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| 1 | Genetic mechanisms underlying the pathogenesis of tropical calcific pancreatitis显示文摘Chronic pancreatitis is known to be a heterogeneous disease with varied etiologies.Tropical calcific pancreatitis(TCP) is a severe form of chronic pancreatitis unique to developing countries.With growing evidence of genetic factors contributing to the pathogenesis of TCP,this review is aimed at compiling the available information in this field.We also propose a two hit model to explain the sequence of events in the pathogenesis of TCP. | Swapna Mahurkar D Nageshwar Reddy G Venkat Rao Giriraj Ratan Chandak | 2009 | World Journal of Gastroenterology2009，15，3： | 4 |
| 2 | Comprehensive screening for reg1α gene rules out association with tropical calcific pancreatitis显示文摘AIM: To investigate the allelic and haplotypic association of reg1α gene with tropical calcific pancreatitis (TCP). Since TCP is known to have a variable genetic basis, we investigated the interaction between mutations in the susceptibility genes, SPINK1 and CTSB with reg1α polymorphisms. METHODS: We analyzed the polymorphisms in the reg1α gene by sequencing the gene including its promoter region in 195 TCP patients and 150 ethnically matched controls, compared their allele and haplotype frequencies, and their association with the pathogenesis and pancreaticolithiasis in TCP and fibro-calculous pancreatic diabetes. RESULTS: We found 8 reported and 2 novel polymo-rphisms including an insertion-deletion polymorphism in the promoter region of reg1α. None of the 5' UTR variants altered any known transcription factor binding sites, neither did any show a statistically significant association with TCP. No association with any reg1α variants was observed on dichotomization of patients based on their N34S SPINK1 or L26V CTSB status. CONCLUSION: Polymorphisms in reg1α gene, including the regulatory variants singly or in combination with the known mutations in SPINK1 and/or CTSB genes, are not associated with tropical calcific pancreatitis. | Swapna Mahurkar Seema Bhaskar D Nageshwar Reddy G Venkat Rao Giriraj Ratan Chandak | 2007 | World Journal of Gastroenterology2007，13，44： | 3 |
| 3 | Lack of significant association of an insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene with tropical calcific pancreatitis显示文摘 | Bhaskar S Reddy DN Mahurkar S | 2006 | BMC Gastroenterol2006，6，： | 1 |
| 4 | Relatonship of posture and age to urinary protein excretion 显示文摘 | Mahurkar SD Dunea G Pillay VK | 1975 | BMJ1975，1，： | 1 |
| 5 | The G191R variant in the PRSS2 gene does not play a role in protection against tropical calcifie panereatitis显示文摘 | Mahurkar S Bhaskar S Reddy DN | 2009 | Gut2009，58，： | 1 |
| 6 | Association of cathepsin Bgene polymorphisms with tropical calcific pancreatitis显示文摘 | Mahurkar S Idris MM Reddy DN | | 0，，： | 1 |
| 7 | Hepatic cho- lesterol tra- nsporter ABCG8 polymorphisms in gallstone disease in an Indian population 显示文摘 | Siddapuram SP Mahurkar S Duwuru NR | 2010 | Gastroenterol Hepatol2010，25，6： | 1 |
| 8 | Common variants in NOD2 and IL23R are not associated with inflammatory bowel disease in Indians显示文摘 | Mahurkar S Banerjee R Rani VS | | 0，，： | 1 |
| 9 | Subcutaneousadipose tissue macrophge infiltration is associated with hepaticand visceral fat deposition, hyperinsulinemia, and stimulationof NK-kappaB stress pathway 显示文摘 | Le KA Mahurkar S Alderete TL | 2011 | Diabetes2011，60，11： | 1 |
| 10 | Subcutaneous adipose tissue macrophage infiltration is associated with hepatic and visceral fat deposi- tion, hyperinsulinemia, and stimulation of NF-KB stress pathway 显示文摘 | L~ KA Mahurkar S Alderete TL | 2011 | Diabetes2011，60，11： | 1 |
| 11 | Subcutaneous adipose tissue macrophage infiltration is associated with hepatic and visceral fat deposition, hyperinsulinemia, and stimulation of NF-κB stress pathway显示文摘 | Lê KA Mahurkar S Alderete TL | 2011 | Diabetes2011，60，11： | 1 |
