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| 1 | New prospecting progress using information and big data of coal and oil exploration holes on sandstone-type uranium deposit in North China显示文摘1.Objective A series of Mesozoic-Cenozoic continental sedimentary basins exist in North China,coexisting with coal,oil/gas,and salt resources.Many previous drilling projects have been conducted within these basins to explore coal,petroleum,and mineral resources,however,these data have not been integrated due to different industries owners.In order to efficiently explore the large-sized,easily extracted,and environmentally friendly,sandstone-type uranium deposits,previous coal and oil exploration drilling-hole data are systematically collected, processed,and analyzed to improve the sandstone-type uranium prospecting exploitation.At the same time,we also discussed the uranium source,ore-forming process and model for the sandstone-type uranium deposits. | Ruo-shi Jin Pei-sen Miao Xian-zhang Sima Reng-An Yu Yin-hang Cheng Chao Tang Tian-fu Zhang Cong Ao Xue-ming Teng | 2018 | China Geology2018，1，1： | 12 |
| 2 | Advanced data analytics for enhancing building performances: From data-driven to big data-driven approaches显示文摘Buildings have a significant impact on global sustainability.During the past decades,a wide variety of studies have been conducted throughout the building lifecycle for improving the building performance.Data-driven approach has been widely adopted owing to less detailed building information required and high computational efficiency for online applications.Recent advances in information technologies and data science have enabled convenient access,storage,and analysis of massive on-site measurements,bringing about a new big-data-driven research paradigm.This paper presents a critical review of data-driven methods,particularly those methods based on larger datasets,for building energy modeling and their practical applications for improving building performances.This paper is organized based on the four essential phases of big-data-driven modeling,i.e.,data preprocessing,model development,knowledge post-processing,and practical applications throughout the building lifecycle.Typical data analysis and application methods have been summarized and compared at each stage,based upon which in-depth discussions and future research directions have been presented.This review demonstrates that the insights obtained from big building data can be extremely helpful for enriching the existing knowledge repository regarding building energy modeling.Furthermore,considering the ever-increasing development of smart buildings and IoT-driven smart cities,the big data-driven research paradigm will become an essential supplement to existing scientific research methods in the building sector. | Cheng Fan Da Yan Fu Xiao Ao Li Jingjing An Xuyuan Kang | 2021 | Building Simulation2021，14，1： | 10 |
| 3 | Aging characteristic of Cu-0.6Cr-0.15Zr-0.05Mg-0.02Si alloy containing trace rare earth yttrium显示文摘The aging characteristic of Cu-0.6Cr-0.15Zr-0.05Mg-0.02Si alloy containing trace rare earth yttrium was investigated. The results showed that Cu-0.6Cr-0.15Zr-0.05Mg-0.02Si alloy obtained good comprehensive performance after 80% rolling and then aging at 480℃ for 1 h; the hardness and electrical conductivity reached HV 150 and 85.5% IACS, respectively. Increasing aging temperature accelerated aging precipitation. The time for attaining peak hardness was postponed, the precipitates were finer (2-4 nm), and the interparticle spacing was shorter due to yttrium addition. The hardness and electrical conductivity of the Y-containing alloy after 80% deformation and then aging at 480℃ for 45 min reached HV 174 and 82.1% IACS, respectively. | YU Fangxin CHENG Jianyi AO Xuewen | 2011 | Rare Metals2011，30，5： | 8 |
| 4 | Structural basis for dsRNA recognition by NS1 protein of influenza A virus显示文摘流行性感冒 A 病毒是引起周期的流行威胁的重要人的病原体。Nonstructural 蛋白质 1 (NS1 ) 流行性感冒的蛋白质一个病毒(NS1A ) 对主人防卫防护病毒。这里,我们报导在 1.7 点绑在双 stranded RNA (dsRNA ) 的 NS1A RNA 有约束力的领域(RBD ) 的水晶结构 ? 。NS1A RBD 形成 homodimer 由它二聚的反平行的伪 - helices 形成的保存凹面表面在一个长度无关的模式认出 A 形式 dsRNA 的主要的沟。dsRNA 被广泛的氢契约被一双不变的精氨酸(Arg38 ) 从两单体抛锚。根据结构的观察,唯一的 Arg38-Arg38 对和二 Arg35-Arg46 配对的等温的滴定热量测定试金表演为 dsRNA 绑定是关键的,并且那 Ser42 和 Thr49 为 dsRNA 绑定也是重要的。Agrobacterium 合作渗入试金进一步支持唯一的 Arg38 对在在 vivo 有约束力的 dsRNA 起重要作用。 | Ao Cheng Sek Man Wong Y Adam Yuan | 2009 | Cell Research2009，19，2： | 8 |
