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| 1 | Late Mesozoic rifting and its deep dynamic mechanisms in the central Sulu orogenic belt: Records from Lingshan Island显示文摘The Lingshan Island scientific drill confirms that two episodes(Laiyang period and Qingshan period) of rifting developed in the central Sulu orogenic belt(SOB) in Late Mesozoic. With a set of methods including fieldwork, drilling, core logging, zircon U-Pb dating and whole rock geochemistry applied, the age, the depositional sequence and the deep dynamic mechanisms of rift evolution were unraveled. The stratigraphic sequence of the Laiyang-Qingshan Groups on Lingshan Island was composed of two different rifting sequences:(1) Laiyang Group(147–125 Ma), which consists of deep-water gravity flow deposits with interlayers of intermediate volcanic rocks;and(2) Lower Qingshan Group(125–119 Ma), which unconformably overlies the former sequence and contains subaerial volcanic deposits and terrestrial deposits. The tectonic environment changed during the evolution of these two episodes of rifting: the rift was in a NNW-SSE extensional environment in the Laiyang period and showed the typical passive rifting character that “lithospheric extension and rifting preceded volcanism”. The passive rifting period was ended by a short WNW-ESE compression at about 125 Ma. After that, the tectonic environment transferred to a strong NW-SE extensional environment and the rifting evolved into a volcanic arc basin in the Qingshan period. The igneous rocks are shoshonitic to high-K calc-alkaline trachyandesites to trachytes with a few intercalated lamprophyres and a rhyolite.The geochemical characteristics of the igneous rocks indicate that they are mantle-derived melts with a metasomatized mantle source and/or crustal contamination. In addition, an increased thinning of the lithosphere happened during the rifting episodes.The low-angle subduction of the Paleo-Pacific plate in the Jurassic weakened the thickened SOB lithospheric mantle. The rollback of the subducting plate started in late Jurassic to early Cretaceous, and the SOB lithospheric mantle was delaminated synchronously because of the gravity collapse. Thus, this caused passive rifting in the Laiyang period. Thereafter, the rollback and trench retreat of the high-angle subducting Paleo-Pacific plate would have achieved its climax, resulting in the strong regional extension. Passive rifting was ended by the crustal uplift caused by asthenospheric upwelling beneath the rift. The lower crust was heated by the upwelling asthenosphere and partially melted to form felsic melts, which were emplaced upwards and erupted explosively. The rift evolved into a volcanic arc basin in the Qingshan period and showed some characteristics of active rifting. Above all, a passive rifting in the Laiyang period and a volcanic arc basin in the Qingshan period developed successively in the Lingshan Island area(the central SOB). This records the transfer of the study area from the Paleo-Tethys tectonic domain to the circum-Pacific tectonic domain. The delamination of SOB lithospheric mantle and the upwelling of asthenospheric material were the deep dynamic mechanisms driving the development and evolution of two rift episodes. Additionally, the rift development was controlled remotely by the subduction of the Paleo-Pacific plate. | Tengfei ZHOU Yaoqi ZHOU Nina SФAGER Paul Martin HOLM Zhenkai ZHANG Jun WANG Zhao LIANG Hongyu MU Yanjun CHENG Feifei LIU Miao WANG Yue ZHANG Hui ZHANG Yangjian GU Shihui DONG Hanjie ZHAO Manjie LI Yang CHEN Yanzi LIU | 2022 | Science China Earth Sciences2022，65，9： | 3 |
| 2 | Facile Approach to Synthesize Gold Nanorod@Polyacrylic Acid/Calcium Phosphate Yolk–Shell Nanoparticles for Dual-Mode Imaging and pH/NIR-Responsive Drug Delivery显示文摘A facile strategy to fabricate gold nanorod@polyacrylic acid/calcium phosphate(Au NR@-PAA/Ca P) yolk–shell nanoparticles(NPs) composed with a PAA/Ca P shell and an Au NR yolk is reported. The asobtained Au NR@PAA/Ca P yolk–shell NPs possess ultrahigh doxorubicin(DOX) loading capability(1 mg DOX/mg NPs), superior photothermal conversion property(26%)and p H/near-infrared(NIR) dual-responsive drug delivery performance. The released DOX continuously increased due to the damage of the Ca P shell at low p H values. When the DOX-loaded Au NR@PAA/Ca P yolk–shell NPs wereexposed to NIR irradiation, a burst-like drug release occurs owing to the heat produced by the Au NRs. Furthermore,Au NR@PAA/Ca P yolk–shell NPs are successfully employed for synergic dual-mode X-ray computed tomography/photoacoustic imaging and chemo-photothermal cancer therapy. Therefore, this work brings new insights for the synthesis of multifunctional nanomaterials and extends theranostic applications. | Guilan Li Yidan Chen Lingyu Zhang Manjie Zhang Shengnan Li Lu Li Tingting Wang Chungang Wang | 2018 | Nano-Micro Letters2018，10，1： | 3 |
