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| 1 | Incidence of hepatocellular carcinoma in patients with chronic liver disease due to hepatitis B or C and coinfected with the human immunodeficiency virus:a retrospective cohort study显示文摘AIM To assess the incidence of hepatocellular carcinoma(HCC) in chronic liver disease due to hepatitis B virus(HBV) or hepatitis C virus(HCV) coinfected with human immunodeficiency virus(HIV).METHODS A retrospective cohort study was performed, including patients with chronic liver disease due to HBV or HCV, with and without HIV coinfection. Patients were selected in the largest tertiary public hospital complex in southern Brazil between January 2007 and June 2014. We assessed demographic and clinical data, including lifestyle habits such as illicit drug use or alcohol abuse, in addition to frequency and reasons for hospital admissions via medical records review.RESULTS Of 804 patients were included(399 with HIV coinfection and 405 monoinfected with HBV or HCV). Coinfected patients were younger(36.7 ± 10 vs 46.3 ± 12.5, P < 0.001). Liver cirrhosis was observed in 31.3% of HIV-negative patients and in 16.5% of coinfected(P < 0.001). HCC was diagnosed in 36 patients(10 HIV coinfected and 26 monoinfected). The incidence density of HCC in coinfected and monoinfected patients was 0.25 and 0.72 cases per 100 patient-years(95%CI: 0.12-0.46 vs 0.47-1.05)(long-rank P = 0.002), respectively. The ratio for the HCC incidence rate was 2.98 for HIV-negative. However, when adjusting for age or when only cirrhotic are analyzed, the absence of HIV lost statistical significance for the development of HCC. CONCLUSION In this study, the presence of HIV coinfection in chronic liver disease due to HBV or HCV showed no relation to the increase of HCC incidence. | Patrícia dos Santos Marcon Cristiane Valle Tovo Dimas Alexandre Kliemann Patrícia Fisch Angelo Alves de Mattos | 2018 | World Journal of Gastroenterology2018，24，5： | 6 |
| 2 | Endoscopic diagnosis and treatment of early esophageal squamous neoplasia显示文摘Esophageal cancer is one of the leading causes of cancer-related death and is associated with high morbidity and mortality.It carries a poor prognosis as more than half of patients present with advanced and unresectable disease.One contributing factor is the increased risk of lymph node metastases at early stages of disease.As such,it is essential to detect squamous cell neoplasia (SCN) at an early stage.In order to risk stratify lesions,endoscopists must be able to perform image enhanced endoscopy including magnification and Lugol's chromoendoscopy.The assessment of both the horizontal extent and depth of any lesion is also of utmost importance prior to treatment.Endoscopic mucosal resection and submucosal dissection remain the standard of care with literature supportive their respective use.Radiofrequency ablation and other endoscopic treatments are currently available although should not be considered first line at this time.Our objective is to review the current options for the endoscopic diagnosis and treatment of esophageal SCN. | Yuto Shimamura Takashi Ikeya Norman Marcon Jeffrey D Mosko | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 5 |
| 3 | Effect of pH,temperature and heating time on the formation of furan in sugar–glycine model systems显示文摘Furan(C4H4O)has been classified as a possible animal and human carcinogen by many international agencies.The formation of furan in three sugar–glycine models using glucose,fructose,and sucrose was investigated using headspace gas chromatography mass spectrometry method(HSGC–MS)with various dual combinations of three important heat processing conditions,i.e.pH,temperature,and heating time.Results indicated that furan levels from sugar–glycine model systems during the thermal processing can be attributed to selective sugar types,pH,temperature,and heating time.In glucose–glycine and fructose–glycine system,the lowest furan level was detected in acid condition but in sucrose–glycine system furan formed significantly lower(P<0.05)in acidic conditions the lowest furan level was found in alkaline conditions.The furan levels were observed to increase with heating time in all three model systems.Furthermore,less furan was generated in non-reducing sugar system(sucrose)than in reducing sugar system(glucose and fructose).Therefore,they demonstrate the possibility of limiting the formation of furan in heat processed foods by both the careful selection of carbohydrates(i.e.non-reducing sugars and reducing sugars)ingredients and appropriate processing conditions.