|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Aerobic Oxidation of Benzyl Alcohol Catalyzed by Cu-Mn Mixed Oxides and 2,2,6,6-Tetramethyl-piperidyl-1-oxyl显示文摘异构的 Cu-Mn 混合了氧化物能调停由在中立状况下面的分子的氧的本甲基酒精的催化速度的选择氧化,并且是 recyclable。在超过 1 的 Cu 和 Mn 的摩尔比率的情况中,在 Cu-Mn 内的高度分散的 CuO 混合了氧化物为在催化氧化的好表演负责。给词调音:Cu-Mn 氧化物;2,2,6,6-tetramethyl-piperidyl-l-oxyl;氧气的氧化; | Yanchun Guo Junfeng Zhao Jinxia Xu Wei Wang Fengshou Tian Guanyu Yang Maoping Song | 2007 | Journal of Natural Gas Chemistry2007,16,2: | 6 |
| 2 | The HDAC3 enzymatic activity regulates skeletal muscle fuel metabolism显示文摘Histone deacetylase 3 (HDAC3) is a major HDAC, whose enzymatic activity is targeted by small molecule inhibitors for treating a variety of conditions. However, its enzymatic activity is largely dispensable for its function in embryonic development and hepatic lipid metabolism.HDAC3 plays a pivotal role in regulating muscle fuel metabolism and contractile function. Here, we address whether these muscular functions of HDAC3 require its enzymatic activity. By mutating the NCoR/SMRT corepressors in a knock - in mouse model named NS-DADm, we ablated the enzymatic activity of HDAC3 without affecting its protein levels. Compared to the control mice, skeletal muscles from NS-DADm mice showed lower force generation, enhanced fatigue resistance, enhanced fatty acid oxidation, reduced glucose uptake during exercise, upregulated expression of metabolic genes involved in branchedchain amino acids catabolism, and reduced muscle mass during aging, without changes in the muscle fiber-type composition or mitochondrial protein content. These muscular phenotypes are similar to those observed in the HDAC3-depleted skeletal muscles, which demonstrates that, unlike that in the liver or embryonic development, the metabolic function of HDAC3 in skeletal muscles requires its enzymatic activity. These results suggest that drugs specifically targeting HDAC3 enzyme activity could be developed and tested to modulate muscle energy metabolism and exercise performance. | Shiyan Song Yefei Wen Hui Tong Emanuele Loro Yingyun Gong Jidong Liu Sungguan Hong Lei Li Tejvir S.Khurana Maoping Chu Zheng Sun | 2019 | Journal of Molecular Cell Biology2019,11,2: | 3 |
| 3 | Cyclopalladated ferrocenylimines as efficient catalysts for homogeneous catalysis:A brief introduction to our preliminary achievements显示文摘Cyclopalladated ferrocenylimines as a novel kind of highly efficient palladium catalyst precursors, which are air-stable and easy to handle, have been successfully applied in a wide variety of catalytic reactions ranging from classical reactions, such as Heck, Suzuki, Sonogashira and Buchwald-Hartwig couplings, to cyanation, addition reactions of arylboronic acids, and coupling reactions involving terminal alkynes. The preliminary achievements regarding their applications to homogeneous catalysis are concisely described herein. | WU YangJie YANG Fan ZHANG JinLi CUI XiuLing GONG JunFang SONG MaoPing LI TieSheng | 2010 | Chinese Science Bulletin2010,55,25: | 2 |
| 4 | Targeted delivery of a STING agonist to brain tumors using bioengineered protein nanoparticles for enhanced immunotherapy显示文摘Immunotherapy is emerging as a powerful tool for combating many human diseases.However,the application of this life-saving treatment in serious brain diseases,including glioma,is greatly restricted.The major obstacle is the lack of effective technologies for transporting therapeutic agents across the blood-brain barrier(BBB)and achieving targeted delivery to specific cells once across the BBB.Ferritin,an iron storage protein,traverses the BBB via receptor-mediated transcytosis by binding to transferrin receptor 1(TfR1)overexpressed on BBB endothelial cells.Here,we developed bioengineered ferritin nanoparticles as drug delivery carriers that enable the targeted delivery of a small-molecule immunomodulator to achieve enhanced immunotherapeutic efficacy in an orthotopic glioma-bearing mouse model.We fused