| 3 | Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma显示文摘BACKGROUND Hypoxia-inducible factor 1α(HIF-1α) is a gene that regulates tumor survival,neovascularization and invasion. Overexpression of HIF-1α correlates with poor prognosis in hepatocellular carcinoma(HCC). RO7070179 is a HIF-1α inhibitor that decreases HIF-1α mRNA and its downstream targets, it could be a potential treatment in HCC.AIM To evaluate safety and preliminary activity of RO7070179 in patients with previously treated HCC, with focus on a patient with prolonged response to RO7070179.METHODS In the preclinical study of RO7070179 in a HCC xenograft model, the mice wereseparated into 4 groups with each group received doses of 0, 3, 10 and 30 mg/kg for total 10 doses. HCC patients who failed at least one line of systemic treatment,received RO7070179 as a weekly infusion, each cycle is 6 wk. We evaluated the safety and HIF-1α mRNA levels of RO7070179.RESULTS Preclinical evaluation of RO7070179 in orthotopic HCC xenograft model showed no significant differences in HCC tumor weight between the 3 and 10 mg/kg groups. However, dose of 10 mg/kg of RO7070179, has shown 76% reduction of the amount of HIF-1α mRNA in HCC tissue. In the phase 1 b study of RO7070179 in previously treated HCC patients, 8 out of 9 were evaluable: 1 achieved PR and1 SD. The patient with PR responded after 2 cycles treatments, which has been maintained for 12 cycles. This patient also showed reduction in perfusion of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) after 1 cycle of treatment. After 1 cycle of treatment, both patients with PR and SD showed decrease in HIF-1α mRNA at the root of biopsies(each biopsy was divided into 2 specimens, the tip and the root).CONCLUSION RO7070179 can reduce HIF-1α mRNA level in HCC patients with SD or PR. It is well tolerated at 10 mg/kg, with transaminitis as the dose of increased toxicity.This study indicates that RO7070179 might benefit HCC patients, and an early signal for clinical benefit can potentially be predicted through changes in either m RNA level or DCE-MRI within 1 cycle of therapy. | Jennifer Wu Merly Contratto Krishna P Shanbhogue Gulam A Manji Bert H O'Neil Anne Noonan Robert Tudor Ray Lee | 2019 | World Journal of Clinical Oncology2019，10，3： | 2 |
| 4 | Impairments of neuroplasticity and cellular resilience in severe mood disorders: implications for the development of novel therapeutics显示文摘 | Manji HK Duman RS | 2001 | Psychopharmacol Bull2001，35，： | 1 |
| 5 | The effect of head position on the distribution of topical nasal medication using the Mucosal Atomization Device: a cadaver study显示文摘 | Habib AR Thamboo A Manji J | 2013 | Int Forum Allergy Rhinol2013，3，12： | 1 |
| 6 | New insights into BDNF function in depression and anxiety显示文摘 | MARTINOWICH K MANJI H LU B | 2007 | Nat Neurosci2007，1，9： | 1 |
| 7 | Timing of hyperoxic exposure during alveolarization influences damage mediated by leukotrienes显示文摘 | O′Kelly CJ Leung WI | 2001 | Am J Physiol Lung Cell Mol Physiol2001，281，4： | 1 |
| 8 | PKC, MAP kinases and the bcl-2 family of proteins as long-term targets for mood stabilizers显示文摘 | Manji HK Chen G | 2002 | Mol Psychiatry2002，7，1： | 1 |
| 9 | Acute pancreatitis as a model of sepsis 显示文摘 | Wilson PG Manji M Neoptolemos JP | 1998 | J Antimicrobial Chemotherapy1998，41，： | 1 |
| 10 | Signalling pathways in the brain: cellular transduction of mood stabilisation in the treatment of manic-depressive illness显示文摘 | Manji HK McNamara R Chen G | 1999 | Aust N Z J Psychiatry1999，33，： | 1 |
| 11 | Effect of Storage Temperature on Age Gelation of Ultra High Temperature Milk Processed by Direct and Indirect Heating Systems显示文摘 | MANJI B KAKUDA Y ARNOTT D R | 1986 | J Dairy Sci1986，69，： | 1 |
| 12 | The role of AMPA receptor modulation in the treatment of neuropsychiatric diseases显示文摘 | Zarate C A Manji H K | | 0，，01： | 1 |
| 13 | Baculovirus inhibitor of apoptosis functions at or upstream of the apoptotic suppressor p35 to prevent programmed cell death显示文摘 | Hozak R R LaCount D J Friesen P D | 1997 | J Virol1997，71，6： | 1 |
| 14 | Potential mechanisms of action of lamotrigine in the treatment of bipolar disorders显示文摘 | Ketter TA Manji HK Post RM | 2003 | J Clin Psychopharmacol2003，23，5： | 1 |
| 15 | Tooth mortality in an adult rural population in Kenya显示文摘 | Manji F Baelum V Fejerskov O | 1988 | J Dent Res1988，67，2： | 1 |
| 16 | Circumcision of the young infant in a developing country using the Plastibell 显示文摘 | Manji KP | 2000 | Ann Paediatr2000，20，2： | 1 |
| 17 | Penicillin resistance and serotype distribution of Streptococcus pneumoniae in nasopharyngeal carrier children under 5 years of age in Dar es Salaam, Tanzania显示文摘 | Sabrina J. Moyo Martin Steinbakk Said Aboud Namala Mkopi Mabula Kasubi Bjorn Blomberg Karim Manji Eligius F. Lyamuya Samuel Y. Maselle Nina Langeland | 2012 | Journal of Medical Microbiology (Pt )2012，，7： | 1 |
| 18 | Endotoxin reduces maximal oxygen consumption in hepatocytes independent of any hypoxic insult显示文摘 | Rosser DM Manji M Cooksley H | | 0，，： | 1 |
| 19 | Potential mechanisms of action of lamotrigine in the treatment of bipolar disorders 显示文摘 | KETTER TA MANJI HK POST RM | 2003 | J Clin Psychopharmacol2003，23，5： | 1 |
| 20 | The hypoxic ischaemie en- cephalopathy score in predicting neurodevelopmental outcomes among infants with birth asphyxia at the Muhimbili National Hospital,Dar- es-Salaam,Tanzania显示文摘 | Mwakyusa SD Manji KP Massawe AW | 2009 | J Trop Pediatr2009，55，1： | 1 |
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