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2篇 您的检索式:作者名="Markus Langner"
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1Cancer risk in IBD: How to diagnose and how to manage DALM and ALM显示文摘The risk of developing neoplasia leading to colorectal cancer is significantly increased in ulcerative colitis (UC) and most likely in Crohn's disease. Several endoscopic surveillance strategies have been implemented to identify these lesions. The main issue is that colitisassociated neoplasms often occurs in flat mucosa, often being detected on taking random biopsies rather than by identification of these lesions via endoscopic imaging. The standard diagnostic procedure in long lasting UC is to take four biopsies every 10 cm. Image enhancement methods, such as chromoendoscopy and virtual histology using endomicroscopy, have greatly im- proved neoplasia detection rates and may contribute toreduced random biopsies by taking targeted 'smart' biopsies. Chromoendoscopy may effectively be performed by experienced endoscopists for routine screening of UC patients. By contrast, endomicroscopy is often only available in selected specialized endoscopic centers. Importantly, advanced endoscopic imaging has the poten- tial to increase the detection rate of neoplasia whereas the interplay between endoscopic experience and interpretation of histological biopsy evaluation allows the physician to make a proper diagnosis and to find the appropriate therapeutic approach. Colitis-associated intraepithelial neoplasms may occur in flat mucosa of endoscopically normal appearance or may arise as dysplasia-associated lesion or mass (DALM), which may be indistinguishable from sporadic adenomas in healthy or non-colitis mucosa [adenoma-like mass (ALM)]. The aim of this review was to summarize endoscopic and histological characteristics of DALM and ALM in the context of therapeutic procedures.Helmut Neumann Michael Vieth Cord Langner Markus F Neurath Jonas Mudter 2011World Journal of Gastroenterology2011,17,27:6
2Polymer nanofibre composite nonwovens with metal-like electrical conductivity显示文摘Bendable and breathable polymer nanofibre nonwovens with metal-like electrical conductivity are required for lightweight electrodes and electric shielding design with applications in batteries,functional textiles,sensors,cars,aerospace,constructions,mobile phones,and medical devices.Metal-like conductivity in polymer nonwovens has not been achieved till now due to the limitation of the existing processing techniques.We show here,the metal-like electrical conductivity of 750,000 S/m in polyacrylonitrile(PAN),poly(ε-caprolactone)(PCL)nonwoven using very low content of silver nanowires(AgNW;3.35 vol%).The key to the high conductivity was the homogenous distribution of AgNW in nonwoven made by wet-laid process using short electrospun fibre and AgNW dispersion.Above a threshold of 0.36 vol%AgNW,the conductivity of the nonwoven increased by seven orders of magnitude,which we attribute to the onset of percolation of the AgNW.Our nonwoven-AgNW composites show fast heating and cooling within a few seconds at a voltage of 1.1 V,which is in the range of portable devices.These composites are also breathable and bendable.The electrical conductivity was independent of the bending angle of the composite,which is important for applications mentioned above and would help other scientists to design new conductive materials in the future.Steffen Reich Matthias Burgard Markus Langner Shaohua Jiang Xueqin Wang Seema Agarwal Bin Ding Jianyong Yu Andreas Greiner 2018npj Flexible Electronics2018,2,1:1
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