| 5 | Cryo-self-assembled silk fibroin sponge as a biodegradable platform for enzyme-responsive delivery of exosomes显示文摘Although advances in protein assembly preparation have provided a new platform for drug delivery during tissue engineering,achieving long-term controlled exosome delivery remains a significant challenge.Diffusion-dominated exosome release using protein hydrogels results in burst release of exosomes.Here,a fibroin-based cryo-sponge was developed to provide controlled exosome release.Fibroin chains can self-assemble into silk I structures under ice-cold conditions when annealed above the glass transition temperature.Exosome release is enzyme-responsive,with rates primarily determined by enzymatic degradation of the scaffolds.In vivo experiments have demonstrated that exosomes remain in undigested sponge material for two months,superior to their retention in fibrin glue,a commonly used biomaterial in clinical practice.Fibroin cryo-sponges were implanted subcutaneously in nude mice.The exosome-containing sponge group exhibited better neovascularization and tissue ingrowth effects,demonstrating the efficacy of this exosome-encapsulating strategy by realizing sustained release and maintaining exosome bioactivity.These silk fibroin cryo-sponges containing exosomes provide a new platform for future studies of exosome therapy. | Muyang Sun Qi Li Huilei Yu Jin Cheng Nier Wu Weili Shi Fengyuan Zhao Zhenxing Shao Qingyang Meng Haifeng Chen Xiaoqing Hu Yingfang Ao | 2022 | Bioactive Materials2022，7，2： | 4 |
| 6 | Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1显示文摘As a terpenoids natural product isolated from the plant Thunder God Vine,Celastrol is widely studied for its pharmacological activities,including anti-tumor activities.The clinical application of Celastrol is strictly limited due to its severe side effects,whereas previously revealed targets and mechanism of Celastrol seldom reduce its in vivo toxicity via structural optimization.Target identification has a far-reaching influence on the development of innovative drugs,and omics data has been widely used for unbiased target prediction.However,it is difficult to enrich target of specific phenotype from thousands of genes or proteins,especially for natural products with broad promising activities.Here,we developed a text-mining-based web-server tool to enrich targets from omics data of inquired compounds.Then peroxiredoxin 1(PRDX1)was identified as the ROS-manipulating target protein of Celastrol in colorectal cancer.Our solved high-resolution crystal structure revealed the unique covalent binding mode of Celastrol with PRDX1.New derivative compound 19-048 with improved potency against PRDX1 and selectivity towards PRDX2~PRDX6 were synthesized based on crystal structure analysis.Both Celastrol and 19-048 effectively suppressed the proliferation of colorectal cancer cells.The anti-tumor efficacy of Celastrol and 19-048 was significantly diminished on xenograft nude mice bearing PRDX1 knock-down colorectal cancer cells.Several downstream genes of p53 signaling pathway were dramatically up-regulated with Celastrol or 19-048 treatment.Our findings reveal that the side effects of Celastrol could be reduced via structural modification,and PRDX1 inhibition is promising for the treatment of colorectal cancer. | Heng Xu Hongfang Zhao Chunyong Ding Defang Jiang Zijie Zhao Yang Li Xiaoyu Ding Jing Gao Hu Zhou Cheng Luo Guoqiang Chen Ao Zhang Ying Xu Hao Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 3 |
| 7 | Super-resolution of geosynchronous synthetic aperture radar images using dialectical GANs显示文摘Dear editor,The concept of geosynchronous synthetic aperture radar (GEO SAR) system was conceived in an effort to realize a quick observation of emergency disasters (e.g., landslides and earthquakes)[1].The novel GEO SAR system has the significant advantages of short-revisit time and large coverage and facilitates the nearly continuous observation of target regions, unlike the currently operatinglow earth orbit (LEO) SARs [2]. | Yuanhao LI Dongyang AO Corneliu Octavian DUMITRU Cheng HU Mihai DATCU | 2019 | Science China(Information Sciences)2019，62，10： | 3 |
