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| 1 | Association between Helicobacterpylori, Epstein-Barr virus, human papillomavirus and gastric adenocarcinomas显示文摘AIM To correlate Helicobacter pylori(H. pylori), Epstein-Barr virus(EBV) and human papillomavirus(HPV) with gastric cancer(GC) cases in Pará State, Brazil.METHODS Tissue samples were obtained from 302 gastric adenocarcinomas. A rapid urease test was used to detect the presence of H. pylori, and the presence of the cagA gene in the HP-positive samples was confirmed by PCR. An RNA in situ hybridization test designed to complement Eber1 RNA was used to detect the presence of EBV in the samples, and the L1 region of HPV was detected using nested PCR. Positive HPV samples were genotyped and analyzed for E6 and E7 viral gene expression. Infections were also correlated with the clinical and pathological characteristics of the patients.RESULTS The majority of the 302 samples analyzed were obtained from men(65%) aged 55 years or older(67%) and were classified as the intestinal subtype(55%). All three pathogens were found in the samples analyzed in the present study(H. pylori : 87%, EBV: 20%, HPV: 3%). Overall, 78% of the H. pylori-positive(H. pylori+) samples were cag A +(H. pylori-cag A+), and there was an association between the cytotoxic product of this gene and EBV. Coinfections of H. pylori-cagA+ and EBV were correlated with the most advanced tumor stages. Although only 20% of the tumors were positive for EBV, infection with this virus was associated with distant metastasis. Only the HPV 16 and 18 strains were found in the samples, although no expression of the E6 and E7 oncoproteins was detected. The fundus of the stomach was the region least affected by the pathogens.CONCLUSION HPV was not involved in gastric tumorigenesis. Prophylactic and therapeutic measures against H. pylori and EBV may prevent the development of GC, especially the more aggressive forms. | Carolina Rosal Teixeira de Souza Marcelli Carolini Alves Almeida Andre Salim Khayat Emerson Lucena da Silva Paulo Cardoso Soares Luiz Claudio Chaves Rommel Mario Rodriguez Burbano | 2018 | World Journal of Gastroenterology2018，24，43： | 6 |
| 2 | The HEPD particle detector of the CSES satellite mission for investigating seismo-associated perturbations of the Van Allen belts显示文摘CSES(China Seismo-Electromagnetic Satellite) is a mission developed by CNSA(Chinese National Space Administration) and ASI(Italian Space Agency), to investigate the near-Earth electromagnetic, plasma and particle environment, for studying the seismo-associated disturbances in the ionosphere-magnetosphere transition zone. The anthropogenic and electromagnetic noise,as well as the natural non-seismic electromagnetic emissions is mainly due to tropospheric activity. In particular, the mission aims to confirming the existence of possible temporal correlations between the occurrence of earthquakes for medium and strong magnitude and the observation in space of electromagnetic perturbations, plasma variations and precipitation of bursts with highenergy charged particles from the inner Van Allen belt. In this framework, the high energy particle detector(HEPD) of the CSES mission has been developed by the Italian LIMADOU Collaboration. HEPD is an advanced detector based on a tower of scintillators and a silicon tracker that provides good energy and angular resolution and a wide angular acceptance, for electrons of 3–100 Me V, protons of 30–200 Me V and light nuclei up to the oxygen. CSES satellite has been launched on February 2^(nd), 2018 from the Jiuquan Satellite Launch Center(China). | AMBROSI Giovanni BARTOCCI Simona BASARA Laurent BATTISTON Roberto BURGER William J. CARFORA Luca CASTELLINI Guido