|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Unexpected metastasis of intraductal papillary neoplasm of the bile duct without an invasive component to the brain and lungs:A case report显示文摘BACKGROUND Despite an expanding number of studies on intraductal papillary neoplasm of the bile duct(IPNB),distant metastasis remains unexplained especially in cases of carcinoma in situ.In the present study,we report a rare and interesting case of IPNB without invasive components that later metastasized to lungs and brain.CASE SUMMARY A 69-year-old male was referred to our hospital due to suspected cholangiocarcinoma.Laboratory tests on admission reported a mild elevation of alkaline phosphatase,γ-glutamyl transpeptidase,and total bilirubin in serum.Endoscopic retrograde cholangiography revealed a filling defect in the common bile duct(CBD)extending to the left hepatic duct.Peroral cholangioscopy delineated a tumor in the CBD that had a papillary pattern.Multidetector computed tomography and magnetic resonance cholangiopancreatography detected partial blockage ot interlude in the CBD leading to cholestasis without evidence of metastasis.Therefore,a diagnosis of IPNB cT1N0M0 was established.Left hepatectomy with bile duct reconstruction was performed.Pathological examination confirmed an intraepithelial neoplasia pattern without an invasive component and an R0 resection achievement.The patient was monitored carefully by regular examinations.However,at 32 mo after the operation,a 26 mm tumor in the lungs and a 12 mm lesion in the brain were detected following a suspicious elevated CA 19-9 level.Video-assisted thoracoscopic surgery of left upper lobectomy and stereotactic radiotherapy are indicated.In addition to histopathological results,a genomic profiling analysis using whole exome sequencing subsequently confirmed lung metastasis originating from bile duct cancer.CONCLUSION This case highlights the important role of genomic profiling analysis using whole exome sequencing in identifying the origin of metastasis in patients with IPNB. | Nguyen Hai Nam Kojiro Taura Masashi Kanai Keita Fukuyama Norimitsu Uza Hirona Maeda Yojiro Yutaka Toyofumi F Chen-Yoshikawa Manabu Muto Shinji Uemoto | 2020 | World Journal of Gastroenterology2020，26，3： | 5 |
| 2 | Optimization of annealing temperature to reduce bias caused by a primer mismatch in multitemplate PCR 显示文摘 | Kousuke I Manabu F | 2001 | Applied and Environmental Microbiology2001，67，8： | 1 |
| 3 | Zero phase error tracking system with arbitrary specified gain characteristics显示文摘 | MANABU Y YASUYUKI F | 1997 | Transaction of ASME1997，119，： | 1 |
| 4 | Generalized optimal zero phase error tracking controller design显示文摘 | MANABU Y YASUYUKI F | 1999 | Journal of Dynamic Systems Measurement and Control1999，121，： | 1 |
| 5 | Antinocicep- five effect of cilnidipine, a novel N-type calcium chan- nel antagonist 显示文摘 | MANABU M OSAMU N SHIGEO F | 2000 | Brain Research2000，868，： | 1 |
| 6 | Predictive signs of discogenic lumbar pain on magnetic resonance imaging with discography correlation显示文摘 | Manabu Ito Kristine M Shiwei F | 1998 | Spine1998，23，11： | 1 |
| 7 | Inhibition of TNF-induced IL-6 by the TWEAK-Fn14 interaction in rheumatoid arthritis fibroblast like synoviocytes显示文摘 | Jiro Yamana Eric F Morand Tsuno Manabu | | 0，，02： | 1 |
| 8 | CD44 stimulation down-regulates fas expression and fas-mediated apoptosis of lung cancer cells显示文摘 | Manabu Y Yoshiya T Koichi F | 2001 | Int Immunol2001，13，： | 1 |
| 9 | Decreaase in tumor volume and histologic response to introarterial neoad juvant chemotherapy in patients with cervical and endometrial adenocarcinoma显示文摘 | Kentaro T Manabu K | 1997 | Gynecol Cncol1997，65，2： | 1 |
| 10 | Augmented ICOS expression in patients with early diffuse cutaneous systemic sclerosis显示文摘 | Minoru H Manabu F Takashi M | 2013 | Rheumatology2013，52，2： | 1 |
| 11 | Inhibition of laminin-8 in vivo using a novel poly (malic acid)-based carrier reduces glioma angiogenesis 显示文摘 | Manabu F Natalya M K Alexander V L | 2006 | Angiogenesis2006，，9： | 1 |
| 12 | Expression of P27 is associated withbax expression and spontaneous apoptosis in oral and oropharyngealcarcinoma显示文摘 | Manabu I Nobuyuki T | 1999 | Int J Cancer1999，84，： | 1 |
| 13 | Inhibition of TNF-induced IL-6 by the TWEAK-Fn14 interaction in rheumatoid arthritis fibroblast like synoviocytes显示文摘 | Yamana J Morand E F Manabu T | | 0，，02： | 1 |
| 14 | Altered blood B lymphocyte homeostasis in systemic sclerosis expanded naive B cells and diminished but activated memory B cells显示文摘 | Shinichi S Manabu F Minoru H | 2004 | Arthritis Rheum2004，50，6： | 1 |
| 15 | Long-term repeated biodesulfurization by immobilized Rhodococcus erythropolis KA2-5-1 cells显示文摘 | Manabu N Takuo K Kazuhito F | 2001 | Appl Microbiol Biotech2001，55，： | 1 |
| 16 | Polycefin, a new prototype of a mulitifunctional nanoconjugate based on poly(β-L-malic acid) for drug delivery显示文摘 | Lee B S Manabu F Khazenzon N M | 2006 | Bioconjugate Chem2006，17，2： | 1 |
| 17 | The effect of tackifier on phase structure and peel adhesion of a triblock copolymer pressure sensitive adhesive显示文摘 | MARIKO S KAZUYA F MANABU A etal | 2008 | International Journal of Adhesives & Adhesion2008，28，： | 1 |
| 18 | Polycefin,a new prototype of a mulitifunctional nanoconjugate based on poly (β-L-malic acid) for drug delivery显示文摘 | Lee B S Manabu F Khazenzon N M | | 0，，02： | 1 |
| 19 | Predict ivesigns of discogeniclnm bar pain on magnet icresonance imagingwith discography correlation显示文摘 | Manabu ITO Kristine M Shiwei F | 1998 | Spine1998，23，11： | 1 |
| 20 | Frequent genetic heterogeneity in the clonal evolution of gynecological carcinosarcoma and its influence on phenotypic diversity 显示文摘 | Hiroaki F Manabu Y Zhu XG | 2000 | Cancer Res2000，60，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员