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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | Glucose metabolism: Fo- cus on gut microbiota, the endocannabinoid system and beyond 显示文摘 | Cani PD Geurts L Matamoros S | 2014 | Diabetes Metab2014，40，4： | 1 |
| 3 | Fatigue behavior of welded coverplates treated with Ultrasonic Impact Treatment and bolting显示文摘 | Brian Vilhauer Caroline R. Bennett Adolfo B. Matamoros Stanley T. Rolfe | 2011 | Engineering Structures2011，，： | 1 |
| 4 | Experimental evaluation of design procedures for shear strength of deep reinforced concrete beams显示文摘 | Aguilar G Matamoros A B Parra-Montesinos G J | 2002 | ACI Journal2002，99，4： | 1 |
| 5 | Develop- ment of intestinal microbiota in infants and its impact on health显示文摘 | Matamoros S Gras-Leguen C Le Vacon F | 2013 | Trends Microbiol2013，21，4： | 1 |
| 6 | Factors associated with mortality in pediatric in-hospital eardiac arrest: a prospective multleenter muhinational observational study显示文摘 | L6pez-Heree J Del Castillo J Matamoros M | 2013 | Intensive Care Med2013，39，2： | 1 |
| 7 | Occurrence and fate of benzothiazoles and benzotriazoles in constructed wetlands显示文摘 | MATAMOROS V JOVER E BAYONA J | 2010 | 61(1):191-1982010，61，1： | 1 |
| 8 | Insertions and deletions in HIV-1 reverse tran- scriptase: consequences for drug resistance and viral fitness显示文摘 | Menendez-Arias L Matamoros T Cases-Gonzalez C E | 2006 | Curr Pharm Des2006，12，15： | 1 |
| 9 | Behavior of emerging pollutants in constructed wetlands 显示文摘 | Victor Matamoros J M B | 2008 | Hdb Envimment Chemistry2008，5，2： | 1 |
| 10 | Capability of microalgae-based wastewater treat- ment systems to remove emerging organic contami- nants A pilot-scale study显示文摘 | MATAMOROS V GUTIERREZ R FERRER I | 2015 | Journal of Hazardous Materials2015，288，2： | 1 |
| 11 | Simulation of the water and heat management in proton exchange membrane fuel cells 显示文摘 | Luis Matamoros Dieter Braggemann | 2006 | Journal of Power Sources2006，161，1： | 1 |
| 12 | Drift-dependent confinement requirements for reinforced concrete columns under cyclic loading 显示文摘 | Brachmann L Browning J Matamoros A | 2004 | ACI Structural Journal2004，101，5： | 1 |
| 13 | Evaluation of PPCPs removal in a combined anaerobic digester-constructed wetland pilot plant treating urban wastewater显示文摘 | C. Reyes-Contreras V. Matamoros I. Ruiz M. Soto J.M. Bayona | 2011 | Chemosphere2011，，9： | 1 |
| 14 | Selection and evaluation of seafood-borne psyehrotrophie lactic acid bacteria as inhibitors of pathogenic and spoilage bacteria显示文摘 | Matamoros S Pilet M F Gigout F | 2009 | Food Mierobiology2009，26，： | 1 |
| 15 | Selection and Evaluation of Seafood-borne Psyehrotrophic Lactic Acid Bacteria as Inhibitors of Pathogenic and Spoilage Bacteria显示文摘 | Matamoros S Pilet M F Gigout F | 2009 | Food Microbiology2009，26，6： | 1 |
| 16 | Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol- dependence severity 显示文摘 | Leclercq S Matamoros S Cani PD | 2014 | Proc Natl Acad Sci U S A2014，111，42： | 1 |
| 17 | Drift limits of high-strength concrete columns subjected to load reversals 显示文摘 | Matamoros A B Sozen M A | 2003 | Journal of Structural Engineering ASCE2003，129，3： | 1 |
| 18 | Design of Simply Supported Deep Beams Using Strut-and-Tie Models显示文摘 | Adolfo B Matamoros Kuok Hong Wong | 2003 | ACI Structural Journal2003，100，6： | 1 |
| 19 | Selection and evaluation of seafood-borne psychrotrophic lactic acid bacteria as inhibitors of pathogenic and spoilage bacteria显示文摘 | Matamoros S Pilet M F Gigout F | 2009 | Food Microbiology2009，26，6： | 1 |
| 20 | Design ofSimply Supported Deep Beams Using Strut-and-TieModels显示文摘 | Matamoros Adolfo B Wong Hong Kuok | 2003 | ACI Structural Journal2003，100，6： | 1 |
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