CIPOLLONE Piero CONTI Livio CONTIN Andrea DE DONATO Cinzia DE SANTIS Cristian FOLLEGA Francesco M. GUANDALINI Cristina IONICA Maria IUPPA Roberto LAURENTI Giuliano LAZZIZZERA Ignazio LOLLI Mauro MANEA Christian MARCELLI Laura MASCIANTONIO Giuseppe MERGE Matteo OSTERIA Giuseppe PACINI Lorenzo PALMA Francesco PALMONARI Federico PANICO Beatrice PATRIZII Laura PERFETTO Francesco PICOZZA Piergiorgio POZZATO Michele PUEL Matteo RASHEVSKAYA Irina RICCI Ester RICCI Marco RICCIARINI Sergio Bruno SCOTTI Valentina SOTGIU Alessando SPARVOLI Roberta SPATARO Bruno VITALE Vincenzo | 2018 | Science China(Technological Sciences)2018，61，5： | 6 |
| 3 | Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCap显示文摘 | Marcelli M Cunningham GR Haidacher SJ | | 0，，： | 2 |
| 4 | Signaling pathway activated during apoptosis of the proSTATe cancer cell line LNCaP: overexpression of caspase-7 as a new gene therapy strategy for proSTATe cancer显示文摘 | Marcelli M Cunningham G R Walkup M | 1999 | Cancer Res1999，59，2： | 1 |
| 5 | Use of the INNO LiPA Rif.TB for detection of Mycobacterium tuberculosis DNA directly in clinical specimens and for simultaneous determination of rifampin susceptibility显示文摘 | E. Tortoli F. Marcelli | 2007 | European Journal of Clinical Microbiology & Infectious Diseases2007，，1： | 1 |
| 6 | Prevalence of vertebral fractures in French women older than 75 years from the EPIDOS study显示文摘 | Grados F Marcelli C Dargent-Molina P | 2004 | Bone2004，34，： | 1 |
| 7 | Cardiovascular disease in chronic renal failure: The challenge continues显示文摘 | Locatelli F Marcelli D Conte F | 2000 | Nephrol Dial Transplant2000，15，： | 1 |
| 8 | Management of endometriosis of the urinary tract显示文摘 | Collinet P Marcelli F Villers A | | 0，，： | 1 |
| 9 | Asymmetric Organocatalytic Henry Reaction显示文摘 | Marcelli T Haas R | 2006 | Angew Chem Int Ed2006，45，： | 1 |
| 10 | Parathyroidectomy in patients on renal replacement therapy: an epidemiologic study显示文摘 | Malberti F Marcelli D Conte F | 2001 | J Am Soc Nephrol2001，12，6： | 1 |
| 11 | Trigeminal stimulation elicits a peripheral vestibular imbalance in migraine patients显示文摘 | Marano E Marcelli V Di Stasio E | 2005 | Headache2005，45，4： | 1 |
| 12 | Asymmetric organocatalytic Henry reaction 显示文摘 | T Marcelli R N S V Haas H Hiemstra | 2006 | Angew Chem Int Ed2006，45，： | 1 |
| 13 | Hergulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of Caspase-7 and is potentiated by impairment of protein kinase C alpha activity显示文摘 | Le XF Marcelli M McWatters A | | 0，，： | 1 |
| 14 | Does spinal morphology influence the occurrence of low back pain? A retrospective clinical, anthropometric, and radiological study 显示文摘 | Gautier J Morillon P Marcelli C | 1999 | Rev Rhum Engl Ed1999，66，： | 1 |
| 15 | Emerging roles of RB family: new defense mechanisms against tumor progression 显示文摘 | Indovina P Marcelli E Casini N | 2013 | J Cell Physiol2013，228，3： | 1 |
| 16 | Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma显示文摘 | Bataille R Chappard D Marcelli C | 1991 | J Clin Invest1991，88，62： | 1 |
| 17 | Molecular determinants of sexual differentiation显示文摘 | J. S. Wiener M. Marcelli D. J. Lamb | 1996 | World Journal of Urology1996，，5： | 1 |
| 18 | Induction of apoptosis in BPH stromal cells by adenoviral-mediated over expression of caspase-7显示文摘 | Shao TC Li X | 2000 | J Urol2000，164，2： | 1 |
| 19 | Survival and development of cardiovascular disease by modality of treatment in patients with endstage renal disease显示文摘 | Locatelli F Marcelli D Conte F | 2001 | J Am Soc Nephrol2001，12，： | 1 |
| 20 | Where are the niches? Dynamic fitness sharing 显示文摘 | CIOPPA A D STEFANO C D MARCELLI A | 2007 | IEEE Transactions on Evolutionary Computation2007，11，4： | 1 |
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