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| 1 | Free-breathing radial volumetric interpolated breathhold examination vs breath-hold cartesian volumetric interpolated breath-hold examination magnetic resonance imaging of the liver at 1.5T显示文摘AIM: To compare breath-hold cartesian volumetric interpolated breath-hold examination(cVIBE) and freebreathing radial VIBE(rVIBE) and determine whether rVIBE could replace cVIBE in routine liver magnetic resonance imaging(MRI).METHODS: In this prospective study, 15 consecutive patients scheduled for routine MRI of the abdomen underwent pre- and post-contrast breath-hold cVIBE imaging(19 s acquisition time) and free-breathing rVIBE imaging(111 s acquisition time) on a 1.5T Siemens scanner. Three radiologists with 2, 4, and 8 years post-fellowship experience in abdominal imaging evaluated all images. The radiologists were blinded to the sequence types, which were presented in a random order for each patient. For each sequence, the radiologists scored the cVIBE and rVIBE images for liver edge sharpness, hepatic vessel clarity, presence of artifacts, lesion conspicuity, fat saturation, and overall image quality using a five-point scale. RESULTS: Compared to rVIBE, cVIBE yielded significantly(P < 0.001) higher scores for liver edge sharpness(mean score, 3.87 vs 3.37), hepatic-vessel clarity(3.71 vs 3.18), artifacts(3.74 vs 3.06), lesion conspicuity(3.81 vs 3.2), and overall image quality(3.91 vs 3.24). cVIBE and rVIBE did not significantly differ in quality of fat saturation(4.12 vs 4.03, P = 0.17). The inter-observer variability with respect to differences between rVIBE and cVIBE scores was close to zero compared to random error and inter-patient variation. Quality of rVIBE images was rated as acceptable for all parameters. CONCLUSION: rVIBE cannot replace cVIBE in routine liver MRI. At 1.5T, free-breathing rVIBE yields acceptable, although slightly inferior image quality compared to breath-hold cVIBE. | Sireesha Yedururi HyunSeon C Kang Wei Wei Nicolaus A Wagner-Bartak Leonardo P Marcal R Jason Stafford Brandy J Willis Janio Szklaruk | 2016 | World Journal of Radiology2016，8，7： | 9 |
| 2 | Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy显示文摘AIM To detect hyper-conserved regions in the hepatitis B virus(HBV) X gene(HBX) 5' region that could be candidates for gene therapy.METHODS The study included 27 chronic hepatitis B treatmentnaive patients in various clinical stages(from chronic infection to cirrhosis and hepatocellular carcinoma, both HBeA g-negative and HBeA g-positive), and infected with HBV genotypes A-F and H. In a serum sample from each patient with viremia > 3.5 log IU/m L, the HBX 5' end region [nucleotide(nt) 1255-1611] was PCRamplified and submitted to next-generation sequencing(NGS). We assessed genotype variants by phylogenetic analysis, and evaluated conservation of this region by calculating the information content of each nucleotide position in a multiple alignment of all unique sequences(haplotypes) obtained by NGS. Conservation at the HBx protein amino acid(aa) level was also analyzed.RESULTS NGS yielded 1333069 sequences from the 27 samples, with a median of 4578 sequences/sample(2487-9279, IQR 2817). In 14/27 patients(51.8%), phylogenetic analysis of viral nucleotide haplotypes showed a complex mixture of genotypic variants. Analysis of the information content in the haplotype multiple alignments detected 2 hyper-conserved nucleotide regions, one in the HBX upstream non-coding region(nt 1255-1286) and the other in the 5' end coding region(nt 1519-1603). This last region coded for a conserved amino acid region(aa 63-76) that partially overlaps a Kunitz-like domain.CONCLUSION Two hyper-conserved regions detected in the HBX 5' end may be of value for targeted gene therapy, regardless of the patients' clinical stage or HBV genotype. | Carolina González David Tabernero Maria Francesca Cortese Josep Gregori Rosario Casillas Mar Riveiro-Barciela Cristina Godoy Sara Sopena Ariadna Rando Marcal Yll Rosa Lopez-Martinez Josep Quer Rafael Esteban Maria Buti Francisco Rodríguez-Frías | 2018 | World Journal of Gastroenterology2018，24，19： | 6 |
| 3 | Sonohysterography: Principles, technique and role in diagnosis of endometrial pathology显示文摘Sonohysterography (SHG), which provides enhanced endometrial visualization during standard transvaginal ultrasonography, is a relatively safe procedure for the evaluation of endometrial pathology. It can be used to evaluate patients with abnormal vaginal bleeding or infertility. This modality offers real time imaging of the endometrium without exposure to ionizing radiation. SHG is typically used in patients for whom standard transvaginal ultrasonography does not show the endometrium well, show a potential abnormality for which further imaging is required, or in patients without endometrial pathology defined on routine transvaginal imaging but in whom there is a strong clinical suspicion of an abnormality. This article will discuss the utility of the sonohysterogram in evaluation of various endometrial pathologies. Imaging examples of these pathological entities will be illustrated as well. | Thomas Yang Amit Pandya Leonardo Marcal Ronald O Bude Joel F Platt Deepak G Bedi Khaled M Elsayes | 2013 | World Journal of Radiology2013，5，3： | 5 |
