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| 1 | Biomarkers of hypoxic-ischemic encephalopathy:a systematic review显示文摘Background Current diagnostic criteria for hypoxic–ischemic encephalopathy in the early hours lack objective measurement tools.Therefore,this systematic review aims to identify putative molecules that can be used in diagnosis in daily clinical practice(PROSPERO ID:CRD42021272610).Data sources Searches were performed in PubMed,Web of Science,and Science Direct databases until November 2020.English original papers analyzing samples from newborns>36 weeks that met at least two American College of Obstetricians and Gynecologists diagnostic criteria and/or imaging evidence of cerebral damage were included.Bias was assessed by the Newcastle–Ottawa Scale.The search and data extraction were verified by two authors separately.Results From 373 papers,30 met the inclusion criteria.Data from samples collected in the first 72 hours were extracted,and increased serum levels of neuron-specific enolase and S100-calcium-binding protein-B were associated with a worse prognosis in newborns that suffered an episode of perinatal asphyxia.In addition,the levels of glial fibrillary acidic protein,ubiquitin carboxyl terminal hydrolase isozyme-L1,glutamic pyruvic transaminase-2,lactate,and glucose were elevated in newborns diagnosed with hypoxic–ischemic encephalopathy.Moreover,pathway analysis revealed insulin-like growth factor signaling and alanine,aspartate and glutamate metabolism to be involved in the early molecular response to insult.Conclusions Neuron-specific enolase and S100-calcium-binding protein-B are potential biomarkers,since they are correlated with an unfavorable outcome of hypoxic-ischemic encephalopathy newborns.However,more studies are required to determine the sensitivity and specificity of this approach to be validated for clinical practice. | Ines Caramelo Margarida Coelho Miguel Rosado Carla M.P.Cardoso Alexandra Dinis Carlos B.Duarte Mario Graos Bruno Manadas | 2023 | World Journal of Pediatrics2023，19，6： | 2 |
| 2 | Intracellular signaling mechanisms in photodynamic therapy显示文摘 | Almeida RD Manadas B J Carvalho AP | 2004 | Biochem Bio- phys Acta2004，1704，2： | 1 |
| 3 | Preparation of dimethyl carbonate in the gas-phase reaction-release of Cl-compound from PdCl2 catalyst and effect of methyl chloroformate显示文摘 | Noriaki Manada Masato Murakami Toshio Kurafuji | 1994 | The Chemical Society of Japan1994，，11： | 1 |
| 4 | Neuroprotecti on by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways显示文摘 | ALMEIDA RD MANADAS BJ MELO CV | 2005 | J Cell Death Differ2005，12，10： | 1 |
| 5 | Process for the preparation of dialkyl carbonates显示文摘 | Manada Noriaki Koji Abe Toshio Kurafuji | 1995 | US: 5 403 9491995，，： | 1 |
| 6 | Pharmaceutical development of anticancer agents derived from marine sources 显示文摘 | Nuijen B Bouma M Manada C | 2000 | Anticancer Drugs2000，11，10： | 1 |
| 7 | Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways显示文摘 | Almeida RD Manadas B J Melo CV | 2005 | Cell Death Differ2005，12，10： | 1 |
| 8 | Intra- cellular signaling mechanisms in photodynamic therapy 显示文摘 | Almeida R D Manadas B J Carvalho A P | 2004 | Biochim Biophys Acta2004，1704，2： | 1 |
| 9 | Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways显示文摘 | Almeida RD Manadas BJ Melo CV | 2005 | Cell Death Differ2005，12，10： | 1 |
| 10 | Intracelluar signaling mechanisms in photodynamic therapy显示文摘 | Almeida RD Manadas BJ Carvalho AP | 2004 | Biochim Biophys Acta2004，1704，2： | 1 |
| 11 | Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways显示文摘 | Manadas BJ Melo CV | 2005 | Cell Death Differ2005，12，10： | 1 |
| 12 | Intracellular singaling mechanisms in photodynamic therapy显示文摘 | Almeida RD Manadas BJ Carvalho AP | 2004 | Biochim Biophys Acta2004，1704，： | 1 |
| 13 | Intracellular signaling mechanisms in photodynamic therapy显示文摘 | Almeida RD Manadas BJ Carvalho AP | 2004 | Biochim Biophys Acta2004，1704，2： | 1 |
| 14 | Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways显示文摘 | ALMEIDA R D MANADAS B J MELO C V | 2005 | Cell Death Differ2005，12，10： | 1 |
| 15 | Neuroprotection by BDNF against glutamate-induced apoptotic cell death is medi-ated by ERK and PI3-kinase pathways显示文摘 | Almeida RD Manadas BJ Melo CV | | 0，，10： | 1 |
| 16 | Intracellular signaling mechanisms in photodynamic therapy显示文摘 | Almeida R D Manadas B J Carvalho A P | 2004 | Biochim Biophys Acta2004，1704，2： | 1 |
| 17 | Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways显示文摘 | Almeida RD Manadas B J Melo CV | 2005 | Cell Death Differ2005，12，10： | 1 |
| 18 | Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK1/2 and PI3-kinase pathways显示文摘 | Almeida RD Manadas BJ Melo CV | 2005 | Cell Death Differ2005，12，： | 1 |
| 19 | Intracellular signaling mechanisms in photodynamic therapy显示文摘 | Almeida RD Manadas B J Carvalho AP | 2004 | Biochim Biophys Acta2004，1704，2： | 1 |
| 20 | Neuroprotection by BDNF against glutamate-induced apoptotic ceil death is mediated by ERK and P13-kinaes pathways显示文摘 | Almeida RD Manadas BJ Melo CV | | 0，，10： | 1 |
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