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| 1 | WONCA研究论文摘要汇编——急性颅内出血后血压变异性及转归:INTERACT2研究的析因分析,一项随机对照试验显示文摘背景高血压是急性脑卒中的预后因子,血压变异性或许可以独立预测脑卒中的转归。我们评估了血压变异性对INTERACT2参试者脑卒中预后的预测价值, INTERACT2是一项开放标签随机对照试验。方法 INTERACT2将患有自发性颅内出血(ICH)、高收缩压(150~220 mm Hg)、对早期降压强化疗法无明确适应证或禁忌证的2839例成人纳入研究。将患者随机分为强化治疗组(经静脉给药,1 h内目标收缩压降至<140 mm Hg )和指南推荐的治疗组( ICH 后6 h 内,目标收缩压降至<180 mm Hg)。主要转归为死亡或90 d内发生生活大部分无法自理(改良Rankin量表评分≥3分);次要转归为90 d内改良Rankin量表评分发生顺序移动,调查员在评分时并不知晓患者接受了哪种治疗。根据标准定义血压变异性:在发病头24 h (超急性期)进行5次测量,在发病后2~7 d (急性期)进行不少于12次的测量。采用比例优势逻辑回归模型评价血压变异性与转归之间的关联。血压变异性关键指标为收缩压的标准差,按五分位数加以分类。发现研究者对2645例(93.2%)处于超急性期的患者和2347例(82.7%)处于急性期的患者进行了调查。将两个治疗组的数据一起分析,在超急性期〔最高五分位数校正OR=1.41,95%CI (1.05,1.90); P=0.0167〕和急性期〔最高五分位数校正OR=1.57,95%CI (1.14,2.17); P=0.0124〕,收缩压的标准差与主要转归均呈线性相关。对转归最强的预测指标为超急性期最高收缩压和急性期收缩压的标准差为结果的最强预示因子。对次要转归进行分析,得到的结果与以上结果相似〔超急性期最高五分位数,校正OR=1.43,95%CI (1.14,1.80); P=0.0014;急性期OR=1.46,95%CI (1.13,1.88); P=0.0044〕。解释收缩压变异性似乎可预测急性颅内出血患者的不良转归。早期治疗将收缩压降至140 mm Hg以下获得的收益,可通过平稳并持续血压控制进行强化,避免出现收缩压峰值尤为重要。 | Manning L Hirakawa Y Arima H 周淑新 | 2014 | 中国全科医学2014，17，21： | 56 |
| 2 | Interplay between inflammation,immune system and neuronal pathways:Effect on gastrointestinal motility显示文摘Sepsis is a systemic inflammatory response representing the leading cause of death in critically ill patients,mostly due to multiple organ failure.The gastrointestinal tract plays a pivotal role in the pathogenesis of sepsisinduced multiple organ failure through intestinal barrier dysfunction,bacterial translocation and ileus.In this review we address the role of the gastrointestinal tract,the mediators,cell types and transduction pathways involved,based on experimental data obtained from models of inflammation-induced ileus and (preliminary) clinical data.The complex interplay within the gastrointestinal wall between mast cells,residential macrophages and glial cells on the one hand,and neurons and smooth muscle cells on the other hand,involves intracellular signaling pathways,Toll-like receptors and a plethora of neuroactive substances such as nitric oxide,prostaglandins,cytokines,chemokines,growth factors,tryptases and hormones.Multidirectional signaling between the different components in the gastrointestinal wall,the spinal cord and central nervous system impacts inflammation and its consequences.We propose that novel therapeutic strategies should target inflammation on the one hand and gastrointestinal motility,gas-trointestinal sensitivity and even pain signaling on the other hand,for instance by impeding afferent neuronal signaling,by activation of the vagal anti-inflammatory pathway or by the use of pharmacological agents such as ghrelin and ghrelin agonists or drugs interfering with the endocannabinoid system. | Benedicte Y De Winter Joris G De Man | 2010 | World Journal of Gastroenterology2010，16，44： | 23 |
| 3 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 4 | Structural basis for dsRNA recognition by NS1 protein of influenza A virus显示文摘流行性感冒 A 病毒是引起周期的流行威胁的重要人的病原体。Nonstructural 蛋白质 1 (NS1 ) 流行性感冒的蛋白质一个病毒(NS1A ) 对主人防卫防护病毒。这里,我们报导在 1.7 点绑在双 stranded RNA (dsRNA ) 的 NS1A RNA 有约束力的领域(RBD ) 的水晶结构 ? 。NS1A RBD 形成 homodimer 由它二聚的反平行的伪 - helices 形成的保存凹面表面在一个长度无关的模式认出 A 形式 dsRNA 的主要的沟。dsRNA 被广泛的氢契约被一双不变的精氨酸(Arg38 ) 从两单体抛锚。根据结构的观察,唯一的 Arg38-Arg38 对和二 Arg35-Arg46 配对的等温的滴定热量测定试金表演为 dsRNA 绑定是关键的,并且那 Ser42 和 Thr49 为 dsRNA 绑定也是重要的。Agrobacterium 合作渗入试金进一步支持唯一的 Arg38 对在在 vivo 有约束力的 dsRNA 起重要作用。 | Ao Cheng Sek Man Wong Y Adam Yuan | 2009 | Cell Research2009，19，2： | 8 |
| 5 | Neuroanatomy of lower gastrointestinal pain disorders显示文摘Chronic abdominal pain accompanying intestinal inflammation emerges from the hyperresponsiveness of neuronal,immune and endocrine signaling pathways within the intestines,the peripheral and the central nervous system.In this article we review how the sensory nerve information from the healthy and the hypersensitive bowel is encoded and conveyed to the brain.The gut milieu is continuously monitored by intrinsic enteric afferents,and an extrinsic nervous network comprising vagal,pelvic and splanchnic afferents.The extrinsic afferents convey gut stimuli to second order neurons within the superficial spinal cord