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| 1 | Factors predicting survival in patients with proximal gastric carcinoma involving the esophagus显示文摘AIM:To investigate the clinicopathologic features which predict surgical overall survival in patients with proximal gastric carcinoma involving the esophagus (PGCE).METHODS:Electronic pathology database established in the Department of Pathology of the Nanjing Drum Tower Hospital was searched for consecutive resection cases of proximal gastric carcinoma over the period from May 2004 through July 2009.Each retrieved pathology report was reviewed and the cases with tumors crossing the gastroesophageal junction line were selected as PGCE.Each tumor was re-staged,following the guidelines on esophageal adenocarcinoma,according to the 7th edition of the American Joint Commission on Cancer Staging Manual.All histology slides were studied along with the pathology report for a retrospective analysis of 13 clinicopathologic features,i.e.,age,gender,Helicobacter pylori (H.pylori ) infection,surgical modality,Siewert type,tumor Bormann's type,size,differentiation,histology type,surgical margin,lymphovascular and perineural invasion,and pathologic stage in relation to survival after surgical resection.Prognostic factors for overall survival were assessed with uniand multi-variate analyses.RESULTS:Patients' mean age was 65 years (range:47-90 years).The male:female ratio was 3.3.The 1-,3and 5-year overall survival rates were 87%,61% and 32%,respectively.By univariate analysis,age,male gender,H.pylori ,tumor Bormann's type,size,histology type,surgical modality,positive surgical margin,lymphovascular invasion,and pT stage were not predictive for overall survival;in contrast,perineural invasion (P = 0.003),poor differentiation (P = 0.0003),> 15 total lymph nodes retrieved (P = 0.008),positive lymph nodes (P = 0.001),and distant metastasis (P = 0.005) predicted poor post-operative overall survival.Celiac axis nodal metastasis was associated with significantly worse overall survival (P = 0.007).By multivariate analysis,≥ 16 positive nodes (P = 0.018),lymph node ratio > 0.2 (P = 0.003),and overall pathologic stage (P = 0.002) were independent predictors for poor overall survival after resection.CONCLUSION:Patients with PGCE showed worse overall survival in elderly,high nodal burden and advanced pathologic stage.This cancer may be more accurately staged as gastric,than esophageal,cancer. | Yi-Fen Zhang Jiong Shi Hui-Ping Yu An-Ning Feng Xiang-Shan Fan Gregory Y Lauwers Hiroshi Mashimo Jason S Gold Gang Chen Qin Huang | 2012 | World Journal of Gastroenterology2012，18，27： | 12 |
| 2 | Endoscopic management of chronic radiation proctitis显示文摘Chronic radiation proctopathy occurs in 5%-20% of patients following pelvic radiotherapy. Although many cases resolve spontaneously,some lead to chronic symptoms including diarrhea,tenesmus,urgency and persistent rectal bleeding with iron deficiency anemia requiring blood transfusions. Treatments for chronic radiation proctitis remain unsatisfactory and the basis of evidence for various therapies is generally insuff icient. There are very few controlled or prospective trials,and comparisons between therapies are limited because of different evaluation methods. Medical treatments,including formalin,topical sucralfate,5-amino salicylic acid enemas,and short chain fatty acids have been used with limited success.Surgical management is associated with high morbidity and mortality. Endoscopic therapy using modalities such as the heater probe,neodymium:yttrium-aluminium-garnet laser,potassium titanyl phosphate laser and bipolar electrocoagulation has been reported to be of some benef it,but with frequent complications.Argon plasma coagulation is touted to be the preferred endoscopic therapy due to its eff icacy and safety profile.Newer methods of endoscopic ablation such as radiofrequency ablation and cryotherapy have been recently described which may afford broader areas of treatment per application,with lower rate of complications.This review will focus on endoscopic ablation therapies,including such newer modalities,for chronic radiation proctitis. | Tarun Rustagi Hiroshi Mashimo | 2011 | World Journal of Gastroenterology2011，17，41： | 8 |
