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| 1 | Systematic review: Preventive and therapeutic applications of metformin in liver disease显示文摘Metformin, a biguanide derivative, is the most commonly prescribed medication in the treatment of type 2 diabetes mellitus. More recently, the use of metformin has shown potential as a preventive and therapeutic agent for a broad spectrum of conditions, including liver disease and hepatic malignancies. In this systematic review,we critically analyze the literature behind the potential use of metformin across the spectrum of liver disease and malignancies. The Pub Med and Ovid MEDLINE databases were searched from 2000 to March 2015, using a combination of relevant text words and MeS H terms: metformin and mammalian target of rapamycin, hepatitis B virus(HBV), hepatitis B virus(HCV), nonalcoholic fatty liver disease(NAFLD), hepatocellular carcinoma(HCC) or cholangiocarcinoma. The search results were evaluated for pertinence to the issue of metformin in liver disease as well as for quality of study design. Metformin has a number of biochemical effects that would suggest a benefit in treating chronic liver diseases, particularly in the context of insulin resistance and inflammation. However, the literature thus far does not support any independent therapeutic role in NAFLD or HCV. Nonetheless, there is Level Ⅲ evidence for a chemopreventive role in patients with diabetes and chronic liver disease, with decreased incidence of HCC and cholangiocarcinoma. The use of metformin seems to be safe in patients with cirrhosis, and provides a survival benefit. Once hepatic malignancies are already established, metformin does not offer any therapeutic potential. In conclusion, there is insufficient evidence to recommend use of metformin in the adjunctive treatment of chronic liver diseases, including NAFLD and HCV. However, there is good evidence for a chemopreventive role against HCC among patients with diabetes and chronic liver disease, and metformin should be continued in patients even with cirrhosis to provide this benefit. | Aparna Bhat Giada Sebastiani Mamatha Bhat | 2015 | World Journal of Hepatology2015，7，12： | 20 |
| 2 | Implication of the intestinal microbiome in complications of cirrhosis显示文摘The intestinal microbiome(IM) is altered in patients with cirrhosis,and emerging literature suggests that this impacts on the development of complications.The Pub Med database was searched from January 2000 to May 2015 for studies and review articles on the composition,pathophysiologic effects and therapeutic modulation of the IM in cirrhosis.The following combination of relevant text words and MeS H terms were used,namely intestinal microbiome,microbiota,or dysbiosis,and cirrhosis,encephalopathy,spontaneous bacterial peritonitis,hepatorenal syndrome,variceal bleeding,hepatopulmonary syndrome,portopulmonary hypertension and hepatocellular carcinoma.The search results were evaluated for pertinence to the subject of IM and cirrhosis,as well as for quality of study design.The IM in cirrhosis is characterized by a decreased proportion of Bacteroides and Lactobacilli,and an increased proportion of Enterobacteriaceae compared to healthy controls.Except for alcoholic cirrhosis,the composition of the IM in cirrhosis is not affected by the etiology of the liver disease.The percentage of Enterobacteriaceae increases with worsening liver disease severity and decompensation and is associated with bacteremia,spontaneous bacterial peritonitis and hepatic encephalopathy.Lactulose,rifaximin and Lactobacillus-containing probiotics have been shown to partial y reverse the cirrhosis associated enteric dysbiosis,in conjunction with improvement in encephalopathy.The IM is altered in cirrhosis,and this may contribute to the development of complications associated with end-stage liver disease.Therapies such as lactulose,rifaximin and probiotics may,at least partially,reverse the cirrhosisassociated changes in the IM.This,in turn,may prevent or alleviate the severity of complications. | Mamatha Bhat Bianca M Arendt Venkat Bhat Eberhard L Renner Atul Humar Johane P Allard | 2016 | World Journal of Hepatology2016，8，27： | 13 |
| 3 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 4 | Impact of immunosuppression on incidence of post-transplant diabetes mellitus in solid organ transplant recipients:Systematic review and meta-analysis显示文摘BACKGROUND Solid organ transplantation is a life-saving intervention for end-stage organ disease.Post-transplant diabetes mellitus(PTDM)is a common complication in solid organ transplant recipients,and significantly compromises long-term survival beyond a year.AIM To perform a systematic review and meta-analysis to estimate incidence of PTDM and compare the effects of the 3 major immunosuppressants on incidence of PTDM.METHODS Two hundred and six eligible studies identified 75595 patients on Tacrolimus,51242 on Cyclosporine and 3020 on Sirolimus.Random effects meta-analyses was used to calculate incidence.RESULTS Network meta-analysis estimated the overall risk of developing PTDM was higher with tacrolimus(OR=1.495%CI:1.0–2.0)and