| 8 | Ultrafast photocatalytic degradation of nitenpyram by 2D ultrathin Bi2WO6:mechanism,pathways and environmental factors显示文摘As a common insecticide,nitenpyram(NTP)seriously threatens the human health and environmental safety.In this work,a visible-light-responsive photocata-lyst two-dimensional(2D)Bi_(2)WO_(6) was synthesized and applied to degrade NTP.Compared with bulk Bi_(2)WO_(6),the 2D Bi_(2)WO_(6)exhibits better photocatalytic performance for NTP degradation under visible-light irradiation.The enhanced activity can be ascribed to the unique 2D struc-ture which would induce to higher efficiency of carrier separation.Moreover,hole(h+)plays a major role(and·O^(2-))in the degradation of NTP.Based on the interme-diates detected by high-performance liquid chromatogra-phy-mass spectrometry(HPLC-MS),the degradation pathway of NTP was proposed.In addition,the influence of typical environmental factors(pH,water matrix,inorganic cations and common anions)on the degradation of NTP was also investigated.This work not only helps people to understand the degradation of pesticides in actual water bodies,but also provides reference for the subsequent treatment of agricultural wastewater. | Yuan-Hao Cheng Juan Chen Hui-Nan Che Yan-Hui Ao Bin Liu | 2022 | Rare Metals2022，41，7： | 3 |
| 9 | Development of an ANN-based building energy model for information-poor buildings using transfer learning显示文摘Accurate building energy prediction is vital to develop optimal control strategies to enhance building energy efficiency and energy flexibility.In recent years,the data-driven approach based on machine learning algorithms has been widely adopted for building energy prediction due to the availability of massive data in building automation systems(BASs),which automatically collect and store real-time building operational data.For new buildings and most existing buildings without installing advanced BASs,there is a lack of sufficient data to train data-driven predictive models.Transfer learning is a promising method to develop accurate and reliable data-driven building energy prediction models with limited training data by taking advantage of the rich data/knowledge obtained from other buildings.Few studies focused on the influences of source building datasets,pre-training data volume,and training data volume on the performance of the transfer learning method.The present study aims to develop a transfer learning-based ANN model for one-hour ahead building energy prediction to fill this research gap.Around 400 non-residential buildings’data from the open-source Building Genome Project are used to test the proposed method.Extensive analysis demonstrates that transfer learning can effectively improve the accuracy of BPNN-based building energy models for information-poor buildings with very limited training data.The most influential building features which influence the effectiveness of transfer learning are found to be building usage and industry.The research outcomes can provide guidance for implementation of transfer learning,especially in selecting appropriate source buildings and datasets for developing accurate building energy prediction models. | Ao Li Fu Xiao Cheng Fan Maomao Hu | 2021 | Building Simulation2021，14，1： | 3 |
| 10 | An Outbreak of SARS in a Diabetes Room of a General Hospital without Infected Medical Staff显示文摘Objective To investigate the epidemiologic features of an outbreak of SARS that occurred in a single diabetes room of a general hospital in Beijing in late March 2003.Methods Field investigation was carried out in the ward,the nursing log and the hospitalization medical record of correlative patients were consulted.SARS-CoV in serum specimen from SARS patient was detected by PCR.Results The room where SARS outbreak occurred was on the 13th floor of the 16-story main ward building.There were 6 beds in the room,living with 6 female patients(aged 45-67)who were all hospitalized due to type2 diabetes.On March 24,2003,Patient 1 began to have a fever and cough,chest X-ray showed pneumonia.Five and six days later,Patient 2 and Patient 3 began to have a fever,respectively.Finally,all of these 3 patients died.Their beds were all at the same side of the room,and the other 3 patients at the opposite side were not infected.Serum SARS CoV-RNA of the Patient 3 was positive by nest-PCR.The daughter-in-law of Patient 1who accompanied Patient 1 by the bedside several days,mainly near the window,upwind of Patient 1,was not infected.Medical staff,family members and visitors of the 6 patients were not infected.Conclusions This outbreak was not transmitted by aerosol.The distance droplets travels could be up to 3.43 meters.Droplet spread has direction,and the droplets direction of propagation is closely related with the wind direction and speed.Those at the downwind position of SARS patients were susceptible to be infected.Medical staff wore face masks and good natural ventilation of this ward building may be important reasons for the prevention of infection. | Chun-ling Liu Jun Cheng He Gao Bo Zhang Qun Yuan Ao Tong Yi-an Liang Hong Tang Xiao-hong Guan | 2013 | 国际感染病学(电子版)2013，2，4： | 3 |
