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| 1 | Role of(~(18)F)2-fluoro-2-deoxyglucose positron emission tomography in upper gastrointestinal malignancies显示文摘The role of whole-body FDG [(~(18)F)2-fluoro-2-deoxy-glucose] positron emission tomography(PET)scan-ning as an imaging modality in the management of patients with malignancy has evolved enormously over the past two decades.FDG-PET has demonstrated signifi cant effi cacy in the staging,prognostication and detection of occult metastatic disease in malignancies of the gastrointestinal tract,in addition to assessment of the response to cytotoxic chemotherapy in a more timely manner than has traditionally been possible by more conventional imaging tools.The sensitivity and specif icity of FDG-PET for the detection and staging of malignancy depend not only on the site and size of the primary tumor and metastases,but also on histologi-cal cell type,reflecting underlying disparities in glucose metabolism.The metabolic response to neo-adjuvant chemotherapy or to chemo-radiotherapy in cancers of the gastro-esophageal junction or stomach has been demonstrated in several prospective studies to correlate signifi cantly with both the histological tumor response to treatment and with consequent improvements in overall survival.This may offer a future paradigm ofpersonalized treatment based on the PET response to chemotherapy.FDG-PET has been less successful in efforts to screen for and detect recurrent upper gastro-intestinal malignancies,and in the detection of low vol-ume metastatic peritoneal disease.Efforts to improve the accuracy of PET include the use of novel radiotrac-ers such as(~(18)F)FLT(3-deoxy-3-fluorothymidine)or 11C-choline,or fusion PET-CT with concurrent high-res-olution computed tomography.This review focuses on the role of FDG-PET scanning in staging and response assessment in malignancies of the upper gastrointesti-nal tract,specif ically gastric,esophageal and pancreas carcinoma. | Elizabeth C Smyth Manish A Shah | 2011 | World Journal of Gastroenterology2011，17，46： | 6 |
| 2 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 3 | Comparative effectiveness of adipose-derived mesenchymal stromal cells in the management of knee osteoarthritis:A meta-analysis显示文摘BACKGROUND Osteoarthritis(OA)is the most common joint disorder,is associated with an increasing socioeconomic impact owing to the ageing population.AIM To analyze and compare the efficacy and safety of bone-marrow-derived mesenchymal stromal cells(BM-MSCs)and adipose tissue-derived MSCs(AD-MSCs)in knee OA management from published randomized controlled trials(RCTs).METHODS Independent and duplicate electronic database searches were performed,including PubMed,EMBASE,Web of Science,and Cochrane Library,until August 2021 for RCTs that analyzed the efficacy and safety of AD-MSCs and BM-MSCs in the management of knee OA.The visual analog scale(VAS)score for pain,Western Ontario McMaster Universities Osteoarthritis Index(WOMAC),Lysholm score,Tegner score,magnetic resonance observation of cartilage repair tissue score,knee osteoarthritis outcome score(KOOS),and adverse events were analyzed.Analysis was performed on the R-platform using OpenMeta(Analyst)software.Twenty-one studies,involving 936 patients,were included.Only one study compared the two MSC sources without patient randomization;hence,the results of all included studies from both sources were pooled,and a comparative critical analysis was performed.RESULTS At six months,both AD-MSCs and BM-MSCs showed significant VAS improvement(P=0.015,P=0.012);this was inconsistent at 1 year for BM-MSCs(P<0.001,P=0.539),and AD-MSCs outperformed BM-MSCs compared to controls in measures such as WOMAC(P<0.001,P=0.541),Lysholm scores(P=0.006;P=0.933),and