layers.These neurons cross the white commissure and ascend in the anterolateral quadrant and in the ipsilateral dorsal column of the dorsal horn to higher brain centers,mostly subserving regulatory functions.Within the supraspinal regions and the brainstem,pathways descend to modulate the sensory input.Because of this multiple level control,only a small proportion of gut signals actually reaches the level of consciousness to induce sensation or pain.In inflammatory bowel disease(IBD)and irritable bowel syndrome(IBS)patients,however,long-term neuroplastic changes have occurred in the brain-gut axis which results in chronic abdominal pain.This sensitization may be driven on the one hand by peripheral mechanisms within the intestinal wall which encompasses an interplay between immunocytes,enterochromaffin cells,resident macrophages,neurons and smooth muscles.On the other hand,neuronal synaptic changes along with increased neurotransmitter release in the spinal cord and brain leads to a state of central wind-up.Also life factors such as but not limited to inflammation and stress contribute to hypersensitivity.All together,the degree to which each of these mechanisms contribute to hypersensitivity in IBD and IBS might be diseaseand even patient-dependent.Mapping of sensitization throughout animal and human studies may significantly improve our understanding of sensitization in IBD and IBS.On the long run,this knowledge can be put forward in potential therapeutic targets for abdominal pain in these conditions. | Wim Vermeulen Joris G De Man Paul A Pelckmans Benedicte Y De Winter | 2014 | World Journal of Gastroenterology2014，20，4： | 7 |
| 6 | Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases显示文摘Proteases, enzymes catalyzing the hydrolysis of peptide bonds, are present at high concentrations in the gastrointestinal tract. Besides their well-known role in the digestive process, they also function as signaling molecules through the activation of protease-activated receptors(PARs). Based on their chemical mechanism for catalysis, proteases can be classified into several classes: serine, cysteine, aspartic, metallo- and threonine proteases represent the mammalian protease families. In particular, the class of serine proteases will play a significant role in this review. In the last decades, proteases have been suggested to play a key role in the pathogenesis of visceral hypersensitivity, which is a major factor contributing to abdominal pain in patients with inflammatory bowel diseases and/or irritable bowel syndrome. So far, only a few preclinical animal studies have investigated the effect of protease inhibitors specifically on visceral sensitivity while their effect on inflammation is described in more detail. In our accompanying review we describe their effect on gastrointestinal permeability. On account of their promising results in the field of visceral hypersensitivity, further research is warranted. The aim of this review is to give an overview on the concept of visceral hypersensitivity as well as on the physiological and pathophysiological functions of proteases herein. | Hannah Ceuleers Hanne Van Spaendonk Nikita Hanning Jelena Heirbaut Anne-Marie Lambeir Jurgen Joossens Koen Augustyns Joris G De Man Ingrid De Meester Benedicte Y De Winter | 2016 | World Journal of Gastroenterology2016，22，47： | 7 |
| 7 | Regulation of intestinal permeability: The role of proteases显示文摘The gastrointestinal barrier is-with approximately 400 m^2-the human body's largest surface separating the external environment from the internal milieu. This barrier serves a dual function: permitting the absorption of nutrients, water and electrolytes on the one hand, while limiting host contact with noxious luminal antigens on the other hand. To maintain this selective barrier, junction protein complexes seal the intercellular space between adjacent epithelial cells and regulate the paracellular transport. Increased intestinal permeability is associated with and suggested as a player in the pathophysiology of various gastrointestinal and extraintestinal diseases such as inflammatory bowel disease, celiac disease and type 1 