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| 1 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 2 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 3 | Natural course of functional dyspepsia after Helicobacter pylori eradication:a seven-year survey显示文摘 | Di Mario F Stefani N BòN D | 2005 | Dig Dis Sci2005，50，12： | 1 |
| 4 | Monte Carlo simulation as a tool to predict blasting fragmentation based on the Kuz-Ram model显示文摘 | MARIO A M FRANCESCO F | 2006 | Computers 85 Geosciences2006，32，： | 1 |
| 5 | Blind Frequency-offset estimation for OFDM/OQAM systems显示文摘 | Tilde F Mario T | 2007 | IEEE Trans on Signal Pro- cessing2007，55，5： | 1 |
| 6 | Salpingectomy and the risk of ovarian,fallopian tube,and peritoneal cancers in women with a BRCA1 or RCA2 mutation显示文摘 | Amy F Mario B | 2006 | JAMA2006，296，： | 1 |
| 7 | Label-free electroehemical detection of protein based on a ferrocene-bearing cationic polythiophene and aptamer显示文摘 | Fabien L F Hoang A H Mario L | 2006 | Anal Chem2006，，78： | 1 |
| 8 | Physiologic lesion assessment during percutaneous coronary intervention 显示文摘 | Melikian N Del Furia F Di Mario C | 2010 | Cardiol Clin2010，28，1： | 1 |
| 9 | Double recurrent interaction V1-V2-V4 based neural architecture for color natural scene boundary detection and surface perception显示文摘 | Díaz-Pernas F J Mario M Z Míriam A R | 2014 | Applied Soft Computing2014，21，： | 1 |
| 10 | Bovine lacto ferrin for Helicobacter pylori eradication: an open, randomized, muhicentre study显示文摘 | DI MARIO F ARAGONA G DAL BO N | 2006 | Aliment Pharmacol Ther2006，23，8： | 1 |
| 11 | Non-invasive tests in gastricdiseases显示文摘 | Di Mario F Cavallaro LG | 2008 | Dig Liver Dis2008，40，7： | 1 |
| 12 | The long-term clinical outcome of elderly patients with Helicobacter pylori-associated pep- tic ulcer disease显示文摘 | Pilotto A Franceschi M Di Mario F | 1998 | Gerontol1998，44，3： | 1 |
| 13 | Immature platelet fraction (IPF) in hospitalized patients with neutrophilia and suspected bacterial infection显示文摘 | Di Mario A Garzia M Leone F | 2009 | J Infect2009，59，3： | 1 |
| 14 | MTT colorimetric for testing macrophage cytotoxic activity in vitro 显示文摘 | Mario F Fornasiero MC Isetta AM | 1990 | JIM1990，131，6： | 1 |
| 15 | ‘Rescue' therapies for the management of Helicobacter pylori infection显示文摘 | Di Mario F Cavallaro LG Scarpignato C | 2006 | Dig Dis2006，24，12： | 1 |
| 16 | Aerothermodynamic study of UHTC-based thermal protection systems显示文摘 | RAFFAELE S MARIO S F DIEGO P | 2005 | Aerosp Sci Technol2005，9，： | 1 |
| 17 | Physiologic lesion asessment during percutaneous coronary intervention显示文摘 | Melikian N Del Furia F Di Mario C | 2010 | Cardiol Clin2010，28，1： | 1 |
| 18 | The long term outcome of gastric non-invasive neoplasia 显示文摘 | Rugge M Cassaro M Di Mario F | 2003 | Gut2003，52，8： | 1 |
| 19 | Intrarenal hemo- dynamic and oxidative stress in patients with obstructive sleep apnea syndrome显示文摘 | SARDO L PALANGE P DI MARIO F | 2015 | Sleep Breath2015，19，4： | 1 |
| 20 | High-resolution CT in silicosis correlation with radiographic findings and functional impairment显示文摘 | VINICIUS C S A GERMANIA A P MARIO T F | 2005 | J Comput Assist Tomogr2005，29，： | 1 |
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