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11篇 您的检索式：作者名="Mathews DA"

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		题名	作者	年代	出处	被引量
	1	Characterization of cytotoxic compound from mangrove derived fungi Irpex hydnoides VB4显示文摘Objective:To investigate the cytotoxic activity of endophytic fungi isolated from mangrove fungi.Methods:In the present study the DNA was isolated and the ITS region of 5.8s rRNA was amplified using specific primers ITS 1 and ITS4 and sequence was determined using automated sequencers.Blast search sequence similarity was found against the existing non redundant nucleotide sequence database thus,identified as Aspergilus flavus,Hyporcaea lixii,Aspergillus niger,Eutorium amstelodami,Irpex hydnoides and Neurospora crassa.Among the seven isolates, one fungi Irpex hydnoides was selected for further studies.The fungi were grown in sabouraud broth for five days and filtrate were separated and subjected to ethyl acetate for further studies. Results:Nearly half(49.25%) of the extracts showed activity(IC_(50) of 125 μ g/mL).These values were within the cutoff point of the National Cancer Institute criteria for cytotoxicity(IC_(50)<20 μ g/mL) in the screening of crude plant extracts.The GC MS analysis revealed that the active principals might be Tetradecane(6.26%) with the RT 8.606.Conclusions:It is clear from the present study that mangrove fungi with bioactive metabolites can be expected to provide high quality biological material for high throughout biochemical,anti cancer screening programmes.The results help us conclude that me potential of using metabolic engineering and post genomic approaches to isolate more novel bioactive compounds and to make their possible commercial application is not far off.	B Valentin Bhimba DA Agnel Defora Franco Geena Mary Jose Jibi Merin Mathew Elsa Lycias Joel	2011	Asian Pacific Journal of Tropical Biomedicine2011，1，3：	3
	2	Primary leptomeningeal plasmablastic lymphoma显示文摘	Mathews MS1 Bota DA Kim RC	2011	J Neurooncol2011，104，3：	1
	3	Percutaneous stereotactic differential radiofrequency thermal rhizotomy for the treatment of trigeminal neuralgia显示文摘	Scrivani SJ Keith DA Mathews ES	1999	J Oral Maxillofac Surg1999，57，：	1
	4	Percutaneous stereotactic differential radiofrequency thermal rhizotomy for the treatment of trigeminal neuralgia显示文摘	Scrivani SJ Keith DA Mathews ES	1999	J Oral Maxillofac Surg1999，57，：	1
	5	Percutaneous stereotactic differential radiofreqency thermal rhizotomy for the treatment of trigeminal neuralgia显示文摘	Keith DA Mathews ES	1999	J Oral Maxillofac Surg1999，57，：	1
	6	Role-reversal exercise with Deaf Strong Hospital to teach communication compe- tency and cultural awareness显示文摘	Mathews JL Parkhilt AL Schlehofer DA	2011	Am J Pharm Educ2011，75，3：	1
	7	Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes显示文摘	Mathews DA Dragovich PS Webber SA	1999	Proc Natl Acad Sci USA1999，96，11：	1
	8	Renal cell carcinoma sub-typing by histopathology and fluorescence in situ hybridization on a needle-biopsy specimen显示文摘	Barocas DA Mathew S DelPizzo JJ	2007	BJU Int2007，99，2：	1
	9	Evidence for attention to threatening stimuli in depression显示文摘	Mathews A Ridgeway V Williamson DA	1996	Behav Res Ther1996，34，9：	1
	10	Renal cell carcinoma sub-typing by histopathology and fluorescence in situ hybridization on a needle-biopsy specimen显示文摘	Barocas DA Mathew S DelPizzo JJ	2006	BJU Int2006，99，2：	1
	11	Percutaneous stereotactic differential radiofrequency thermal rhizotomy for the treatment of trigeminal neuralgia显示文摘	Scrivani SJ Keith DA Mathews ES	1999	J Oral Maxillofac Surg1999，57，10：	1

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