| 12 | Subcutaneous adipose tissue macrophage infiltration is associated with hepatic and visceral fat deposition,hyperinsulinemia,and stimulation of NF-κB stress pathway显示文摘 | Le KA Mahurkar S Alderete TL | | 0，，11： | 1 |
| 13 | Phytochemical analysis and antifertility potential of Cynodon dactylon in female Wistar rats:A herbal approach towards contraception显示文摘Objective:The objective of the present study was to evaluate the antifertility activity of ether(ErCD),chloroform(CeCD)and ethyl alcohol(EyCD)extracts of the whole plant of Cynodon dactylon in female Wistar albino rats.Methods:Acute oral toxicity and an antifertility study were performed in female Wistar rats with two dose levels(200 and 400 mg/kg,orally)of EyCD.The estrogenic and progestogenic effects of EyCD were further observed by administering it to immature Wistar rats by investigations of vaginal cornification,hormonal level,uterus weight,biochemical parameters,histopathology of the uterus and deciduoma formation,respectively.Isolation of EyCD was carried out by Flash Chromatography and isolated fraction was estimated by HPLC.Results:No toxicity with any of the extract was found up to the dose of 2000 mg/kg body weight.EyCD treated rats exhibited maximum reduction in pregnancy(83.33%).Estimation of EyCD on vaginal cornification,estrogen-induced uterotrophic assay and deciduoma model demonstrated vaginal cornification,significant(P<0.01)increase in uterine weight and uterine proliferation in histopathology and reduced deciduoma formation respectively.Hormonal and biochemical parameters confirmed the above findings indicating estrogenic potential and antiprogestogenic potential of EyCD that might be attributed to the presence of phytoestrogen(apigenin)in EyCD.Conclusion:The results suggested that extracts of C.dactylon possess significant antifertility activity,which is consistent with the literature reported in folk medicine of this plant in fertility regulation. | Arati Malpani Nitin Mahurkar Urmila Aswar | 2020 | Chinese Herbal Medicines2020，12，3： | 0 |
| 14 | Sterols possess immunomodulatory property:Activity guided isolation and in vitro screening of phytoconstituents of Pongamia glabra and Ficus glomerata显示文摘Objective:To isolate the phytoconstituents from the methanolic extracts of the stem bark of Pongamia glabra and Ficus glomerata,characterize spectroscopically and screen for in vitro immunomodulatory activity on human neurophils.Methods:A flavonoid(PGF)and an alkaloidal compound(PGA)from the extract of P.glabra and a steroidal compound(FGS)and tannin fraction(FGT)from the extract of F.glomerata were isolated using column chromatography technique and were subjected for the spectroscopic(FT-IR,1HNMR and LC-MS)and TLC studies to identify the compounds.The isolated compounds were screened for in vitro immunomodulatory activity on human neutrophils using nitroblue tetrazolium(NBT)dye test,phagocytosis of Candida albicans and neutrophil locomotion and chemotaxis assay at the concentration range of 100,50,25,12.50 and 5.00μg/mL.Results:From the spectroscopic and TLC studies data,the isolated compounds were identified as glabrin(PGA),karanjin(PGF),β-sitosterol(FGS),and tannin fraction(FGT).The isolated compounds PGA,PGF,FGS,and FGT exhibited significant(P<0.05)in vitro immunomodulatory activity in all the parameters studied.Conclusion:The steroidal compound,i.e.FGS was found to be more immunopotent than all constituents alkaloid,flavonoid and tannins.Hence,these constituents could be attributed to the immunomodulatory property of the plants. | Sanjeev Heroor Arunkumar Beknal Nitin Mahurkar Suresh Hiremath Shivkumar Inamdar | 2020 | Chinese Herbal Medicines2020，12，3： | 0 |
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