KOOS(P=0.002;P=0.012).BM-MSC-related procedures caused significant adverse events(P=0.003)compared to AD-MSCs(P=0.673).CONCLUSION Adipose tissue is superior to bone marrow because of its safety and consistent efficacy in improving pain and functional outcomes.Future trials are urgently warranted to validate our findings and reach a consensus on the ideal source of MSCs for managing knee OA. | Sathish Muthu Sandesh C Patil Naveen Jeyaraman Madhan Jeyaraman Prakash Gangadaran Ramya Lakshmi Rajendran Eun Jung Oh Manish Khanna Ho Yun Chung Byeong-Cheol Ahn | 2023 | World Journal of Orthopedics2023，14，1： | 2 |
| 4 | Investigation of Plasma Polymerized Benzene and Furan Thin Films for Application in Opto-electronie Devices显示文摘 | JOBANPUTRA Manish C DURSTOCK Michael F CLARSON Stephen J | 2003 | Journal of Applied Polymer Science2003，，87： | 1 |
| 5 | Arene ruthenium complexes incorporating immine/azine hybrid-chelating N- N' donor ligands: Synthetic, spectral, structural aspects and DFT studies 显示文摘 | Manish C Abhaya N Sahay | 2004 | Journal of Organometallic Chemistry2004，689，： | 1 |
| 6 | Optimal Design of Heat Exchangers:A Genetic Algorithm Framework显示文摘 | Yan Fu | 1999 | Industrial & Engineering Chemistry Research1999，38，2： | 1 |
| 7 | Cross-linked guar gum microspheres a viable approach for improved delivery of anticancer drugs for the treatment of colorectal cancer显示文摘 | Mohini C Manish K C Nitin K J | 2006 | AAPS Pharm Sci Tech2006，7，3： | 1 |
| 8 | Erosive wear of hardfaced Fe-Cr-C alloys at elevated temperature显示文摘 | Katsich C Badisch E Manish Roy | 2009 | Wear2009，267，11： | 1 |
| 9 | Creep behavior in near-nanostructured Al 5083 alloy显示文摘 | MANISH C H I ROY FARGHALLI A Mohamed | 2005 | Materials Science and Engineering A2005，41，： | 1 |
| 10 | Chemically derived graphene oxide: towards large-area thin-film electronics and optoelectronics 显示文摘 | GOKI E MANISH C | 2010 | Adv Mater2010，22，23： | 1 |
| 11 | Erosive wear of hardfaced Fe-Cr-C alloys at elevated temperature显示文摘 | KATSICHA C BADISCHA E MANISH R | 2009 | Wear2009，267，： | 1 |
| 12 | An alternative technique for implantation of a dual chamber pacemaker via a persistent left superior vena cava using a coronary sinus guiding catheter显示文摘 | Manish M Chris C Peter B | 2010 | J Cardiol Cases2010，2，： | 1 |
| 13 | A novel method to measure cleanliness in steel using ultrasonic e-scan image analysis显示文摘 | Pandely J C Manish RAJ ROY T K | 2008 | Metallurgical and Materials Transactions B2008，39，3： | 1 |
| 14 | Immunoadjuvant potential of Asparagus racemosus aqueous extract in experimental system显示文摘 | Manish Gautama Sham Diwanay b Sunil Gairola c Yojana Shinde Pralhad Patki c Bhushan Patwardhan | 2004 | Journal of Ethnopharmacology2004，91，： | 1 |
| 15 | A pulsedUWB receiver SoC for insect motion control 显示文摘 | DENIS C D PATRICK P M MANISH B | 2010 | IEEE Jof Solid-State Circuits2010，45，1： | 1 |
| 16 | Automatic target detection and tracking in forward-looking infrared image sequences using morphological connected operators 显示文摘 | Ulisses B N Manish C John G | 2004 | Journal of Electronic Imaging2004，13，4： | 1 |
| 17 | The Ilizarov method in infected nonunion of fractures显示文摘 | LALIT M MANISH C JASHAN V | 2000 | Injury Int J Care Injured2000，31，： | 1 |
| 18 | Acute colonic emergencies显示文摘 | Katharine EB Manish C Tom DC | | 0，，： | 1 |
| 19 | Spin-Dependent Tunneling Junctions with A1N and AION Barri- ers显示文摘 | Manish Sharma Janice H Nickel Thomas C Anthony | 2000 | Appl Phys Lett2000，，77： | 1 |
| 20 | Helicity-induced nation polymers built with two-layered Cd(II) coordi- different kinked diearboxylates and an organodiimidazole显示文摘 | SUBHADIP Neogi MANISH K Sharma MADHAB C Das | 2009 | Polyhedron2009，28，18： | 1 |
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