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| 1 | Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation显示文摘AIM: To investigate coping mechanisms, constipation symptoms and anorectal physiology in 80 constipated subjects and 18 controls.METHODS: Constipation was diagnosed by Rome Ⅱ criteria.Coping ability and anxiety/depression were assessed by validated questionnaires. Transit time and balloon distension test were performed.RESULTS: 34.5% patients were classified as slow transit type of constipation. The total colonic transit time (56 h vs 10 h, P<0.0001) and rectal sensation including urge sensation (79 mL vs 63 mL, P = 0.019) and maximum tolerable volume (110 mL vs95 mL, P = 0.03) differed in patients and controls. Constipated subjects had significantly higher anxiety and depression scores and lower SF-36 scores in all categories. They also demonstrated higher scores of'monitoring' coping strategy (14+6 vs9+3, P = 0.001),which correlated with the rectal distension sensation (P = 0.005), urge sensation (P=0.002), and maximum tolerable volume (P = 0.035). The less use of blunting strategy predicted slow transit constipation in both univariate (P = 0.01) and multivariate analysis (P = 0.03).CONCLUSION: Defective or ineffective use of coping strategies may be an important etiology in functional constipation and subsequently reflected in abnormal anorectal physiology. | Annie OO Chan Cecilia Cheng Wai Mo Hui Wayne HC Hu Nina YH Wong KF Lam Wai Man Wong Kam Chuen Lai Shiu Kum Lam Benjamin CY Wong | 2005 | World Journal of Gastroenterology2005，11，34： | 92 |
| 2 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy显示文摘Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although there is currently limited evidence to guide the optimal preventive measures, we recommend antiviral prophylaxis in HBs Ag-positive patients receiving novel treatments, especially the Bruton tyrosine kinase inhibitors and the phosphatidylinositol 3-kinase inhibitors, which are B-cell receptor signaling modulators and reduce proliferation of malignant B-cells. Further studies are needed to clarify the risk of HBV reactivation with these agents and the best prophylactic strategy in the era of targeted therapy for hematological malignancies. | Man Fai Law Rita Ho Carmen KM Cheung Lydia HP Tam Karen Ma Kent CY So Bonaventure Ip Jacqueline So Jennifer Lai Joyce Ng Tommy HC Tam | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 3 | Multi-spectral molecular imagi-ng of capillaryendotheliumto facilitate preoperative endovascular br-ain mapping显示文摘 | Manning HC Shay SD Mericle RA | 2009 | J Neurosurg2009，110，5： | 1 |
| 4 | World molecular imaging congress 2015:precision medicine visualized显示文摘 | Manning HC | 2015 | Mol Imaging Biol2015，17，3： | 1 |
| 5 | Translating evidence- based depression management services to commu- nity -based primary care practices 显示文摘 | Kilbourne AM Schulberg HC Post EP Roll- man BL Belnap BH Pincus HA | 2004 | MILBANK QUARTERLY2004，82，4： | 1 |
| 6 | Factors to consider for predictable post and core build-ups of endodonticaUy treatedteeth Part Ⅰ:Basic theoretical concepts显示文摘 | Manning KE Yu DC Yu HC | 1995 | J Can Dent Assoc1995，61，： | 1 |
| 7 | Effect of electric and magnetic fields on plasna control during CO2 laser welding显示文摘 | Tse Man HC Yue HC T M | 1999 | Optics and Lasers in Engineering1999，32，1： | 1 |
| 8 | Cavitation erosion-corrosion characteristics of laser surface modified NiTi shape memory alloy显示文摘 | Cui ZD Man HC Cheng FT | 2003 | Surface Coatings Technology2003，162，23： | 1 |
| 9 | Factors to consider for predicatable post and core build-ups of endodontically treated teeth part: Clinical application of basic concepts 显示文摘 | Manning KE Yu DC Yu HC | 1995 | J Can Dent Assoc1995，61，8： | 1 |
| 10 | Factors to consider for predict- able post and core build-ups of endodontically treated teeth part: clinical application of basic concepts显示文摘 | Manning KE Yu HC Yu HC | 1995 | J Can Dent Assoc1995，61，8： | 1 |
| 11 | Microstructure of laser melted Zn-Al-based alloy显示文摘 | Zhu Y H Man HC Lee WB | 2003 | Journal of Materials Processing Technology2003，139，： | 1 |
| 12 | Magnetic resonance in the era of molecular imaging of caneer显示文摘 | Gore JC Manning HC Quarles CC | 2011 | Magn Reson Imaging2011，29，58： | 1 |
| 13 | A preliminary study of TiO2 deposition on NiTi by a hydrothermal method显示文摘 | Cheng FT Shi P Man HC | | 0，，： | 1 |
| 14 | Simple,high yielding synthesis of trifunctional fluorescent lanthanide chelates显示文摘 | GRIFFIN J M M SKWIERAWSKA A M Manning HC | 2001 | Tetrahedron Letters2001，42，： | 1 |
| 15 | Functional characterization of two ripening related sucrose transporters from grape berries显示文摘 | Manning K Dav ies C Bowen HC White PJ | 2001 | Ann Bot2001，84，： | 1 |
| 16 | Factors to consider for predictable post and core build-ups of endodontically treated teeth Part Ⅰ: basic theoretical concepts显示文摘 | Manning KE Yu DC Yu HC | 1995 | J Can Dent Assoc1995，61，8： | 1 |
| 17 | Functional characterization of two ripening-related sucrose transporters from grape berries显示文摘 | Manning K Davies C Bowen HC | 2001 | Annals of Botany2001，87，： | 1 |
| 18 | Effect of electric and magnetic fields on plasma control during CO2 laser welding显示文摘 | Tse Man HC Yue HC T M | 1999 | Optics and Lasers in Engineering1999，32，1： | 1 |
| 19 | Factors to consider for predictable post and core build -ups of endodontically treated teeth part:Clinical application of basic concepts显示文摘 | Manning KE Yu DC Yu HC | 1995 | J Can Dent Assoc1995，61，8： | 1 |
| 20 | Factors to consider for predictable post and core build-ups of endodontically treated teeth Part Ⅰ:Basic theoretical concepts显示文摘 | Manning KE Yu DC Yu HC | 1995 | J Can Dent Asscor1995，61，： | 1 |
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