sirolimus(OR=1.8;95%CI:1.5–2.2)than with Cyclosporine.The overall incidence of PTDM at years 2-3 was 17%for kidney,19%for liver and 22%for heart.The risk factors for PTDM most frequently identified in the primary studies were age,body mass index,hepatitis C,and African American descent.CONCLUSION Tacrolimus tends to exhibit higher diabetogenicity in the short-term(2-3 years post-transplant),whereas sirolimus exhibits higher diabetogenicity in the longterm(5-10 years post-transplant).This study will aid clinicians in recognition of risk factors for PTDM and encourage careful evaluation of the risk/benefit of different immunosuppressant regimens in transplant recipients. | Sreelakshmi Kotha Bishoy Lawendy Saira Asim Charlene Gomes Jeffrey Yu Ani Orchanian-Cheff George Tomlinson Mamatha Bhat | 2021 | World Journal of Transplantation2021，11，10： | 5 |
| 5 | Continuing episodes of pain in recurrent acute pancreatitis: Prospective follow up on a standardised protocol with drugs and pancreatic endotherapy显示文摘AIM To assess the outcomes of drug therapy(DT)followed by pancreatic endotherapy for continuing painful episodes in recurrent acute pancreatitis.METHODS DT comprised of pancreatic enzymes and antioxidants failing which,endotherapy(ET;pancreatic sphincterotomy and stent placement)was done.The frequency of pain,its visual analogue score(VAS),quality of life(Qo L),serum C peptide and faecal elastase were compared between baseline and after 1 year of follow up in all patients and in the two subgroups on DT and ET.Response was defined as at least 50%reduction in the severity of pain to below a score of 5.RESULTS Of the thirty nine patients analysed,21(53.9%)responded to DT and 18(46.1%)underwent ET.The VAS for pain(7.0±2.0 vs 1.3±2.5,P<0.001)and the number of days with pain per month decreased[1.0(1.0,2.0)vs 1.0(0.0,1.0),P<0.001],and the Qo L scores[55.0(44.0,66.0)vs 38.0(32.00,51.00),P<0.01]improved significantly during follow up.Similar significant improvements were seen in patients in the subgroups of DT and ET except for Qo L in ET.The serum C-peptide(P=0.001)and FE(P<0.001)levels improved significantly in the entire group and in the two subgroups of patients except for the C peptide levels in patients on DT.CONCLUSION A standardised protocol of DT,followed by ET decreased the intensity and frequency of pain in recurrent acute pancreatitis,enhanced Qo L and improved pancreatic function. | C Ganesh Pai M Ganesh Kamath Mamatha V Shetty Annamma Kurien | 2017 | World Journal of Gastroenterology2017，23，19： | 2 |
| 6 | Epigenetic basis of hepatocellular carcinoma: A network-based integrative meta-analysis显示文摘AIM To identify the key epigenetically modulated genes and pathways in HCC by performing an integrative meta-analysis of all major, well-annotated and publicly available methylation datasets using tools of network analysis.METHODS Pub Med and Gene Expression Omnibus were searched for genome-wide DNA methylation datasets. Patient clinical and demographic characteristics were obtained. DNA methylation data were integrated using the Ingenuity Pathway Analysis, a software package for visualizing and analyzing biological networks. Pathway enrichment analysis was performed using IPA, which also provides literature-driven and computationallypredicted annotations for significant association of genes to curated molecular pathways.RESULTS From an initial 928 potential abstracts, we identified and analyzed 11 eligible high-throughput methylation datasets representing 354 patients. A significant proportion of studies did not provide concomitant clinical data. In the promoter region, HIST1H2AJ and SPDYA were the most commonly methylated, whereas HRNBP3 gene was the most commonly hypomethylated. ESR1 and ERK were central genes in the principal networks. The pathways most associated with the frequently methylated genes were G-protein coupled receptor and c AMP-mediated signalling. CONCLUSION Using an integrative network-based analysis approach of genome-wide DNA methylation data of both the promoter and body of genes, we identified G-protein coupled receptor signalling as the most highly associated with HCC. This encompasses a diverse range of cancer pathways, such as the PI3 K/Akt/m TOR and Ras/Raf/MAPK pathways, and is therefore supportive of previous literature on gene expression in HCC. However, there are novel targetable genes such as HIST1H2 AJ that are epigenetically modified, suggesting their potential as biomarkers and for therapeutic targeting of the HCC epigenome. | Venkat Bhat Sujitha Srinathan Elisa Pasini Marc Angeli Emily Chen Cristina Baciu Mamatha Bhat | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 7 | Crop and weed discrimination using Laws’ texture masks显示文摘Computers have become an integral part of human lives.Computers are used in almost every field even in agriculture.Technologies like computer vision-based pattern recognition are being used to detect diseases and pests like weeds affecting the crop.The Weeds are unwanted plants growing among crops competing for nutrients,water,and sunlight.It can significantly reduce the quality and yield of the crops incurring a huge loss to the farmers.This