| 3 | Cervical inlet patch-optical coherence tomography imaging and clinical significance显示文摘AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were included.White light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT system.The OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(GI)tract.Standard hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux disease.The CIP region appeared as a pink circular lesion in the upper esophagus under white light endoscopy.OCT imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum bulb.Microstructures,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E histology.These results demonstrated the feasibility of using OCT to evaluate GI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP. | Chao Zhou Tejas Kirtane Tsung-Han Tsai Hsiang-Chieh Lee Desmond C Adler Joseph M Schmitt Qin Huang James G Fujimoto Hiroshi Mashimo | 2012 | World Journal of Gastroenterology2012，18，20： | 3 |
| 4 | Durability of Radiofrequency Ablation in Barrett’s Esophagus With Dysplasia显示文摘 | Nicholas J. Shaheen Bergein F. Overholt Richard E. Sampliner Herbert C. Wolfsen Kenneth K. Wang David E. Fleischer Virender K. Sharma Glenn M. Eisen M. Brian Fennerty John G. Hunter Mary P. Bronner John R. Goldblum Ana E. Bennett Hiroshi Mashimo Richard I | 2011 | Gastroenterology2011，，2： | 3 |
| 5 | A pilot study to assess the safety and efficacy of carbon dioxide insufflation during colorectal endoscopic submucosal dissection with the patient under conscious sedation显示文摘 | Yutaka Saito Toshio Uraoka Takahisa Matsuda Fabian Emura Hisatomo Ikehara Yumi Mashimo Tsuyoshi Kikuchi Takahiro Kozu Daizo Saito | 2007 | Gastrointestinal Endoscopy2007，，3： | 3 |
| 6 | Characterization of buried glands before and after radiofrequency ablation by using 3-dimensional optical coherence tomography (with videos)显示文摘 | Chao Zhou Tsung-Han Tsai Hsiang-Chieh Lee Tejas Kirtane Marisa Figueiredo Yuankai K. Tao Osman O. Ahsen Desmond C. Adler Joseph M. Schmitt Qin Huang James G. Fujimoto Hiroshi Mashimo | 2012 | Gastrointestinal Endoscopy2012，，1： | 2 |
| 7 | Centrifuge model test of tunnel face reinforcement by bolting显示文摘 | Hirohisa Kamata Hideto Mashimo | 2003 | Tunnelling and Underground Space Technology incorporating Trenchless Technology Research2003，，2： | 2 |
| 8 | The effect of positive end-expiratory pressure and continuous positive airway pressure on the oxygenation and shunt fraction during one-lung ventilation with propofol anesthesia显示文摘 | Fujiwara M Abe K Mashimo T | 2001 | J Clin Anesth2001，13，7： | 1 |
| 9 | P2X4 receptor expression in a rat model of trigeminal neuropathic pain显示文摘 | Nakai K Nakae A Oba S Mashimo T Ueda K | 2010 | Neu- roreport2010，21，8： | 1 |
| 10 | Semaphorin Ⅲ is needed for normal patterning and growth of nerves,bones and heart显示文摘 | Behar O Golden JA Mashimo H | | 0，，6600： | 1 |
| 11 | A pneumopeficardium caused by gastric ulcer perforation显示文摘 | Taniyama D Miyamoto K Mashimo S | 2013 | Intern Med2013，52，： | 1 |
| 12 | Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular seneseence显示文摘 | Shibanuma M Mashimo J Kuroki T Nose K | 1994 | J Biol Chem1994，269，26： | 1 |
| 13 | Metastable BCC and FCC alloy bulk bodies in Fe-Cu system prepared by mechanical alloying and shock oompression显示文摘 | HUANG X S MASHIMO T | 1999 | J Alloys Comp1999，288，1： | 1 |
| 14 | Local anaesthetics have different mechanisms and sites of action at the re-combinant N-methyl-D-aspartate(NMDA)receptors显示文摘 | Sugimoto M Uchida I Mashimo T | 2003 | Br J Pharmacol2003，138，： | 1 |
| 15 | The expression of the KAI1 gene,a tumor metastasis suppressor,is directly activated by p53显示文摘 | Mashimo T Waabe M Hirota S | 1998 | Proc Natl Acad Sci USA1998，95，11： | 1 |
| 16 | Mapping of four simple sequence repeat (SSR) markers on rat chromosome 4显示文摘 | Mashimo T Nabika T Kitada K | 2000 | Hypertens Res2000，23，1： | 1 |
| 17 | Centrifuge model test of tunnel face reinforcement by bolting 显示文摘 | KAMATA H MASHIMO H | 2003 | Tunnelling and Underground Space Technology2003，18，3： | 1 |
| 18 | Decrease in the expression of a novel TGF betal-inducible and ras-recision gene, TSC-36, in human cancer cells 显示文摘 | Mashimo J Maniwa R Sugino H | 1997 | Cancer Lett1997，113，12： | 1 |
| 19 | Microwave dielectric properties of solid and liquid foods investigated by time-domain reflec- tometry显示文摘 | Miura S Yagihara A Mashimo S | 2003 | Journal of Food Science2003，68，4： | 1 |
| 20 | Lower esophageal sphincter is achalasic in nNOS(-/-) and hypotensive in W/W(v) mutant mice显示文摘 | SIVARAO D V MASHIMO H L THATTE H S | 2001 | Gastroenterology2001，121，1： | 1 |
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