| 11 | The clinical relevance of MBL2 gene polymorphism and sepsis显示文摘Objective:To detect the clinical relevance of mannose-binding lectin 2(MBL2) gene polymorphism and sepsis in Chinese lived in Hainan island.Methods: Blood samples from 57 patients with sepsis and 69 patients without sepsis were collected in the ICU of several large hospitals in Hainan province. Genomic DNA was extracted from whole blood and then PCR purification product was sequenced and typed by 3730 sequencing analyzer. The concentration of MBIL2 in serum was detected by ELISA.Results: We found that genotype and allele distributions in two groups were in accordance with the Hardy-Weinberg Equilibrium. The frequency of GA genotype was significantly higher than that in non-sepsis group(P=0.013). A allele frequency in sepsis group was also much higher than that in non-sepsis group(P=0.028).Logister regression analysis showed that the patients who carried A allele were more prone to get sepsis than G allele carrier(P=0.014, OR=2,550, 95%CI=1.207-5.386). The MBL2 level in serum of sepsis patients with genotype GG and GA was significantly lower than that in non-sepsis group(P<0.05). In sepsis group, the MBL2 serum level of patients with genotype GA was obviously lower than that in patients with genotype GG(P<0.05).Conclusions: The variation of rs 1800450 G→A increased the incidence of sepsis and decreased the level of MBL2 in serum. | Shao-Wen Cheng Li-Na Xian Zhi-Xing Lin Xue Ao Jun-Yi Yao Ying-Qing Li Yong-Yan Li Xiu-Ru Li Wei-Cheng Wang Chuan-Zhu Lyu Ying Li | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，3： | 2 |
| 12 | Plant Selection of Constructed Wetlands for Treatment of Piggery Wastewater显示文摘Piggery wastewater contains high concentrations of organic matter and ammonia nitrogen,and it is difficult to treat it and make the discharged wastewater to meet the standard. Since the treatment of piggery wastewater treated under anaerobic conditions by traditional aerobic methods requires large investment,high running expense and strict management,breeding enterprises could hardly accept the technique. According to the characteristics of piggery wastewater,Pennisetum sp. + Rumex acetosa Linn and Populus + Nerium oleander can be planted in constructed wetlands to treat piggery wastewater,which can improve the treatment effect of piggery wastewater by constructed wetlands,solve the difficulty of wastewater treatment in winter,and bring obvious economic benefit. | Ao Ziqiang Zhang Jie Peng Guiqun Fu Jiaqi Jiang Cheng Xiong Jihai | 2017 | Meteorological and Environmental Research2017，8，2： | 2 |
| 13 | Expression of pseudorabies virus gE epitopes in Pichia pastoris and its utilization in an indirect PRV gE-ELISA显示文摘 | Ao J Q Wang J W Cheng X H | 2003 | Virol Meth2003，11，4： | 1 |
| 14 | Association of Comorbid Asthma and the Efficacy of Bioabsorbable Steroid-eluting Sinus Stents Implanted After Endoscopic Sinus Surgery in Patients with Chronic Rhinosinusitis with Nasal Polyps显示文摘Objective To identify factors affecting the efficacy of steroid-eluting sinus stents implanted after endoscopic sinus surgery(ESS)in patients with chronic rhinosinusitis with nasal polyps(CRSwNP).Methods We performed a post-hoc analysis of a randomized self-controlled clinical trial on post-operative implantation of bioabsorbable steroid-eluting stents in patients with CRSwNP.Univariate logistic regression analysis was conducted to identify which of the following factors affect the response to post-operative stent implantation:sex,serum eosinophil levels,history of prior surgery,endoscopic scores,and comorbid conditions(asthma and allergic rhinitis).The primary outcome was the rate of post-operative intervention on day 30,and the secondary outcome was the rate of polypoid tissue formation(grades 2–3)on days 14,30,and 90.Results A total of 151 patients with CRSwNP were included in the post-hoc analysis.Asthma was identified as the