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| 1 | Toxic tau: structural origins of tau aggregation in Alzheimer’s disease显示文摘Alzheimer’s disease is characterized by the extracellular accumulation of the amyloidβin the form of amyloid plaques and the intracellular deposition of the microtubule-associated protein tau in the form of neurofibrillary tangles.Most of the Alzheimer’s drugs targeting amyloidβhave been failed in clinical trials.Particularly,tau pathology connects greatly in the pathogenesis of Alzheimer’s disease.Tau protein enhances the stabilization of microtubules that leads to the appropriate function of the neuron.Changes in the quantity or the conformation of tau protein could affect its function as a microtubules stabilizer and some of the processes wherein it is involved.The molecular mechanisms leading to the accumulation of tau are principally signified by numerous posttranslational modifications that change its conformation and structural state.Therefore,aberrant phosphorylation,as well as truncation of tau protein,has come into focus as significant mechanisms that make tau protein in a pathological entity.Furthermore,the shape-shifting nature of tau advocates to comprehend the progression of Alzheimer’s disease precisely.In this review,we emphasize the recent studies about the toxic and shape-shifting nature of tau in the pathogenesis of Alzheimer’s disease. | Abdullah Al Mamun Md.Sahab Uddin Bijo Mathew Ghulam Md Ashraf | 2020 | Neural Regeneration Research2020，15，8： | 21 |
| 2 | 15-1ipoxygmmse-1 in eolorectal cancer: a review 显示文摘 | Bhattacharya S Mathew G Jayne DG el al | 2009 | Tumlmr Biol2009，30，4： | 1 |
| 3 | Postanaesthetic shivering - a new look at tramadol显示文摘 | Mathews S Al Mulla A Varghese PK | 2002 | Anaesthesia2002，57，： | 1 |
| 4 | miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma显示文摘 | Mathew LK Skuli N Muca] V ct al | 2014 | Proc Natl Acad Sci U S A2014，111，1： | 1 |
| 5 | Quinohemoproteinalcohol dehydrogenases : structure, function, andphysiology显示文摘 | TOYAMA H MATHEWS F S ADACHI 0 e t al | 2004 | Archives of Biochemistry and Biophysics2004，428，1： | 1 |
| 6 | Postanaesthetic shivering-a look at aramadol显示文摘 | Mathews S AL Mulla A Varghese PK | 2002 | Anaesthesia2002，57，4： | 1 |
| 7 | Percutaneous alcohol sclerotherapy of a hepatic hydatid cyst after balloon occlusion of a large biliary communication显示文摘 | Varro J Mathew L Athyal RP et aL | 2011 | Med Princ Pract2011，20，5： | 1 |
| 8 | Rickettsial Seroepidemiology in Farm Workers,Tianjin,People,s Republic of China显示文摘 | Zhang LJ Shan AL Mathew B | 2008 | Emerging Infectious Diseases2008，14，6： | 1 |
| 9 | Metabolic syndrome is associated with abnormal left ventrieular diastolic function independent of left ventrieular mass显示文摘 | de las Fuentes L Brown AL Mathews SJ | 2007 | European Heart Journal2007，28，5： | 1 |
| 10 | Rickettsial Seroepidemiology in Farm Workers, Tianjin, People's Republic of China 显示文摘 | Zbang LJ Shan AL Mathew B | 2008 | Emerg Infect Dis2008，14，16： | 1 |
| 11 | NKT cells enhance CD4 + and CD8 + T cell responses to soluble antigen in vivo through direct interaction with dendritic cells 显示文摘 | Hermans IF Silk JD Gileadi U Salio M Mathew B Ritter G Schmidt R Harris AL Old L Cerundolo V | 2003 | J Immunol2003，171，10： | 1 |
| 12 | An analysis of clinical outcomes using color Doppler testicular ultrasound for testicular torsion显示文摘 | Baker IrA Sigman D Mathews RI el al | 2000 | Pediatrics2000，105，3： | 1 |
| 13 | Long-range balanced electron-and hole-transport lengths in organic-inorganic CH3NH3Pb I3 显示文摘 | XING G MATHEWS N SUN S et al | 2013 | Science2013，342，6156： | 1 |
| 14 | r chiectomy for suspected microscopic tumor in patients with antbMa2 associated encephalilis 显示文摘 | Mathew RM Vandenberghe R Garcia-Merino A el al | 2002 | Neurology2002，68，90： | 1 |
| 15 | Postanaesthetic shivering a new look at tramadol 显示文摘 | Mathew S Al Mulla A Varghese PK | 2002 | Anaesthesia2002，57，2： | 1 |
| 16 | Sensitization tocommon allergens and its association with allergic disordersat age 4 years:a whole population birth cohort study显示文摘 | Arshad SH Tariq SM Mathews S eL al | 2001 | Pe-diatrics2001，108，2： | 1 |
| 17 | Rickettsial Seroepidemiology in Farm Workers,Tianjin,People's Republic of China显示文摘 | Zhang LJ Shan AL Mathew B | 2008 | Emerging Infectious Diseases2008，14，6： | 1 |
| 18 | Role-reversal exercise with Deaf Strong Hospital to teach communication compe- tency and cultural awareness显示文摘 | Mathews JL Parkhilt AL Schlehofer DA | 2011 | Am J Pharm Educ2011，75，3： | 1 |
| 19 | Expansion of anti-mesothelin specific CD4+ and CDS+ T cell responses in patients with pancreatic carcinoma显示文摘 | Chen Y Ayaru L Mathew S ~t al | 2014 | PLoS One2014，9，88： | 1 |
| 20 | Parenting attitudes and infant spanking:the influence of childhood experiences显示文摘 | Chung EK Mathew L Rothkopf AC et al | 2009 | Pediatrics2009，124，2： | 1 |
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