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| 1 | Proteomic analysis for developing new biomarkers of hepatocellular carcinoma显示文摘AIM: To identify new markers of hepatocellular carcinoma (HCC) using a proteomic analysis. METHODS: Patients with liver cirrhosis of the three most frequent etiologies: hepatitis C virus, hepatitis B virus and alcoholic liver disease, were included in the study. The samples were analysed by 2D-electrophoresis in order to determine the differential protein expression. The proteins were separated according to the charge in immobilized pH 3-10 gradient strips and then by sodium dodecyl sulfate polyacrylamide gel electrophoresis. Proteins of interest were excised, digested with trypsin and the resulting peptides were separated and identified. RESULTS: Three differentially expressed apolipoproteins (Apo) were identified based on the protein profile using proteomic techniques: Apo-A1, Apo-A4 and Apo-E. Apo-A4 levels were significantly lower in HCC than in non-HCC patients regardless of etiology (P < 0.01). Multivariate logistic regression showed that Apo-A4 and Apo-A1 were the only independent factors related to HCC diagnosis (P < 0.05). The receiver operating characteristic (ROC) curve including both Apo-A4 and Apo-A1 showed an area under the ROC of 0.944 (P < 0.001), a sensitivity of 0.89 and a specificity of 0.81 for diagnosis of HCC. CONCLUSION: Apo-A4 and Apo-A1 may be used clinically as biomarkers of HCC with a high sensibility and specificity. These findings may provide additional insights into the mechanism of HCC development and progression. | Maria Pleguezuelo Laura M Lopez-Sanchez Antonio Rodriguez-Ariza Jose L Montero Javier Briceno Ruben Ciria Jordi Muntane Manuel de la Mata | 2010 | World Journal of Hepatology2010，2，3： | 3 |
| 2 | 策略将在肝移植以后减少丙肝病毒复发显示文摘 Hepatitis C virus (HCV) is a major health problem that leads to chronic hepatitis, cirrhosis and hepatocellular carcinoma, being the most frequent indication for liver transplantation in several countries. Unfortunately, HCV re-infects the liver graft almost invariably following reperfusion, with an accelerated history of recurrence, leading to 10%-30% of patients progressing to cirrhosis within 5 years of transplantation. In this sense, some groups have even advocated for not retransplanting this patients, as lower patient and graftoutcomes have been reported. However, the management of HCV recurrence is being optimized and several strategies to reduce post-transplant recurrence could improve outcomes, decrease the rate of re-transplantation and optimize the use of available grafts. Three moments may be the focus of potential actions in order to decrease the impact of viral recurrence: the pretransplant moment, the transplant environment and the post-transplant management. In the pre-transplant setting, it is not well established if reducing the pre transplant viral load affects the risk for HCV progression after transplant. Obviously, antiviral treatment can render the patient HCV RNA negative post transplant but the long-term benefit has not yet been fully established to justify the cost and clinical risk. In the transplant moment, factors as donor age, cold ischemia time, graft steatosis and ischemia/reperfusion injury may lead to a higher and more aggressive viral recurrence. After the transplant, discussion about immunosuppression and the moment to start the treatment (prophylactic, pre-emptive or once-confirmed) together with new antiviral drugs are of interest. This review aims to help clinicians have a global overview of posttransplant HCV recurrence and strategies to reduce its impact on our patients. | Ruben Ciria María Pleguezuelo Shirin Elizabeth Khorsandi Diego Davila Abid Suddle Hector Vilca-Melendez Sebastian Rufian Manuel de la Mata Javier Briceo Pedro López Cillero Nigel Heaton | 2013 | World Journal of Hepatology2013，5，5： | 2 |
