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| 1 | The cartilage matrisome in adolescent idiopathic scoliosis显示文摘The human spinal column is a dynamic,segmented,bony,and cartilaginous structure that protects the neurologic system and simultaneously provides balance and flexibility.Children with developmental disorders that affect the patterning or shape of the spine can be at risk of neurologic and other physiologic dysfunctions.The most common developmental disorder of the spine is scoliosis,a lateral deformity in the shape of the spinal column.Scoliosis may be part of the clinical spectrum that is observed in many developmental disorders,but typically presents as an isolated symptom in otherwise healthy adolescent children.Adolescent idiopathic scoliosis(AIS)has defied understanding in part due to its genetic complexity.Breakthroughs have come from recent genome-wide association studies(GWAS)and next generation sequencing(NGS)of human AIS cohorts,as well as investigations of animal models.These studies have identified genetic associations with determinants of cartilage biogenesis and development of the intervertebral disc(IVD).Current evidence suggests that a fraction of AIS cases may arise from variation in factors involved in the structural integrity and homeostasis of the cartilaginous extracellular matrix(ECM).Here,we review the development of the spine and spinal cartilages,the composition of the cartilage ECM,the so-called'matrisome'and its functions,and the players involved in the genetic architecture of AIS.We also propose a molecular model by which the cartilage matrisome of the IVD contributes to AIS susceptibility. | Carol AWise Diane Sepich Aki Ushiki Anas MKhanshour Yared HKidane Nadja Makki Christina AGurnett Ryan SGray Jonathan JRios Nadav Ahituv Lila Solnica-Krezel | 2020 | Bone Research2020，8，1： | 5 |
| 2 | Evidence of adverse selection in crop insurance markets显示文摘 | Makki S S Somwaru A | 2001 | Journal of Risk and Insurance2001，68，4： | 1 |
| 3 | The epidermal growth fac- tor receptor and its ligands in cardiovascular disease 显示文摘 | Makki N Thiel KW Miller FJ Jr | 2013 | Int J Mol Sci2013，14，20： | 1 |
| 4 | Osteosynthesis of displaced intra-articular fractures of the calcaneum:a long-term review of 47cases显示文摘 | Makki D Alnajjar HM Walkay S | 2010 | J Bone Joint Surg Br2010，92，5： | 1 |
| 5 | Sensornetwork security : a survey 显示文摘 | CHEN Xiangqian Makki Kia YEN Kang | 2009 | IEEE Communications Surveys and Tutorials2009，11，2： | 1 |
| 6 | The epidermal growth factor receptor and its ligands in cardiovascular disease 显示文摘 | Makki N Thiel KW Miller FJ Jr | 2013 | Int J Mol Sci2013，14，20： | 1 |
| 7 | Mode shaping of a graded-reflectivitymirror unstable resonator with an intra-cavity phase element显示文摘 | MAKKI S LEGER J | 2001 | IEEE Journal of Quantum Electronics2001，37，1： | 1 |
| 8 | Collaborative Trust-based Secure Routing in Multihop Ad Hoc Networks显示文摘 | Pissinou N Ghosh T Makki K | 2004 | Lecture Notes in Computer Science2004，3042，11： | 1 |
| 9 | Characterizing iron deposition in multiple sclerosis lesions using susceptibility-weighted imagin显示文摘 | Haacke EM Makki M Ge Y | 2009 | Journal of Magnetic Resonance Imaging2009，29，3： | 1 |
| 10 | Diabetes control with recipro-cal peer support versus nurse care management : a randomized trial显示文摘 | Heisler M Vijan S Makki F | 2010 | Ann Intern Med2010，153，8： | 1 |
| 11 | Increased arterial distensibility induced by the angiotensin-converting enzyme inhibitor,lisinopril,in normotensive rats显示文摘 | Makki T Talom RT Niederhoffer N | | 0，，02： | 1 |
| 12 | Differentiating reactive mesothelial ceils from metastatic adenocarcinoma in serous effusions: the utility of immunocytochemical panel in the differential diagnosis 显示文摘 | Saleh HA E1-Fakharany M Makki H | 2009 | Diagn Cytopathol2009，37，5： | 1 |
| 13 | Lateral ectopicthyroid goiter with a normally located thyroid显示文摘 | Amoodi H A Makki F Taylor M | 2010 | Thyroid2010，20，2： | 1 |
| 14 | Lateral ectopic thyroid goiter with a normally located thyroid 显示文摘 | Amoodi H A Makki F Taylor M | 2010 | Thyroid2010，20，： | 1 |
| 15 | Overexpression ofβ-catenin and cyclin D1 predicts a poor prognosis in ovarian serous carcinomas显示文摘 | Wang H Wang HY Makki MS | 2014 | Int JClin Exp Pathol2014，7，1： | 1 |
| 16 | Characterizing iron deposi-tion in multiple sclerosis lesions using susceptibility weightedimaging显示文摘 | Haacke EM Makki M Ge Y | 2009 | j Magn Reson Imaging2009，29，3： | 1 |
| 17 | Transient power supply current monitoring--A new test method for CMOS VLS! circuits显示文摘 | Su S T Makki R Z Nagle T | 1995 | Journal of Electronic Testing:Theory and Applications1995，6，1： | 1 |
| 18 | Membrane transport proteins associated with drug resistance expressed in human melanoma显示文摘 | Schadendorf D Makki A Stahr C van Dyck A Wanner R Scheffer GL | 1995 | Am J Pathol1995，147，： | 1 |
| 19 | Sensor Network Securi- ty: A Survey 显示文摘 | Chen Xiangqian Makki K Yen Kang | 2009 | IEEE Communications Surveys & Tutorials2009，11，2： | 1 |
| 20 | Lateral ectopic thyroid goiter with a normally located thyroid显示文摘 | AMOODI H A MAKKI F TAYLOR M | 2010 | Thyroid2010，20，： | 1 |
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