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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020,2,1: | 26 |
| 2 | A Generic Workflow for the Data FAIRification Process显示文摘The FAIR guiding principles aim to enhance the Findability,Accessibility,Interoperability and Reusability of digital resources such as data,for both humans and machines.The process of making data FAIR(“FAIRification”)can be described in multiple steps.In this paper,we describe a generic step-by-step FAIRification workflow to be performed in a multidisciplinary team guided by FAIR data stewards.The FAIRification workflow should be applicable to any type of data and has been developed and used for“Bring Your Own Data”(BYOD)workshops,as well as for the FAIRification of e.g.,rare diseases resources.The steps are:1)identify the FAIRification objective,2)analyze data,3)analyze metadata,4)define semantic model for data(4a)and metadata(4b),5)make data(5a)and metadata(5b)linkable,6)host FAIR data,and 7)assess FAIR data.For each step we describe how the data are processed,what expertise is required,which procedures and tools can be used,and which FAIR principles they relate to. | Annika Jacobsen Rajaram Kaliyaperumal Luiz Olavo Bonino da Silva Santos Barend Mons Erik Schultes Marco Roos Mark Thompson | 2020 | Data Intelligence2020,2,1: | 5 |
| 3 | The“A”of FAIR-As Open as Possible,as Closed as Necessary显示文摘In order to provide responsible access to health data by reconciling benefits of data sharing with privacy rights and ethical and regulatory requirements,Findable,Accessible,Interoperable and Reusable(FAIR)metadata should be developed.According to the H2020 Program Guidelines on FAIR Data,data should be'as open as possible and as closed as necessary','open'in order to foster the reusability and to accelerate research,but at the same time they should be'closed'to safeguard the privacy of the subjects.Additional provisions on the protection of natural persons with regard to the processing of personal data have been endorsed by the European General Data Protection Regulation(GDPR),Reg(EU)2016/679,that came into force in May 2018.This work aims to solve accessibility problems related to the protection of personal data in the digital era and to achieve a responsible access to and responsible use of health data.We strongly suggest associating each data set with FAIR metadata describing both the type of data collected and the accessibility conditions by considering data protection obligations and ethical and regulatory requirements.Finally,an existing FAIR infrastructure component has been used as an example to explain how FAIR metadata could facilitate data sharing while ensuring protection of individuals. | Annalisa Landi Mark Thompson Viviana Giannuzzi Fedele Bonifazi Ignasi Labastida Luiz Olavo Bonino da Silva Santos Marco Roos | 2020 | Data Intelligence2020,2,1: | 4 |
| 4 | Enhanced Effect of Combining Human Cardiac Stem Cells and Bone Marrow Mesenchymal Stem Cells to Reduce Infarct Size and to Restore Cardiac Function After Myocardial Infarction显示文摘 | Adam R. Williams Konstantinos E. Hatzistergos Benjamin Addicott Fred McCall Decio Carvalho Viky Suncion Azorides R. Morales Jose Da Silva Mark A. Sussman Alan W. Heldman Joshua M. Hare | 2013 | Circulation2013,,2: | 2 |
| 5 | Circle of Willis:evaluation with spiral CT angiography,MR angiography,and conventional angiography显示文摘 | Marks MP Napel SA | 1995 | Radiology1995,195,2: | 1 |
| 6 | Circle of willis: Evaluation with spiral CT angiography, MR angiongraphy, and conventior, al angiography 显示文摘 | Katz DA Marks MP Napel SA | 1995 | Radiology1995,195,2: | 1 |
| 7 | Magnetic resonance imaging of the TMJ disc in asymptomatic volunteers显示文摘 | Ortendahl DA Mark AS | 1987 | J Oral Maxillofac Surg1987,45,: | 1 |
| 8 | B7-1(CD80)and B7-2(CD86) have complementary roles in mediating allergic pulmonary inflammation and airway hyperresponsiveness显示文摘 | Mark DA Donovan CE De Sanctis GT | 2000 | Am J Respir Cell Mol Biol2000,22,: | 1 |
| 9 | Circle of willis: evaluation with spiral CT angiography, MR angiography, and conventional angiography显示文摘 | Katz DA Marks MP Napel SA | 1995 | Radiology1995,195,2: | 1 |
| 10 | Human brain motion and cerebralspinal fluid circulation demonstrated with MR velocity imaging 显示文摘 | Feinberg DA Mark AS | 1987 | Radiology1987,16,27: | 1 |
| 11 | Characteristics of intractable seizures following meningitis and encephalitis 显示文摘 | Marks DA Kim J Spencer DD | 1992 | Neurology1992,42,8: | 1 |
| 12 | Amyloid betapeptide impairs ion-motive ATPase activities:evidence for a role in loss of neuronal Ca21 homeostasis and cell death显示文摘 | Mark RJ Hensley K Butterfield DA | 1995 | J Neurosci1995,15,: | 1 |
| 13 | Palliative care for patients with Huntington's disease #201显示文摘 | Marks S Hung S Rosielle DA | 2011 | J Palhat Med2011,14,5: | 1 |
| 14 | Adenoma detection rate and risk of colorectal cancer and death显示文摘 | Corley DA Jensen CD Marks AR | 2014 | N Engl J Med2014,370,14: | 1 |
| 15 | Human brain motion and cerebralspinal fluid circulation demonstrated with MR velocity imaging显示文摘 | Feinberg DA Mark AS | 1987 | Radiology1987,163,: | 1 |
| 16 | Strategies for the investi- gation and control of process- related impurities in drug sub- stances显示文摘 | MARK DA PAUL KO BERNARD AO | 2007 | Adv Drug Del Rev2007,59,1: | 1 |
| 17 | Comparison and correlation of surface and sphenoidal electrodes with simultaneous intracranial recording: an interictal study 显示文摘 | Katz A Booke J | 1992 | EEG Clin Neurophysiol1992,82,: | 1 |
| 18 | Both CD80 and CD86 co-stimulatory molecules regulate allergic pulmonary inflammation.显示文摘 | Mark DA | | 0,,: | 1 |
| 19 | Circle of willis: Evaluation with spiral CT angiography, MR angiography, and conventional angiography 显示文摘 | Katz DA Marks MP Napel SA | 1995 | Radiology1995,195,: | 1 |
| 20 | 查看详情显示文摘 | Mark DA | | 0,,: | 1 |