only risk factor for a poor response to steroid-eluting sinus stents on post-operative day 30,with an odds ratio of 23.71(95%CI,2.81,200.16;P=0.004)for the need for post-operative intervention and 19(95%CI,2.20,164.16;P=0.003)for moderate-to-severe polypoid tissue formation.In addition,the asthmatic group showed higher rates of post-operative intervention and polypoid tissue formation than the non-asthmatic group on post-operative day 30.Blood eosinophil levels were not identified as a risk factor for poor outcomes after stent implantation.Conclusion Comorbid asthma,but not blood eosinophil level,impairs the efficacy of steroid-eluting sinus stents in the short term after ESS in patients with CRSwNP. | Ao HUANG Tao LI Min-shan LI Zhen-xiao HUANG De-hui WANG Lei CHENG Bing ZHOU Heng WANG Zheng LIU | 2023 | Current Medical Science2023，43，5： | 1 |
| 15 | Coping strategies,illness perception,anxiety,and depression of patients with idiopathic constipation:A population-based study显示文摘 | Cheng C Chan AO Hui WM | 2003 | Aliment Pharmacol Ther2003，18，： | 1 |
| 16 | On modeling malware propagation in generalized social networks显示文摘 | Cheng S M Ao W C Chen P Y | | 0，，1： | 1 |
| 17 | Zearalenone toxicosis on reproduction as estrogen receptor selective modulator and alleviation of zearalenone biodegradative agent in pregnant sows显示文摘Background:Zearalenone(ZEA)is a resorcylic acid lactone derivative derived from various Fusarium species that are widely found in food and feeds.The molecular structure of ZEA resembles that of the mammalian hormone 17β-oestradiol,thus zearalenone and its metabolites are known to compete with endogenous hormones for estrogen receptors binding sites and to activate transcription of oestrogen-responsive genes.However,the effect of long-term low-dose ZEA exposure on the reproductive response to Bacillus subtilis ANSB01G culture for first-parity gilts has not yet been investigated.This study was conducted to investigate the toxic effects of ZEA as an estrogen receptor selective modulator and the alleviating effects of Bacillus subtilis ANSB01G cultures as ZEA biodegraders in pregnant sows during their first parity.Results:A total of 80 first-parity gilts(Yorkshire×Landrace)were randomly assigned to four dietary treatments during gestation:CO(positive control);MO(negative control,246μg ZEA/kg diet);COA(CO+B.subtilis ANSB01G culture with 2×10^(9)CFU/kg diet);MOA(MO+B.subtilis ANSB01G culture with 2×10^(9)CFU/kg diet).There were 20 replications per treatment with one gilt per replicate.Feeding low-dose ZEA naturally contaminated diets disordered most of reproductive hormones secretion and affected estrogen receptor-αand estrogen receptor-βconcentrations in serum and specific organs and led to moderate histopathological changes of gilts,but did not cause significant detrimental effects on reproductive performance.The addition of Bacillus subtilis ANSB01G culture to the diet can effectively relieve the competence of ZEA to estrogen receptor and the disturbance of reproductive hormones secretion,and then ameliorate toxicosis of ZEA in gilts.Conclusions:Collectively,our study investigated the effects of feeding low-dose ZEA on reproduction in pregnant sows during their first parity.Feeding low-dose ZEA could modulate estrogen receptor-αand-βconcentrations in specific organs,cause disturbance of reproductive hormones and vulva swelling,and damage organ histopathology and up-regulate apoptosis in sow models.Diet with Bacillus subtilis ANSB01G alleviated negative effects of the ZEA on gilts to some extent. | Jianchuan Zhou Lihong Zhao Shimeng Huang Qingxiu Liu Xiang Ao Yuanpei Lei Cheng Ji Qiugang Ma | 2022 | Journal of Animal Science and Biotechnology2022，13，4： | 1 |
| 18 | Coping strategies, illness per ception,anxiety, and depression of patients with idiopathic con- stipation:A population- based study显示文摘 | Cheng C Chan AO Hui WM | 2003 | Aliment Pharmacol T- her2003，18，3： | 1 |
| 19 | Copying Strategies, ill-ness perception, anxiety and depression of patients with id- iopathic constipation; a population-based study 显示文摘 | Cheng C Chao AO Hui WM | 2003 | Aliment Pharmocal Ther2003，18，3： | 1 |
| 20 | Coping strategies,illness perception,anxiety,and depression of patients with idiopathic constipation:A population based study显示文摘 | Cheng C Chan AO Hui WM | 2003 | AlimentPharmacologic Ther2003，18，： | 1 |
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