| 4 | Intraoperative abdominal ultrasound in oncologic imaging显示文摘Significant advances in ultrasound technology have created new opportunities for its use in oncologic imaging. The advent of new transducers with focal beam technology and higher frequency has solidified the role of intraoperative sonography (IOUS) as an invaluable imaging modality in oncologic surgery of the liver, kidneys and pancreas. The ability to detect and characterize small lesions and the precise intraoperative localization of such tumors is essential for adequate surgical planning in segmental or lobar hepatic resections, metastasectomy, nephron-sparing surgery, and partial pancreatectomy. Also, diagnostic characterization of small equivocal lesions deemed indeterminate by conventional preoperative imaging such as multidetector computed tomography or magnetic resonance imaging, has become an important application of IOUS. This article will review the current applications of IOUS in the liver, kidneys and pancreas. | Leonardo P Marcal Madhavi Patnana Priya Bhosale Deepak G Bedi | 2013 | World Journal of Radiology2013，5，3： | 3 |
| 5 | Imaging of pancreatic ductal adenocarcinoma: State of the art显示文摘Significant advances in imaging technology have changed the management of pancreatic cancer. In computed tomography (CT), this has included development of multidetector row, rapid, thin-section imaging that has also facilitated the advent of advanced reconstructions, which in turn has offered new perspectives from which to evaluate this disease. In magnetic resonance imaging, advances including higher field strengths, thin-section volumetric acquisitions, diffusion weighted imaging, and liver specific contrast agents have also resulted in new tools for diagnosis and staging. Endoscopic ultrasound has resulted in the ability to provide high-resolution imaging rivaling intraoperative ultrasound, along with the ability to biopsy via real time imaging suspected pancreatic lesions. Positron emission tomography with CT, while still evolving in its role, provides whole body staging as well as the unique imaging characteristic of metabolic activity to aid disease management. This article will review these modalities in the diagnosis and staging of pancreatic cancer. | Eric Peter Tamm Priya Ranjit Bhosale Raghu Vikram Leonardo Pimentel de Almeida Marcal Aparna Balachandran | 2013 | World Journal of Radiology2013，5，3： | 3 |
| 6 | Chitosan-van- comysin composite biomaterial as a laser activated surgical adhesive with regional antimicrobial activity显示文摘 | Foster LJ Thomson K Marcal H | 2010 | Biomacro- molecules2010，11，12： | 1 |
| 7 | The effect of mesenchymal stem cell conditioned media on corneal stromal fibroblast wound healing activities显示文摘 | Watson S L Marcal H Sarris M | | 0，，08： | 1 |
| 8 | Substrate and dioxygen binding to the endospore coat laccase from Bacillus subtilis 显示文摘 | ENGUITA F J MARCAL D MARTINS L O | 2004 | J Biol Chem2004，279，23： | 1 |
| 9 | Small scale yielding near a crack in plane strain: A finite element analysis显示文摘 | N. Levy P. V. Marcal W. J. Ostergren J. R. Rice | 1971 | International Journal of Fracture Mechanics1971，，2： | 1 |
| 10 | Obesity inducedby high-fat diet promotes insulin resistance in the ovary 显示文摘 | Akamine E H Marcal A C Camporez J P | 2010 | JEndocrinol2010，206，1： | 1 |
| 11 | Elastic-plastic analysis of two dimensional stress systems by the finite element method 显示文摘 | Marcal P V King I P | 1967 | Int J Mech Sci1967，19，9： | 1 |
| 12 | The glass model: a strategy for quantifying global environmental security显示文摘 | Joseph Alcamo Marcal B Endejan Frank Kaspar | 2001 | Environmental Science & Policy2001，4，1： | 1 |
| 13 | A finite element formula- tion for problems of large strain and large displacement显示文摘 | Hibbitt H D Marcal P V Rice J R | 1970 | In- ternational Journal of Solids and Structure1970，，6： | 1 |
| 14 | T - helper cell type17/re - gulatoryT - cell immunoregulatory bal- ance in human radicular cysts and periapical granu - lo- mas 显示文摘 | Marcal J R Samuel R O Femandes D | 2010 | J Endod~2010，36，6： | 1 |
| 15 | 显示文摘 | Barbosa L V Marcal L Nassar E J | 2015 | Catal Today2015，246，： | 1 |
| 16 | A finite element formulation for problems of large strain and large displacement显示文摘 | Hibbit H D Marcal P V Rice J R | 1970 | Int J Solids Strut1970，6，： | 1 |
| 17 | Educating for ethics:business deans' perspectives显示文摘 | Evans F.J Marcal L.E | | 0，，03： | 1 |
| 18 | BioPEGylation of Polyhydroxybutyrate Promotes Nerve Cell Health and Migration显示文摘 | Rodman T H Chan Robert A Russell Helder Marcal | 2014 | Biomacromolecules2014，15，： | 1 |
| 19 | Blending Scrum practices and CMMI project management process areas显示文摘 | Marcal A S C Freitas B C C | 2008 | Innovations Syst Softw Eng2008，4，1： | 1 |
| 20 | Numberical thermo-mechanical model for the welding and subsequent loading of a fabricated structure显示文摘 | Hibbit H D Marcal P V A | 1973 | Comput Struct1973，13，9： | 1 |
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