diabetes. The gastrointestinal tract is exposed to high levels of endogenous and exogenous proteases, both in the lumen and in the mucosa. There is increasing evidence to suggest that a dysregulation of the protease/antiprotease balance in the gut contributes to epithelial damage and increased permeability. Excessive proteolysis leads to direct cleavage of intercellular junction proteins, or to opening of the junction proteins via activation of protease activated receptors. In addition, proteases regulate the activity and availability of cytokines and growth factors, which are also known modulators of intestinal permeability. This review aims at outlining the mechanisms by which proteases alter the intestinal permeability. More knowledge on the role of proteases in mucosal homeostasis and gastrointestinal barrier function will definitely contribute to the identification of new therapeutic targets for permeability-related diseases. | Hanne Van Spaendonk Hannah Ceuleers Leonie Witters Eveline Patteet Jurgen Joossens Koen Augustyns Anne-Marie Lambeir Ingrid De Meester Joris G De Man Benedicte Y De Winter | 2017 | World Journal of Gastroenterology2017，23，12： | 6 |
| 8 | Emission spectra produced by pulsed laser ablation of metal Al at different ambient pressures显示文摘INTERACTION between laser and material is closely related to background besides properties oflaser and material. The interaction process can be influenced to a great extent by ambient at-mosphere and pressures. In the present work, a time and space resolved diagnostic tech-nique was used to study the emission spectrum from the plume produced by a pulsed laser on | Man, BY Miao, Y Guo, XX Wang, GT Hu, XR Wang, XT | 1997 | Chinese Science Bulletin1997，42，13： | 2 |
| 9 | Hydrogen effect on the cavitation erosion resistance of AISI 316L stainless steel laser surface modified with NiTi显示文摘 | Chiu K Y C F T Man H C | 2007 | Materials Letters2007，61，1： | 1 |
| 10 | Subsideband generation and modulational instability lasing in a fiber soliton laser显示文摘 | TAN D Y FLEMING S MAN W S | 2001 | JOSA B2001，18，10： | 1 |
| 11 | A comparative analysis of low-dose metronomic cyclophosphamide reveals absent or low-grade toxicity on tissues highly sensitive to the toxic effects of maximum tolerated dose regimens显示文摘 | Emmenegger U Man S Shaked Y | 2004 | Cancer Res2004，64，11： | 1 |
| 12 | Visible-light-driven photoeatalyst of Bi2WO6 nanoparticles prepared via amorphous complex precursor and photocatalytic properties显示文摘 | Zhang S C Zhang C Man Y | 2006 | J Solid State Chem2006，179，： | 1 |
| 13 | Mitogenicity of the recombinant myco- bacterial 27-kilodalton lipoprotein is not connected to its anti- protective effect 显示文摘 | Hovav AH Davidoviteh L Nussbaum G Mullerad J Fish- man Y Bercovier H | 2004 | Infect Immun2004，72，6： | 1 |
| 14 | Urinary leukotriene F4 levels during early and late asthmatic responses 显示文摘 | Manning PJ Rokach J Malo JL Ethier D Cartier A Girard Y Charleson S O'Byrne PM | 1990 | J Allergy Clin Immunol1990，86，2： | 1 |
| 15 | The competitiveness of small and medium enterprises:a conceptualization with foeus on entrepreneurial competencies 显示文摘 | MAN T W Y LAU T CHAN K F | 2002 | Journal of Business Venturing2002，17，： | 1 |
| 16 | Antitumor and anti- metastatic activities of Rhizoma Paridis saponins 显示文摘 | Man S L Gao W Y Zhang Y J | 2009 | Steroids2009，74，1314： | 1 |
| 17 | Microstructure,oxidation and H2-permeation resistance of TiAlN films deposited by DC magnetron sputtering technique显示文摘 | Man B Y Guzman L Miotello A | 2004 | Surf Coat Techn2004，，： | 1 |
| 18 | Developing a behaviour-centred model of entre preneurial learning显示文摘 | Man T W Y | 2012 | Journal of Small Business and Enter- prise Development2012，19，3： | 1 |
| 19 | Non-singular terminal sliding mode control of rigid manipulators显示文摘 | Feng Y Yu X H Man Z H | 2002 | Automatica2002，38，12： | 1 |
| 20 | Effects of natural and synthetic antioxi- dants on changes in refined, bleached, and deodorized palm olein during deep - fat frying of potato chips 显示文摘 | Man Y B Tan C P | 1999 | Journal of the American Oil Chemists'' Society1999，76，3： | 1 |
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