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| 1 | Dynamic methylome of internal mRNA N^7-methylguanosine and its regulatory role in translation显示文摘Over 150 types of RNA modifications are identified in RNA molecules.Transcriptome profiling is one of the key steps in decoding the epitranscriptomic panorama of these chemical modifications and their potential functions.N7-methylguanosine(m7G)is one of the most abundant modifications present in tRNA,rRNA and mRNA 5’cap,and has critical roles in regulating RNA processing,metabolism and function.Besides its presence at the cap position in mRNAs,m7G is also identified in internal mRNA regions.However,its transcriptome-wide distribution and dynamic regulation within internal mRNA regions remain unknown.Here,we have established m7G individual-nucleotide-resolution cross-linking and immunoprecipitation with sequencing(m7G miCLIP-seq)to specifically detect internal mRNA m7G modification.Using this approach,we revealed that m7G is enriched at the 5’UTR region and AG-rich contexts,a feature that is well-conserved across different human/mouse cell lines and mouse tissues.Strikingly,the internal m7G modification is dynamically regulated under both H2O2 and heat shock treatments,with remarkable accumulations in the CDS and 3’UTR regions,and functions in promoting mRNA translation efficiency.Consistently,a PCAW 3’UTR minigene reporter harboring the native m7G modification site displays both enriched m7G modification and increased mRNA translation upon H2O2 treatment compared to the m7G site-mutated minigene reporter(G to A).Taken together,our findings unravel the dynamic profiles of internal mRNA m7G methylome and highlight m7G as a novel epitranscriptomic marker with regulatory roles in translation. | Lionel Malbec Ting Zhang Yu-Sheng Chen Ying Zhang Bao-Fa Sun Bo-Yang Shi Yong-Liang Zhao Ying Yang Yun-Gui Yang | 2019 | Cell Research2019，29，11： | 17 |
| 2 | Regulation of high-af- finity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors显示文摘 | Dacron M Malbec O Latour S | 1995 | J Clin Invest1995，95，： | 1 |
| 3 | Regulation of Highaffinity IgE Receptor-mediated Mast Cell Activation by Murine Low-affinity IgG Receptors显示文摘 | Dacron M Malbec O Latour S | 1995 | J Clin Invest1995，95，： | 1 |
| 4 | Molecular basis of the recruitment of the SH2 domain-containing inositol 5-phosphatases SHIP1 and SHIP2 by Fc gamma RⅡB 显示文摘 | BRUHNS P VELY F MALBEC O | 2000 | J Biol Chem2000，275，48： | 1 |
| 5 | The mast cell receptors and their roles in tissue inflammation 显示文摘 | Malbec Daeron M | 2007 | Immunol Rev2007，217，20： | 1 |
| 6 | Gastrointestinal tuberculosis: 17 cases collected in 4 hospitals in the northeastern suburb of Paris显示文摘 | Caroline Collado Jér?me Stirnemann Nathalie Ganne Jean-Claude Trinchet Philippe Cruaud Christophe Barrat Joseph Benichou Fran?ois Lhote Denis Malbec Antoine Martin Sophie Prevot Olivier Fain | 2005 | Gastroenterologie Clinique et Biologique2005，，4： | 1 |
| 7 | Negative regulation of mast cell proliferation by FcgammaRIIB显示文摘 | Malbec O Attal JP Fridman WH | 2002 | Mol Immunol2002，8，12： | 1 |
| 8 | Fc episilon receptor Ⅰ -associated lyn-dependent phasphorlation of Fc gamma receptor Ⅱ B during negative regulation of mast cell activation显示文摘 | Fong DC Turner M | 1998 | J Immunol1998，160，4： | 1 |
| 9 | Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors显示文摘 | Daeron M Malbec O Latour S | 1995 | J Clin Invest1995，95，： | 1 |
| 10 | The mast cell IgG receptors and their roles in tissue inflammation显示文摘 | Malbec O Daeron M | 2007 | Immunol Rev2007，217，： | 1 |
| 11 | Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgGreceptors显示文摘 | DARON M MALBEC O LATOUR S | 1995 | J Clin Invest1995，95，： | 1 |
| 12 | The mast cell IgG receptors and their roles in tissue inflammation显示文摘 | Malbec O Daeron M | 2007 | Immunol Rev2007，217，： | 1 |
| 13 | Fce receptor Ⅰ associated lyn-dependent phosphorylation of Fc γ receptor ⅡB during negative regulation of mast cell activation显示文摘 | Malbec O Fang DC Turner M | 1998 | J Immunol1998，160，4： | 1 |
| 14 | Signal regulatory proteins negatively regulate immunoreceptor-dependent cell activation显示文摘 | Lienard H Bruhns P Malbec O | 1999 | J Biol Chem1999，274，32： | 1 |
| 15 | Fe episilon receptor I-assoiated tyn-dependent phasportation of Fc gamma receptor B during negative regutation of mast celt activation 显示文摘 | Malbec F Fong DG Tuner M | 1998 | J Immunot1998，160，： | 1 |
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