different glioma-targeting moieties on self-assembled ferritin nanoparticles via genetic engineering,and RGE fusion protein nanoparticles(RGE-HFn NPs)were identified as the best candidate.Furthermore,RGE-HFn NPs encapsulating a stimulator of interferon genes(STING)agonist(SR717@RGE-HFn NPs)maintained stable self-assembled structure and targeting properties even after traversing the BBB.In the glioma-bearing mouse model,SR717@RGE-HFn NPs elicited a potent local innate immune response in the tumor microenvironment,resulting in significant tumor growth inhibition and prolonged survival.Overall,this biomimetic brain delivery platform offers new opportunities to overcome the BBB and provides a promising approach for brain drug delivery and immunotherapy in patients with glioma. | Bin Wang Maoping Tang Ziwei Yuan Zhongyu Li Bin Hu Xin Bai Jinxian Chu Xiaoyang Xu Xue-Qing Zhang | 2022 | Bioactive Materials2022,7,10: | 2 |
| 5 | Characterization of TiO2-PVP nanocomposites prepared by the sol-gel method显示文摘 | ZHENG MAOPING JIN YANGPING GU MINGYUAN | 2000 | J Mater Sci lett2000,,19: | 1 |
| 6 | Mitochondria- targeted antioxidants protect against amy|old-beta toxicity in Alzheimer's disease neurons显示文摘 | Manczak M MaoP Calkins MJ | 2010 | Alzheimers Dis2010,20,2: | 1 |
| 7 | Effects of PVP on structure of TiO2 prepared by the sol-gel process 显示文摘 | Zheng Maoping Gu Mingyuan Jin Yanping | 2001 | Materials Science and Engineering B2001,87,: | 1 |
| 8 | Preparation, structure and properties of TiO2-PVP hybrid films 显示文摘 | Zheng Maoping Gu Mingyuan Jin Yanping | 2000 | Materials Science and Engineering B2000,77,1: | 1 |
| 9 | Preparation and characterization of silica-doped titania photocatalyst through sol-gel method显示文摘 | Cheng Ping Zheng Maoping Jin Yangping | 2003 | Materials Letters2003,57,20: | 1 |
| 10 | Effects of PVP on structure of TiO2 prepared by the sol-gel process 显示文摘 | Zheng Maoping Gu Mingyuan | 2001 | Mater Sci Eng2001,87,: | 1 |
| 11 | Characterization of TiO2-PVP nanocomposites prepared by the sol-gel method显示文摘 | Zheng Maoping Jin Yangping Gu Mingyuan | 2000 | J Mater Sci Lett2000,5,19: | 1 |
| 12 | Preparationg and characterizationg of silica-doped titania photocatalyst through sol-gel method显示文摘 | Maoping Zheng Yangping Jin | 2003 | Mater Letters2003,57,: | 1 |
| 13 | Preparation, structure and properties of TiO2-PVP hybrid films显示文摘 | Maoping Zheng Minyuan Gu Yanping Jin Guoliang Jin | 2000 | Materials Science & Engineering B2000,77,: | 1 |
| 14 | Preparation and characterization of silica-doped titania photo catalyst through Sol-Gel method显示文摘 | Ping Cheng Maoping Zheng Yanping Jin | 2003 | Materials Letters2003,57,: | 1 |
| 15 | Berberine-induced inhibition of adipocyte enhancer-binding protein 1 attenuates oxidized low-density lipoprotein accumulation and foam cell formation in phorbol 12-myristate 13-acetate-induced macrophages显示文摘 | Zhouqing Huang Fengquan Dong Sheng Li Maoping Chu Hao Zhou Zhongqiu Lu Weijian Huang | 2012 | European Journal of Pharmacology (-)2012,,1: | 1 |
| 16 | Preparation and Characterization of Silica-doped Titania Photocatalyst through Sol-gel Method显示文摘 | Cheng Ping Zheng Maoping Jin Yanping | 2003 | Material Letters2003,57,: | 1 |
| 17 | Preparation and characterization of silica-doped titania photocatalyst through sol–gel method显示文摘 | Ping Cheng Maoping Zheng Yanping Jin Qiang Huang Mingyuan Gu | 2002 | Materials Letters2002,,20: | 1 |
| 18 | Pr@aration and char- acterization of silica-doped titania photocatalyst through sol-gel method显示文摘 | Cheng Ping Zheng Maoping | 2003 | Mater Letters2003,57,: | 1 |
| 19 | Preparation and Characterization of Silica-doped Titania Photocatalyst through Sol-gel Method 显示文摘 | Ping Cheng Maoping Zheng Yanping Jin | 2003 | Materialz Letters2003,57,20: | 1 |
| 20 | reparation and characterization of silica-doped titania photocatalyst through solgel method显示文摘 | Cheng Ping Zheng Maoping Jin Yanping | 2003 | Materials Letters2003,,57: | 1 |