paper investigates the use of texture features extracted from Laws’texture masks for discrimination of Carrot crops and weeds in digital images.Laws’texture method is one of the popular methods used to extract texture features in medical image processing,though not much explored in plant-based images or agricultural images.This experiment was carried out on two categories of benchmark digital image datasets of Carrot crop and Carrot weed respectively,which are publicly available.A total of 70 texture features were extracted.The dimensionality reduction technique was used to get the optimal features.These features were then used to train the Random Forest classifier.The results and observations from the experiment showed that the classifier achieved above 94%accuracy. | Radhika Kamath Mamatha Balachandra Srikanth Prabhu | 2020 | International Journal of Agricultural and Biological Engineering2020，13，1： | 2 |
| 8 | Transcriptional induction of the penicillin-banding protein 2 gene in Staphylococcus aureus by cell wall-active antibiotics oxacillin and vancomycin 显示文摘 | Susan B Shaohui Y Mamatha C | 2003 | Antimicrob Agents Chemother2003，47，3： | 1 |
| 9 | Immunohisto- chemical expression of CD34 for characterization and quantifi- cation of mucosal vasculature and its probable role in malignant transformation of atrophic epithelium in oral submucous fibrosis显示文摘 | DESAI RS MAMATHA GS KHATRI MJ | 2010 | Oral Oncol2010，46，9： | 1 |
| 10 | Geochemistry of fluoride rich groundwater in Kolar and Tumkur显示文摘 | Mamatha P Sudhakar M | 2010 | Environmental Earth Sciences2010，61，1： | 1 |
| 11 | The effect of exercise on neuropathic symptoms,nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy显示文摘 | Patricia MK Mamatha P Rupali S | 2012 | J Diabetes Compli- ca2012，26，5： | 1 |
| 12 | Stevens-Johnson Syndrome due to V Ceftriaxone-a case report显示文摘 | Narayanan VS Mamatha GP Ashok L | | 0，，04： | 1 |
| 13 | Comparative evaluation of oral health status of chronic kidney disease (CKD) patients in va-rious stages and healthy controls 显示文摘 | Tadakamadla J Kumar S Mamatha GP | 2014 | Spec Care Dentist2014，34，3： | 1 |
| 14 | Ozonation of the 5-fluorouracil anticancer drug and its prodrug capecitabine:Reaction kinetics,oxidation mechanisms,and residual toxicity显示文摘Anticancer drugs (ADs) have been detected in the environment and represent a risk to aquatic organisms, necessitating AD removal in drinking water and wastewater treatment. In this study, ozonation of the most commonly used antimetabolite ADs, namely 5-fluorouracil (5-FU) and its prodrug capecitabine (CAP), was investigated to determine reaction kinetics, oxidation mechanisms, and residual toxicity. The specific second-order rate constants between aqueous ozone and 5-FU, 5-FU^-, 5-FU^2-, CAP, and CAP^- were determined to be 7.07(±0.11)×10^4 M^-1·s^-1,1.36(±0.06)×10^6 M^-1·s^-1,2.62(±0.17)×10^7M^-1·s^-1,9.69(±0.08)×10^3M^-1·s^-1,and 4.28(±0.07)×10^5M^-1·s^-1, respectively;furthermore, the second-order rate constants for *OH reaction with 5-FU and CAP at pH 7 were determined to be 1.85(±0.20)×10^9 M^-1·s^-1 and 9.95(±0.26)×10^9M^-1·s^-1, respectively. Density functional theory was used to predict the main ozone reaction sites of 5-FU (olefin) and CAP (olefin and deprotonated secondary amine), and these mechanisms were supported by the identified transformation products. Carboxylic acids constituted a majority of the residual organic matter for 5-FU ozonation;however, carboxylic acids and aldehydes were important components of the residual organic matter generated by CAP. Ozone removed the toxicity of 5-FU to Vibriofischeri, but the residual toxicity of ozonated CAP solutions exhibited an initial increase before subsequent removal. Ultimately, these results suggest that ozone is a suitable technology for treatment of 5-FU and CAP, although the residual toxicity of transformation products must be carefully considered. | Siyu Chen Lee Blaney Ping Chen Shanshan Deng Mamatha Hopanna Yixiang Bao Gang Yu | 2019 | Frontiers of Environmental Science & Engineering2019，13，4： | 1 |
| 15 | Production of taxol and its analogues from cell cultures of Taxus wallichiana显示文摘 | Veeresham C Mamatha R Babu C P | 2003 | Pharmaceutical Biology2003，41，6： | 1 |
| 16 | Geochemistry of fluoride rich groundwater in Kolar and Tumkur Districts of Karnataka显示文摘 | Mamatha P Sudhakar M R | 2010 | Environmental Earth Sciences2010，61，1： | 1 |
| 17 | Asymmetric dimethylarginine as a risk marker for early-onset ischemic stroke in indian population显示文摘 | Mamatha SN Nagaraja D Philip M | 2011 | Clin Chim Acta2011，412，12： | 1 |
| 18 | Studies on use of Enteromorpha in snack food显示文摘 | Mamatha B S Namitha K K Senthil A | 2007 | Food Chemistry2007，101，4： | 1 |
| 19 | Geochemistry of fluoride rich groundwater in Kolar and Tumkttr Districts of Karnataka显示文摘 | Mamatha P Sudhakar M R | 2010 | Environmental Earth Sciences2010，61，1： | 1 |
| 20 | Mechanochemical preparation and investigation of properties of magnesium calcium and lithium-magnesium alanates显示文摘 | Mamatha M Bogdanovic B Felderhoff M | 2006 | Journal of Alloys and Compounds2006，407，： | 1 |
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