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| 1 | Antiproliferative role of Indig ofera aspalathoides on 20 methylcholanthrene induced fibrosarcoma in rats显示文摘Objective:To find out the anticancer effect of indigofera aspalathoides(L.aspalathoides)on20-methylcholanthrene induced fibrosarcoma in rats.Methods:Fibrosarcoma was induced in Wistar strain male albino rats by 2O-methylcholanthrene.Intraperitoneous(i.p.)administration of250 mg/kg body weight/day of aqueous extract of I.aspalathoides for 30 d effectively suppressed chemically induced tumors.Parameters such as body weight,liver and kidney weight,tumor weight,mean survival time,behavioral changes,blood glucose,blood glycogen and marker enzymes such as alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),acid phosphatase(ACP)and 5'-nucleiotidase(5'-NT)in serum,liver and kidney and lipid profiles such as total cholesterel,phospholipids,free fatty acids in liver and kidney of control and experimental animals were studied.Results:Fibrosarcoma bearing animals were ferocious and anxious.The mean survival time was found to increase after the treatment.The body weights were significantly decreased(P<0.001)in groupⅡfibrosarcoma animals which steadily increased after the treatment with I.aspalathoides.The liver and kidney weights were significantly increased whereas the tumor weights decreased as compared to the weights in untreated fibrosarcoma bearing rats.The blood glucose and the liver and kidney glycogen levels were found to decrease significantly(P<0.001)in groupⅡanimals.Elevated activities of marker enzymes were observed in serum,liver and kidney of fibrosarcoma bearing GroupⅡanimals which were normalize after I.aspalathoides treatment.In the liver and kidney of GroupⅡanimals the total cholesterol increased whereas the pbospbolipids and free fatty acid levels decreased(P<0.001)which were normalized after treatment.Conclusions:The treatment by I.aspalathoides on fihrosarcoma bearing rats has improved the levels of various parameters indicating its antiproliferative and anticancer activity. | Sivagnanam Selva Kumar Mudiganti Ram Krishna Rao Maruthaiveeran Periyasamy Balasubramanian | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，12： | 2 |
| 2 | Kaempferol ameliorates aflatoxin B1 (AFB 1 ) induced hepatocellular carcinoma through modifying metabolizing enzymes, membrane bound ATPases and mitochondrial TCA cycle enzymes显示文摘 | Kulanthaivel Langeswaran Rajendran Revathy Subbaraj Gowtham Kumar Shanmugam Vijayaprakash Maruthaiveeran Periyasamy Balasubramanian | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，，3： | 1 |
| 3 | Protective efficacy of dietary D-pinitol on hepatic and renal tissues during experimental breast cancer in rats challenged with 7,12-Dimethylbenz(a)anthracene:A biochemical approach显示文摘 | Thamaraiselvan Rengarajan Natarajan Nandakumar Maruthaiveeran Periyasamy Balasubramanian | 2012 | Biomedicine&Aging Pathology2012，2，： | 1 |
| 4 | D-Pinitol a low- molecular cyclitol prevents 7, 12-Dimethylbenz anthracene induced experimental breast cancer through regulating anti apoptotic protein Bcl-2, mitochondrial and carbohydrate key metabolizing enzymes显示文摘 | Thamaraiselvan Rengarajan Natarajan Nandakumar Maruthaiveeran Periyasamy Balasubramanian | 2012 | Biomedicine & Preventive Nutrition2012，2，： | 1 |
| 5 | Effects of Terminalia arjuna bark extract on apoptosis of human hepatoma cell line HepG2显示文摘瞄准:调查尾器 arjuna 的效果(T。arjuna ) 人的肝细胞瘤房间线(HepG2 ) 和它在 apoptosis 的正式就职的可能的角色上的摘录。方法:人的肝细胞瘤房间与 T 的 ethanolic 摘录的不同集中被对待。arjuna 和它的细胞毒性效果被尝试平底锅蓝色排除方法和 lactate 脱氢酶漏试金测量。Apoptosis 被光和荧光分析显微镜的方法,和 DNA 破碎。apoptosis 的机制与 p53 和 caspase-3 蛋白质的表示被学习。谷胱甘肽(GSH ) 内容也在 T 以后在 HepG2 房间被测量。arjuna 处理。结果:T。arjuna 以一种集中依赖者方式禁止了 HepG2 房间的增长。Apoptotic 形态学在与 T 对待的 HepG2 房间被观察。在 60 和 100 mg/L 的集中的 arjuna。DNA 破碎, p53 的累积和 procaspase-3 蛋白质的劈开与 T 在处理以后在 HepG2 房间被观察。arjuna。GSH 的弄空在与 T 对待的 HepG2 房间被观察。arjuna。结论:T。arjuna 在 HepG2 房间在试管内导致了细胞毒性。HepG2 房间的 Apoptosis 可能由于 DNA 损坏和 apoptotic 蛋白质的表示。GSH 的弄空可以涉及 HepG2 房间的 apoptosis 的正式就职。 | Sarveswaran Sivalokanathan Marati Radhakrishnan Vijayababu Maruthaiveeran Periyasamy Balasubramanian | 2006 | World Journal of Gastroenterology2006，12，7： | 0 |
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