©2013 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Shaoping Nie Jungen Huang Jielun Hu Yanan Zhang Sunan Wang Chang Li Massimo Marcone Mingyong Xie | 2013 | Food Science and Human Wellness2013，2，2： | 4 |
| 4 | Development and Optimization of an Alternative Methodology for Detection of Milk Adulteration by Water显示文摘 | Wesley William Gongalves Nascimento Marcone Augusto Leal de Oliveira1 Marcone Augusto Leal de Oliveira Marco Antonio Moreira Furtado Virgilio de Carvalho dos Anjos Maria Jose Valenzuela Bell | 2013 | Journal of Food Science and Engineering2013，3，7： | 2 |
| 5 | Objective and subjective evaluation of the acoustic comfort in classrooms显示文摘 | Paulo Henrique Trombetta Zannin Carolina Reich Marcon | 2007 | Applied Ergonomics2007，，38： | 1 |
| 6 | Milk - coagulating enzymes of tuna fish waste as a rennet substitute 显示文摘 | Tavares J F Baptista J A Marcone M F | 1997 | International Journal of Food Sciences and Nutrition1997，48，3： | 1 |
| 7 | The value of fluorescencetechniques in gastrointestinal endoscopy:better than theendoscopy's eye?I:European experience显示文摘 | Marcon NE Wilson BC | 1998 | Endoscopy1998，30，4： | 1 |
| 8 | Optimiza- tion of microwave-assisted extraction of phenolics from po- tato and its downstream waste using orthogonal array de- sign 显示文摘 | WU T YAN J LIU R H Marcone M F | 2012 | Food Chemistry2012，133，4： | 1 |
| 9 | Hydrophobic protein synthesized in the pod endocarp adheres to the seed surface显示文摘 | Marcone M F | 1999 | Ital J Food Sci1999，11，： | 1 |
| 10 | Serum levels of proinflammatory cytokines in painful knee osteoarthritis and sensitization显示文摘 | Imamura M Ezquerro F Marcon Alfieri F | 2015 | Int J Inflam2015，32，979： | 1 |
| 11 | Fast PDE approach to surface reconstruction from large cloud of points 显示文摘 | MARCON M PICCARRETA L SARTI A | 2008 | Computer Vision and Image Understanding2008，112，3： | 1 |
| 12 | Photodynamic therapy in the esophagus 显示文摘 | Tang S Marcon N | 2004 | Photodiag Photodyn Ther2004，1，： | 1 |
| 13 | Relationship of the internal jugular vein to the common carotid artery:implications for ultrasound-guided vascular access显示文摘 | Maecken T Marcon C Bomas C | 2011 | Eur J Anaesthesiol2011，28，5： | 1 |
| 14 | Measures of the geographic concentration of industries: improving distance based methods 显示文摘 | Marcon E and Puech F | 2010 | Journal of Economic Geography2010，，10： | 1 |
| 15 | Consensus report of the 2nd International Conference on Double Balloon Endoscopy显示文摘 | J. Pohl J. Blancas D. Cave K. Choi M. Delvaux C. Ell G. Gay M. Jacobs N. Marcon T. Matsui A. May C. Mulder M. Pennazio E. Perez-Cuadrado K. Sugano P. Vilmann H. Yamamoto T. Yano J. Zhong | 2008 | Endoscopy2008，，02： | 1 |
| 16 | Evaluating the geographic concentration of in- dustries using distance-based methods显示文摘 | Marcon E Puech F | 2003 | Journal of Economic Ge- ography2003，3，4： | 1 |
| 17 | Evaluating the geographic concentration of industries using distance-based methods显示文摘 | Puechf | 2003 | Journalof Economic Geography2003，，3： | 1 |
| 18 | A prospective, randomiced, controlled trial of covered expandable metal stents in the palliatian of malignant esophageal obstruction at the gastroesophageal junction 显示文摘 | VAKIL N MORRIS Al MARCON N | 2001 | Am J Gastroenteral2001，96，： | 1 |
| 19 | Determination of the geographical origin of Brazilian wines by isotope and mineral analysis显示文摘 | Durra S V Adami L Marcon A R | 2011 | Analytical and Bioanalytical Chemistry2011，401，5： | 1 |
| 20 | Recurrence ofcomeal stromal dystrophies after penetrating keratoplasty显示文摘 | Marcon AS Cohen EJ Rapuano CJ Laibson PR | 2003 | Comea2003，，： | 1 |
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