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| 1 | Characterization of six tumorsuppressor genes and microsatellite instability in hepatocellular carcinomain southern African blacks显示文摘AIM To analyse cumulative loss of heterozygosity (LOH) of chromosomal regions and tumor suppressor genes in hepatocellular carcinomas (HCCs) from 20 southern African blacks. METHODS p53, RB1, BRCA1, BRCA2, WT1 and E cadherin genes were analysed for LOH, and p53 gene was also analysed for the codon 249 mutation, in tumor and adjacent non tumorous liver tissues using molecular techniques and 10 polymorphic microsatellite markers. RESULTS p53 codon 249 mutation was found in 25% of the subjects, as was expected, because many patients were from Mozambique, a country with high aflatoxin B 1 exposure. LOH was found at the RB1, BRCA2 and WT1 loci in 20%(4/*!20) of the HCCs, supporting a possible role of these genes in HCC. No LOH was evident in any of the remaining genes. Reports of mutations of p53 and RB1 genes in combination, described in other populations, were not confirmed in this study. Change in microsatellite repeat number was noted at 9/*!10 microsatellite loci in different HCCs, and changes at two or more loci were detected in 15%(3/*!20) of subjects. CONCLUSION We propose that microsatellite/genomic instability may play a role in the pathogenesis of a subset of HCCs in black Africans. | Martins C Kedda MA Kew MC | 1999 | World Journal of Gastroenterology1999，5，6： | 21 |
| 2 | Predominance of Th2 cytokines, CXC chemokines and innate immunity mediators at the mucosal level during severe respiratory syncytial virus infection in children 显示文摘 | Bermejo Martin JF Garcia Arevalo MC De Lejarazu | 2007 | Eur Cytokine Netw2007，8，3： | 1 |
| 3 | Prognostic significance of progesterone receptor-positive tumor cells within immunohis- tochemically defined luminal a breast cancer 显示文摘 | Prat A Cheang MC Martin M | 2013 | J Clin On- col2013，31，2： | 1 |
| 4 | Denosumab for prevention of fractures in postmenopausal women with osteoporosis显示文摘 | CUMMINGS S R MARTIN J S Mc CLUNG M R | 2009 | The New England Journal of Medicine2009，361，8： | 1 |
| 5 | Ex vivo cytokine and memory T cell responses to the 42-kDa fragment of Phismodium falciparum merozoite surface protein-1 in vaccinated volunteers 显示文摘 | Huaman MC Martin LB Malkin E | 2008 | J Immunol2008，180，3： | 1 |
| 6 | Liver fatty-acid-binding (L-FABP) gene ablation alters liver bile acid metabolism in male mice 显示文摘 | Martin GG AtshavesBP Mc Intosh A | 2005 | Biochem J2005，391，3： | 1 |
| 7 | Indapamide(Natrilix):The agent of choice in the trentment of recurrent renal calculi associated with idiopathic hypercalciuria显示文摘 | MC Martins AM Meyers NA Whalley | 1996 | Br J Urol1996，78，2： | 1 |
| 8 | Spontaneous human adult stem cell transformation 显示文摘 | Rubio D Garcia-Castro J Martin MC | 2005 | Cancer Res2005，65，： | 1 |
| 9 | Assessment ofTopoisomerase II alpha status in breast cancer by quantitativePCR,gene expression microarrays,immunohistochemistry,andfluorescence in situ hybridization显示文摘 | Romero A Martin M Cheang MC | 2011 | Am J Pathol2011，178，4： | 1 |
| 10 | On CK2 regulation of chronic lymphocytic leukemia cell viability显示文摘 | Martins LR Lucio P Silva MC | | 0，，1： | 1 |
| 11 | Albumin and fibrinogen adsorption on PU-PHEMA surfaces显示文摘 | Wang D Ji J | 2003 | Biomaterials2003，24，12： | 1 |
| 12 | A donor-site preference utility study for three gaps used in lower extremity microvascular recon- struction 显示文摘 | Yeung LC Ellstrom CL Martin MC | 2011 | Ann Plast Surg2011，66，1： | 1 |
| 13 | First clinical isolate of vancomycin-intermediate Staphylococcus aureus in a French hospital显示文摘 | Ploy MC Grelaud C Martin C | 1998 | Lancet1998，351，： | 1 |
| 14 | Estimation of intra- abdominal pressure by bladder pressure measurement: validity and methodology显示文摘 | Fusco MA Martins RS Chang MC | 2001 | J Trauma2001，50，： | 1 |
| 15 | qPCR for quantitative detection of tyramine-producing bacteria in dairy products 显示文摘 | Ladero V Martinez N Martin MC Ferndndez M Alvarez MA | 2010 | Food Res Int2010，43，1： | 1 |
| 16 | Cytochrome P450 1B1 (CYP1B1) is overexpressed in human colon adenocarcinomas relative to normal colon:implications for drug development显示文摘 | Gibson P Gill JH Khan PA Seargent JM Martin SW Batman PA Griffith J Bradley C Double JA Bibby MC Loadman PM | 2003 | Mol Cancer Ther2003，2，6： | 1 |
| 17 | Prescribing exercise at varied levels of intensity and frequency: a randomized trial 显示文摘 | Duncan GE Anton SD Sydeman SJ Newton RL Jr Corsica JA Durning PE Ketterson TU Martin AD Limaeher MC Perri MG | 2005 | Arch Intern Med2005，165，20： | 1 |
| 18 | Interleukin-10 and the monocyte-macrophage-induced inflammatory response in septic shock显示文摘 | Gomez J Martin MC Sauri R | 1995 | J Infect Dis1995，171，： | 1 |
| 19 | Reproductive and other risk fac- tors for adenocarcinorna of the cervix, results from a population - based, case - control study ( California, United States)显示文摘 | Ursin G Pike MC Martin S et a l | 1996 | Cancer Causes Control1996，7，3： | 1 |
| 20 | Identifica- tion by a differential proteomic approach of heat shock protein 27 as a potential marker of atherosclerosis 显示文摘 | Martin - Ventura JL Duran MC Blanco - Colio LM | 2004 | Circulation2004，110，15： | 1 |
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