| 3 | Information technology and sustained competitive advantage: a resource-based analysis显示文摘 | MATA F J FUERST W L BARNEY J B | 1995 | MIS Quarterly1995，12，： | 1 |
| 4 | Wireless- Control Strategy for Parallel Operation of Distributed-Gener- ation Inverters显示文摘 | J M Guerrero J Matas L Cz de Vicuna | 2006 | IEEE Transactions on Industrial lectron- ics2006，53，5： | 1 |
| 5 | Integration of a consis- tency control module within a consensus model 显示文摘 | Chiclana F Mata F Martinez L | 2008 | Interna- tional Journal of Uncertainty Fuzziness and Knowledge-Based Systems2008，16，1： | 1 |
| 6 | Wireless control strategy for parallel operation of distributed generation inverters显示文摘 | Guerrero J M Matas J Devicuna L G | 2006 | IEEE Transactions on Industrial Electronics2006，53，5： | 1 |
| 7 | Exercise holds immediate benefits for affect and cognition in younger and older adults显示文摘 | HOGAN C L MATA J CARSTENSEN L L | 2013 | Psycholo- gy and aging2013，28，2： | 1 |
| 8 | Nitric Oxide Induces Stomatal Closure and Enhances the Adaptive Plant Responses Against Drought Stress 显示文摘 | Mata C G Lamattina L | 2001 | Plant Physiology2001，1261，： | 1 |
| 9 | Nitric oxide induces stomatal closure and enhances the adaptive plant responses against drought stress显示文摘 | Garcia Mata C Lamattina L | 2001 | Plant Physiology2001，126，： | 1 |
| 10 | Information Technology and Sustained Competitive Advantage: A Resource-based Analysis 显示文摘 | Mata F J Fuerst W L Barney J B | 1995 | MIS Quarterly1995，，： | 1 |
| 11 | Output impedance design of parallel-connected UPSinverters with wireless load-sharing control显示文摘 | Guerrero J M de Vicuna L G Matas J | 2005 | IEEE Transactions on Industrial Electronics2005，52，4： | 1 |
| 12 | Nitric oxide induces stomatal closure and enhances the adaptive plant responses against drought stress显示文摘 | MATA C G LAMATTINA L | | 0，，： | 1 |
| 13 | An adaptive consensus support model for group decision- making problems in a multigranular fuzzy linguistic context显示文摘 | Mata F Martinez L Herrera-Viedma E | 2009 | IEEE Transactions On Fuzzy Systems2009，17，2： | 1 |
| 14 | Comparison of radioimmunoassay and enzyme immunoassay kits for detection of Legionella pneumophila serogroup 1 antigen in both concentrated and nonconcentrated urine samples显示文摘 | Dominguez JA Matas L Manterola JM | 1997 | J Clin Microbiol1997，35，6： | 1 |
| 15 | Nitric oxide induces stomatal closure and enhances the adaptive plant responses against drought stress 显示文摘 | Garcia - Mata C Lamattina L | 2001 | Plant Physiol2001，126，： | 1 |
| 16 | Gold (Ⅲ) biosorption and bioreduction with the brown alga Fueus vesiculosus 显示文摘 | Mata Y N Torres E B16zquez M L Ballester A GonzOlez F Mufioz J A | 2009 | Journal of Hazardous Materials2009，166，23： | 1 |
| 17 | Output impedance design of parallel-connected UPS Inverters with wireless Load-sharing control显示文摘 | GUERRERO J M DE VICUNA L G MATAS J | 2005 | IEEE Trans on Industrial Electronics2005，52，4： | 1 |
| 18 | Host and envi- ronmental factors influencing respiratory secretion of pro-wheezing biomarkers in preterm children 显示文摘 | Matas V San Feliciano L Fern6ndez JE | 2012 | Pediatr Allergy Immunol2012，23，5： | 1 |
| 19 | Decentralized control for parallel operation of distribution generation inverter using resistive output impedance显示文摘 | GUERRERO J M MATAS J DE VICUNA L G | 2007 | IEEE Trans on Industrial Electronics2007，54，2： | 1 |
| 20 | A consensus support system model for group decision-making problems with multigranular linguistic preference relations显示文摘 | Herrera-Viedma E Martínez L Mata F | | 0，，05： | 1 |
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