|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates显示文摘Dear Editor,Omicron(B.1.1.529),is a heavily mutated and highly contagious SARS-CoV-2 variant,which is currently causing large outbreaks in many countries.Protection provided by current vaccines is substantially reduced against Omicron.1,2 Moreover,many immunocompromised individuals cannot effectively be protected by vaccines.3 Hence,antiviral therapies will be essential to protect the most vulnerable individuals from severe COVID-19. | Denisa Bojkova Marek Widera Sandra Ciesek Mark N.Wass Martin Michaelis Jindrich Cinatl Jr | 2022 | Cell Research2022，32，3： | 10 |
| 2 | Direct laser writing of volumetric gradient index lenses and waveguides显示文摘Direct laser writing(DLW)has been shown to render 3D polymeric optical components,including lenses,beam expanders,and mirrors,with submicrometer precision.However,these printed structures are limited to the refractive index and dispersive properties of the photopolymer.Here,we present the subsurface controllable refractive index via beam exposure(SCRIBE)method,a lithographic approach that enables the tuning of the refractive index over a range of greater than 0.3 by performing DLW inside photoresist-filled nanoporous silicon and silica scaffolds.Adjusting the laser exposure during printing enables 3D submicron control of the polymer infilling and thus the refractive index and chromatic dispersion.Combining SCRIBE’s unprecedented index range and 3D writing accuracy has realized the world’s smallest(15μm diameter)spherical Luneburg lens operating at visible wavelengths.SCRIBE’s ability to tune the chromatic dispersion alongside the refractive index was leveraged to render achromatic doublets in a single printing step,eliminating the need for multiple photoresins and writing sequences.SCRIBE also has the potential to form multicomponent optics by cascading optical elements within a scaffold.As a demonstration,stacked focusing structures that generate photonic nanojets were fabricated inside porous silicon.Finally,an all-pass ring resonator was coupled to a subsurface 3D waveguide.The measured quality factor of 4600 at 1550 nm suggests the possibility of compact photonic systems with optical interconnects that traverse multiple planes.SCRIBE is uniquely suited for constructing such photonic integrated circuits due to its ability to integrate multiple optical components,including lenses and waveguides,without additional printed supports. | Christian R.Ocier Corey A.Richards Daniel A.Bacon-Brown Qing Ding Raman Kumar Tanner J.Garcia Jorik van de Groep Jung-Hwan Song Austin J.Cyphersmith Andrew Rhode Andrea N.Perry Alexander J.Littlefield Jinlong Zhu Dajie Xie Haibo Gao Jonah F.Messinger Mark L.Brongersma Kimani C.Toussaint Jr Lynford L.Goddard Paul V.Braun | 2020 | Light(Science & Applications)2020，9，1： | 6 |
| 3 | Magnetic resonance angiography for the primary diagnosis of pulmonary embolism: A review from the international workshop for pulmonary functional imaging显示文摘Pulmonary contrast enhanced magnetic resonance angiography(CE-MRA) is useful for the primary diagnosis of pulmonary embolism(PE). Many sites have chosen not to use CE-MRA as a first line of diagnostic tool for PE because of the speed and higher efficacy of computerized tomographic angiography(CTA). In this review, we discuss the strengths and weaknesses of CEMRA and the appropriate imaging scenarios for the primary diagnosis of PE derived from our unique multiinstitutional experience in this area. The optimal patient for this test has a low to intermediate suspicion for PE based on clinical decision rules. Patients in extremis are not candidates for this test. Younger women(< 35 years of age) and patients with iodinated contrast allergies are best served by using this modality We discuss the history of the use of this test, recent technical innovations, artifacts, direct and indirect findings for PE, ancillary findings, and the effectiveness(patient outcomes) of CE-MRA for the exclusion of PE. Current outcomes data shows that CE-MRA and NM V/Q scans are effective alternative tests to CTA for the primary diagnosis of PE. | Nanae Tsuchiya Edwin JR van Beek Yoshiharu Ohno Hiroto Hatabu Hans-Ulrich Kauczor Andrew Swift Jens Vogel-Claussen Jürgen Biederer James Wild Mark O Wielpütz Mark L Schiebler | 2018 | World Journal of Radiology2018，10，6： | 4 |
| 4 | Intraductal papillary mucinous neoplasm and the pancreatic incidentaloma显示文摘Asymptomatic pancreatic lesions(APL) are a commonly encountered problem in today's pancreatic surgical practices.Current literature regarding etiologies and incidence of APLs,particularly intraductal papillary mucinous neoplasm(IPMN),is presented.APLs constitute a wide spectrum of pathology(solid/cystic,benign/premalignant/malignant) but,overall,IPMN is now the most common diagnosis.The Sendai Guidelines and their function as a basis for risk stratification in branch duct IPMN are presented.The importance of traditionally analyzed cyst characteristics including size,presence of mucin or nodules and cyst fluid aspirate as indicators of malignancy is emphasized,noting also the potential correlation of main duct dilatation,thickened septae and elevated cyst fluid CEA with increased risk of malignancy.Current complication rates after resection of APLs are reviewed and found to be generally equivalent to those for symptomatic resections.A potential multidisciplinary treatment strategy is offered considering the costs of surgery versus repeated imaging or follow up endoscopy for these lesions.The decision for intervention is ultimately based on the Sendai Guidelines in the context of the individual patient. | Tara S Kent Charles M Vollmer Jr Mark P Callery | 2010 | World Journal of Gastrointestinal Surgery2010，2，10： | 3 |
