ by their widths and demonstrate large signal generation spanning from the pump wavelength(1550 nm) down to 1202 nm. A suited setup evidences that the different waves propagated indeed on different order modes, which supports the modeling. Despite observing a reduced efficiency with respect to intramodal FWM due to the decreased modal overlap, we were able to show a maximum spectral distance between the signal and idler of 979.6 nm with a 1550 nm pump. Our measurements suggest the intermodal FWM is a viable means for large wavelength conversion and heralded photon sources. | STEFANO SIGNORINI MATTIA MANCINELLI MASSIMO BORGHI MARTINO BERNARD MHER GHULINYAN GEORG PUCKER LORENZO PAVESI | 2018 | Photonics Research2018，6，8： | 1 |
| 2 | Complete crossing of Fano resonances in an optical microcavity via nonlinear tuning显示文摘We report on the modeling, simulation, and experimental demonstration of complete mode crossings of Fano resonances within chip-integrated microresonators. The continuous reshaping of resonant line shapes is achieved via nonlinear thermo-optical tuning when the cavity-coupled optical pump is partially absorbed by the material.The locally generated heat then produces a thermal field, which influences the spatially overlapping optical modes, allowing us to alter the relative spectral separation of resonances. Furthermore, we exploit such tunability to continuously probe the coupling between different families of quasi-degenerate modes that exhibit asymmetric Fano interactions. As a particular case, we demonstrate a complete disappearance of one of the modal features in the transmission spectrum as predicted by Fano [Phys. Rev. 124, 1866(1961)]. The phenomenon is modeled as a third-order nonlinearity with a spatial distribution that depends on the stored optical field and thermal diffusion within the resonator. The performed nonlinear numerical simulations are in excellent agreement with the experimental results, which confirm the validity of the developed theory. | MARTINO BERNARD FERNANDO RAMIRO MANZANO LORENZO PAVESI GEORG PUCKER IACOPO CARUSOTTO MHER GHULINYAN | 2017 | Photonics Research2017，5，3： | 1 |
| 3 | Subclinical proximal tubulopathy in hepatitis B:The roles of nucleot(s)ide analogue treatment and the hepatitis B virus显示文摘BACKGROUND The recommended monitoring tools for evaluating nucleot(s)ide analogue renal toxicity,such as estimated glomerular filtration rate(eGFR)and phosphatemia,are late markers of proximal tubulopathy.Multiple early markers are available,but no consensus exists on their use.AIM To determine the 24 mo prevalence of subclinical proximal tubulopathy(SPT),as defined with early biomarkers,in treated vs untreated hepatitis B virus(HBV)-monoinfected patients.METHODS A prospective,non-randomized,multicenter study of HBV-monoinfected patients with a low number of renal comorbidities was conducted.The patients were separated into three groups:Naïve,starting entecavir(ETV)treatment,or starting tenofovir disoproxil(TDF)treatment.Data on the early markers of SPT,the eGFR and phosphatemia,were collected quarterly.SPT was defined as a maximal tubular reabsorption of phosphate/eGFR below 0.8 mmoL/L and/or uric acid fractional excretion above 10%.The prevalence and cumulative incidence of SPT at month 24(M24)were calculated.Quantitative data were analyzed using analyses of variance or Kruskal-Wallis tests,whereas chi-squared or Fisher’s exact tests were used to analyze qualitative data.Multivariate analyses were used to adjust for any potential confounding factors.RESULTS Of the 196 patients analyzed,138(84 naïve,28 starting ETV,and 26 starting TDF)had no SPT at inclusion.At M24,the prevalence of SPT was not statistically different between naïve and either treated group(21.1%vs 30.7%,P<0.42 and 50.0%vs 30.7%,P=0.32 for ETV and TDF,respectively);no patient had an eGFR lower than 50 mL/min/1.73 m²or phosphatemia less than 0.48 mmoL/L.In the multivariate analysis,no explanatory variables were identified after adjustment.The cumulative incidence of SPT over 24 mo(25.5%,13.3%,and 52.9%in the naïve,ETV,and TDF groups,respectively)tended to be higher in the TDF group vs the naïve group(hazard ratio:2.283,P=0.05).SPT-free survival at M24 was 57.6%,68.8%,and 23.5%for the naïve,ETV,and TDF groups,respectively.The median survival time without SPT,evaluated only in the TDF group,was 5.9 mo.CONCLUSION The prevalence and incidence of SPT was higher in TDF-treated patients compared to naïve patients.SPT in the naïve population suggests that HBV can induce renal tubular toxicity. | Anais Brayette Marie Essig Paul Carrier Marilyne Debette-Gratien Anais Labrunie Sophie Alain Marianne Maynard Nathalie Ganne-Carrie Eric Nguyen-Khac Pauline Pinet Victor De Ledinghen Christophe Renou Philippe Mathurin Claire Vanlemmens Vincent Di Martino Anne Gervais Juliette Foucher Fouchard-Hubert Isabelle Julien Vergniol Isabelle Hourmand-Ollivier Daniel Cohen Xavier Duval Thierry Poynard Marc Bardou Armand Abergel Manh-Thong Dao Thierry Thevenot Jean-Baptiste Hiriart Valerie Canva Guillaume Lassailly Christine Aurières Nathalie Boyer Dominique Thabut Pierre-Henri Bernard Matthieu Schnee Dominique Larrey Bertrand Hanslik Severine Hommel Jeremie Jacques Veronique Loustaud-Ratti | 2020 | World Journal of Hepatology2020，12，12： | 0 |
| 4 | Generation of quantum-certified random numbers using on-chip path-entangled single photons from an LED显示文摘Single-photon entanglement is a peculiar type of entanglement in which two or more degrees of freedom of a single photon are correlated quantum-mechanically. Here, we demonstrate a photonic integrated chip able to generate and manipulate single-photon path-entangled states, using a commercial red LED as light source.A Bell test, in the Clauser, Horne, Shimony, and Holt(CHSH) form, is performed to confirm the presence of entanglement, resulting in a maximum value of the CHSH correlation parameter equal to 2.605 ± 0.004.This allows us to use it as an integrated semi-device independent quantum random number generator able to produce certified random numbers. The certification scheme is based on a Bell’s inequality violation and on a partial characterization of the experimental setup, without the need of introducing any further assumptions either on the input state or on the particular form of the measurement observables. In the end a min-entropy of 33% is demonstrated. | NICOLÒ LEONE STEFANO AZZINI SONIA MAZZUCCHI VALTER MORETTI MATTEO SANNA MASSIMO BORGHI GIOELE PICCOLI MARTINO BERNARD MHER GHULINYAN LORENZO PAVESI | 2023 | Photonics Research2023，11，9： | 0 |
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