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| 1 | Prospective evaluation of small bowel preparation with bisacodyl and sodium phosphate for capsule endoscopy显示文摘AIM: To determine the effect of Prepacol?, a com- bination of sodium phosphate and bisacodyl, on transit and quality of capsule endoscopy (CE). METHODS: Fivety two consecutive patients were included in this prospective study. CE was performed following a 12 h fasting period. Twenty six patients were randomized for additional preparation with Prepacol?. The quality of CE was assessed separately for the proximal and the distal small bowel by 3 experienced endoscopists on the basis of a graduation which was initially developed with 20 previous CE. RESULTS: Preparation with Prepacol? accelerated small bowel transit time (262 ± 55 min vs 287 ± 97 min), but had no effect on the quality of CE. Visibility was significantly reduced in the distal compared to the proximal small bowel. CONCLUSION: The significantly reduced visibility of CE in the distal small bowel allocates the need for a good preparation. Since Prepacol? has no beneficial effect on CE the modality of preparation and the ideal time of application remains unclear. Further standardized examinations are necessary to identify sufficient preparation procedures and to determine the impact of the volume of the preparation solution. | Andreas Franke Frank Hummel Phillip Knebel Christoph Antoni Ulrich Bcker Manfred V Singer Matthias Lhr | 2008 | World Journal of Gastroenterology2008，14，13： | 5 |
| 2 | Enhanced expression of interleukin-18 in serum and pancreas of patients with chronic pancreatitis显示文摘AIM: To investigate interleukin-18 (IL-18) in patients with chronic panreatitis (CP). METHODS: We studied 29 patients with CP and 30 healthy controls. Peripheral blood mononuclear cells (PBMC) were isolated and incubated with 50 mmol/L ethanol, lipopolysaccharide (LPS) (doses 25 g/L, 250 g/L, 2500 g/L) and both agents for 24 h. Levels of IL-18 in the supernatants, and levels of IL-18, IL-12, interferon (IFN)-γ and soluble CD14 in the serum were analysed by ELISA technique. Expression of IL-18 in PBMC was investigated by reverse-transcription (RT)-PCR. IL-18 protein levels in CP tissue and in normal pancreas were studied by ELISA technique. IL-18 levels in PBMC and pancreatic tissue were determined by Westernblot. Im-munohistochemistry for pancreatic IL-18 expression was performed. RESULTS: In patients, IL-18 serum levels were signifi-cantly enhanced by 76% (mean: 289.9 ± 167.7 ng/L) compared with controls (mean: 165.2 ± 43.6 ng/L; P < 0.0005). IL-12 levels were enhanced by 25% in patients (18.3 ± 7.3 ng/L) compared with controls (14.7 ± 6.8ng/L, P = 0.0576) although not reaching the statistical significance. IFN-γ and soluble CD14 levels were not in-creased. In vitro, LPS stimulated significantly and dose-dependently IL-18 secretion from PBMC. Incubation with ethanol reduced LPS-stimulated IL-18 secretion by about 50%. The mRNA expression of IL-18 in PBMC and the response of PBMC to ethanol and LPS was similar in CP patients and controls. In PBMC, no significant differences in IL-18 protein levels were detected between patients and controls. IL-18 protein levels were increased in CP tissues compared to normal pancreatic tissues. IL-18 was expressed by pancreatic acinar cells and by infiltrating inflammatory cells within the pancreas. CONCLUSION: IL-18 originates from the chronically inflammed pancreas and appears to be involved in the fibrotic destruction of the organ. | Alexander Schneider Stephan L Haas Ralf Hildenbrand Sren Siegmund Iris Reinhard Helmut Nakovics Manfred V Singer Peter Feick | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 3 | Phylogenetic relationships among genera of Aphidiinae(Hymenoptera: Braconidae) based on DNA sequence of the mitochondrial 16S rRNA gene显示文摘 | SRINIVAS K WOLFGANG V MANFRED M | 2000 | Syst Ent2000，25，： | 2 |
| 4 | A coaxial Gyro-TWT显示文摘 | Kartikeyan M V Iatrou C T Thumm Manfred | 2001 | IEEE Trans Plas Sci2001，29，1： | 1 |
| 5 | Central neurocytoma:clinical, immunohistologic and biologic findings of a human neuroglial progenitor tumor显示文摘 | Jose MV Manfred W Alexander V | 1996 | Surg Neurol1996，45，1： | 1 |
| 6 | An efficient multiplexgenotyping approach for detecting the major worldwide humanY-chromosome haplogroup显示文摘 | Mannis V O Arwin R Manfred K | 2011 | Int J Legal Med2011，125，： | 1 |
| 7 | Central neurocytoma:clinical,immunohistologic and biologic findings of a human neuroglial progenitor tumor显示文摘 | Jose MV Manfred W Alexander V | 1996 | Surg Neurol1996，45，： | 1 |
| 8 | Mitochondrial sulfide oxidation in Arenicola marina, Evidence for alternative electron pathways显示文摘 | SUSANNE V MANFRED K G | 2004 | European Journal of Biochemistry2004，235，12： | 1 |
| 9 | Robust constrained model predictive control using linear matrix inequalities 显示文摘 | Kothare V Manfred Morari | 1996 | Automatica1996，32，10： | 1 |
| 10 | Linear Parameter Varying Model Predictive Control for Steam Generator Level Control显示文摘 | Mayuresh V Kothare Bernard Mettler Manfred Morari | 1997 | Computers chem1997，，21： | 1 |
| 11 | Central neurocytoma:clinical,imm-unohistologic and biologic findings of a human neuroglial progenitor tumor显示文摘 | Jose MV Manfred W Alevander V | 1996 | Surg Neurol1996，45，1： | 1 |
| 12 | Robust constrained model predictive control using linear matrix inequalities显示文摘 | KOTHARE V MANFRED Morari | 1996 | Automatica1996，32，10： | 1 |
| 13 | Functional Principal Component Analysis of FMAI Data显示文摘 | ROBERTO V GEORG G MANFRED S | 2004 | Hu- man Brain Mapping2004，24，2： | 1 |
| 14 | Hypoxia inducible factor and its relationship to apoptosis and proliferation in lung cancer 显示文摘 | Manfred V Reet K | 2000 | Anticancer Res2000，20，3： | 1 |
| 15 | Hypoxia inducible factor and its relationshipto apoptosis and Proliferation in lung cancer 显示文摘 | Manfred V Reet K | 2000 | Anticaner2000，20，3： | 1 |
| 16 | Bacterial Release of Arsenic Ions and Organoarsenic Compounds from Soil Contaminated by Chemical Warfare Agents显示文摘 | MANFRED K KLAUS H FERNANDO V | 2001 | Chemosphere2001，42，： | 1 |
| 17 | Hypoxia-induced factor ( HIF-1) and its relationship to apoptosis and proliferation in lung cancer显示文摘 | Manfred V Reet K | 2000 | Anticancer Res2000，20，： | 1 |
| 18 | Long-term results of repair of anomalous origin of the left coronary artery from the pulmonary artery显示文摘 | Riidiger L Manfred V Jtirgen Hrer | 2007 | Ann Thorac Surg2007，83，4： | 1 |
| 19 | Hypoxia inducible factor and its relationship to apoptosis and Proliferation in lung cancer 显示文摘 | Manfred V Reet K | 2000 | Anticaner2000，20，3： | 1 |
| 20 | Switchable reactivity:the site-selective functionalization of trifluoromethyl-substituted pyrazoles显示文摘 | Manfred S Jean-Noel V Frederic L | 2002 | Eur J Org Chem2002，17，： | 1 |
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