| 5 | Inflammation-related gene expression profiles of salivary extracellular vesicles in patients with head trauma显示文摘At present,there is no reliable biomarker for the diagnosis of traumatic brain injury(TBI).Studies have shown that extracellular vesicles released by damaged cells into biological fluids can be used as potential biomarkers for diagnosis of TBI and evaluation of TBI severity.We hypothesize that the genetic profile of salivary extracellular vesicles in patients with head trauma differs from that in uninjured subjects.Findings from this hypothesis would help investigate the severity of TBI.This study included 19 subjects,consisting of seven healthy controls who denied history of head trauma,six patients diagnosed with concussion injury from an outpatient concussion clinic,and six patients with TBI who received treatment in the emergency department within 24 hours after injury.Real-time PCR analysis of salivary extracellular vesicles in participants was performed using TaqMan Human Inflammation array.Gene expression analysis revealed nine upregulated genes in emergency department patients(LOX5,ANXA3,CASP1,IL2RG,ITGAM,ITGB2,LTA4H,MAPK14,and TNFRSF1A)and 13 upregulated genes in concussion clinic patients compared with healthy participants(ADRB1,ADRB2,BDKRB1,HRH1,HRH2,LTB4R2,LTB4R,PTAFR,CYSLTR1,CES1,KLK1,MC2R,and PTGER3).Each patient group had a unique profile.Comparison between groups showed that 15 inflammation-related genes had significant expression change.Our results indicate that inflammation biomarkers can be used for diagnosis of TBI and evaluation of disease severity.This study was approved by the Institutional Review Board on December 18,2015(approval No.0078-12)and on June 9,2016(approval No.4093-16). | Yan Cheng Mandy Pereira Neha P.Raukar John L.Reagan Mathew Quesenberry Laura Goldberg Theodor Borgovan W Curt LaFrance Jr Mark Dooner Maria Deregibus Giovanni Camussi Bharat Ramratnam Peter Quesenberry | 2020 | Neural Regeneration Research2020，15，4： | 2 |
| 6 | Quantitative 1H magnetie resonance speetroscopy and MRI of Parkinson's disease显示文摘 | O'Neill J Sehuff N Marks WJ Jr | 2002 | Mov Disord2002，17，5： | 1 |
| 7 | Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia显示文摘 | Kung HN Marks JR Chi JT | 2011 | PLoS Genet2011，7，10： | 1 |
| 8 | Tropical cyclone kinematic structure retrieved from single-Doppler radar observations II: The GBVTD-simplex center finding algorithm显示文摘 | LEE W-C MARKS F D JR | 2000 | Mon WeaRev2000，128，6： | 1 |
| 9 | Fascial planes and compartment of posterior abdomen显示文摘 | Lei QF Marks SC Jr Touliopoulos P | 1990 | Clin Anat1990，3，1： | 1 |
| 10 | Multivariable prognostic models:issues in developing models,evaluating assumptions and adequacy,and measuring and reducing errors显示文摘 | Harrell FE Jr Lee KL Mark DB | 1996 | Stat Med1996，15，4： | 1 |
| 11 | Current management of gastrointestinal carcinoid tumors 显示文摘 | Woodside KJ Townsend CM Jr Mark Evers B | 2004 | J Gastrointest Srug2004，8，6： | 1 |
| 12 | Lidocaine hydrochloride显示文摘 | Mackley CL Marks JG Jr | 2003 | Am JContact Dermat2003，14，4： | 1 |
| 13 | A reaction rate method for ammonia and blood urea nitrogen utilizing a pentacyanonitrosyloferrate catalyzed Berthelot reaction显示文摘 | Weichselbaum T.E J.C. Hagerty H.B. Mark Jr | | 0，，： | 1 |
| 14 | Current management of gastrointestinal carcinoid tumors显示文摘 | Woodside KJ Townsend CM Jr Mark Evers B | 2004 | J Gas- trointest Surg2004，8，6： | 1 |
| 15 | BRCA1 expression is not directly responsive to estrogen显示文摘 | Huper G Vaughn JP | 1997 | Oncogene1997，14，1： | 1 |
| 16 | Anatomical characteristics of the iliopubic tract:implications for repair of inbuinal hernias显示文摘 | Marks SC Jr Qingfang Lei | 1992 | Clin Anat1992，5，4： | 1 |
| 17 | The iliopubic tract:an essential guide in teaching and performing groin hernia repairs显示文摘 | Gilroy A Marks SC Jr | 1996 | Contemp Surg1996，49，4： | 1 |
| 18 | Porcine circovirus 2 (PCV2) induces a procoagulant state in naturally infected swine and in cultured endothelial cells显示文摘 | Marks F S Reck J Jr Almeida L L | 2009 | Vet Microbiol2009，143，： | 1 |
| 19 | Localization of insulin receptor mRNA in rat brain by in situ hybridization 显示文摘 | Marks JL Porte D Jr Stahl WL | 1990 | Endo- crinology1990，127，： | 1 |
| 20 | Enhanced capillary blood flow in rapidly expanded random pattern flaps 显示文摘 | Marks MW Burney RE Mackenzie JR | 1986 | J Trauma1986，26，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员