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| 1 | 1α,25-dihydroxyvitamin D_(3) prevents DNA damage and restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine and promoted by phenobarbital显示文摘AIM:To investigate the chemopreventive iffects of 1α,25-dihydroxyvitamin D3 in diethylnitrosamine induced,phenobarbital promoted rat hepatocarcinogenesis.METHODS:The rats were randomly divided into 6 different groups(A-F).Group A,C and E rats received a single intraperitoneal (i.p) injection of diethylnitrosamine (DEN) at a dose of 200 mg/kg body mass in 9 g/L NaCl solution at 4 wk of age ,while group B served as normal vehicle control received normal saline once.After a brief recovery of 2 WK, all the DEN treated rats were given phenobarbital (PB) at 0.5g/L daily in the basal diet till WK 20.Group C was started 4 wk prior to DEN injection and continued thereafter till wk 20 at a dose (os) twice a week.Group E received the treatment of 1α,25-(OH)2D3 at the same dose mentioned as above for 15 wk.The rats in group D and F received 1α,25-(OH)2D3 alone as in group C without DEN injection.RESULTS:The comet assay showed statistically higher mean values for length to width ratios (L:W) of DNA mass and tailed cells (p<0.01;p<0.01 respectively) in DEN treated rats as compared to their normal controls.Continuous supplementation of 1α,25-dihydroxyvitaminD3 showed a significant (p<0.01) decrease in L:W ratio of DNA mass tailed cells.Furthermore,1α,25-(OH)2D3 supplementations elevated the super oxide dismutase (SOD) activety,hepatic malondialdehyde(MDA) levle,reduced glutathione (GSH) and glutathione S-transferase (GST) activety (p<0.01,p<0.01,p<0.05 and p<0.05 respectively).As an endpoint marker histological changes were observed to establish the chemopreventive effects of 1α,25-dihydroxyvitaminD3.CONCLUSION:Supplementations of 1α,25-(OH)2D3 has a marked protection against hepatic nodelogenesis,antioxidant enzymes and DNA damages in DEN induced rat hepatocarcinogenesis promoted by phenobarbital. | Mahendrakumar Chandrasekharappa Banakar Suresh Kanna Paramasivan Mitali Basu Chattopadhyay Subrata Datta Prabir Chakraborty Malay Chatterjee Kalaiselvi Kannan Elayaraja Thygarajan | 2004 | World Journal of Gastroenterology2004，10，9： | 5 |
| 2 | Design of an aluminium- based vehicle platform for front impact safety 显示文摘 | Deb A Mahendrakumar M S Chavan C | 2004 | International Journal of Impact Engineering2004，30，89： | 1 |
| 3 | Microencapsulation of microbial cells 显示文摘 | Sweta Rathore Parind Mahendrakumar Desai Celine Valeria Liew | 2013 | Journal of Food Engineering2013，116，2： | 1 |
| 4 | Microencapsulation of microbial cells显示文摘 | Sweta Rathore Parind Mahendrakumar Desai Celine Valeria | 2013 | Journal of Food Engineering2013，116，2： | 1 |
| 5 | Design of an aluminium-based vehicle platform for front impact safety显示文摘 | Deb A Mahendrakumar M S | 2004 | International Journal of Impact Engineering2004，30，： | 1 |
| 6 | Predictors for moderate to severe acute postoperative pain after total hip and knee replacement显示文摘 | Spencer S. Liu Asokumar Buvanendran James P. Rathmell Mona Sawhney James J. Bae Mario Moric Stephen Perros Ashley J. Pope Lazaros Poultsides Craig J. Della Valle Naomi S. Shin Colin J. L. McCartney Yan Ma Mahendrakumar Shah Monica J. Wood Smith C. Manion | 2012 | International Orthopaedics2012，，11： | 1 |
| 7 | Design of an Aluminium Based Vehicle Platform for Front Impact Safety 显示文摘 | Deh A Mahendrakumar M S Chavan C | 2004 | International Journal of Impact Engineering2004，30，89： | 1 |
| 8 | Design of an aluminium-base vehicle platform for front impact safety显示文摘 | DEB A MAHENDRAKUMAR M S CHAVAN C | 2004 | International Journal of Impact Engineering2004，30，1： | 1 |
| 9 | Effect of vanadium on colonic aberrant crypt loci induced in rats by 1,2 Dimethyl hydrazine显示文摘AIM: To investigate the chemo preventive effects of vanadium on rat colorectal carcinogenesis induced by 1,2-dimethylhydrazine (DMH).METHODS: Male Sprague-Dawley Rats were randomly divided into four groups. Rats in Group A received saline vehicle alone for 16 weeks. Rats in Group B were given DMH injection once a week intraperitoneally for 16 weeks;rats in Group C, with the same DMH treatment as in the Group B, but received 0.5-ppm vanadium in the form ammonium monovanadate ad libitum in drinking water. Rats in the Group D received vanadium alone as in the Group C without DMH injection.RESULTS: Aberrant crypt foci (ACF) were formed in animals in DMH-treated groups at the end of week 16.Compared to DMH group, vanadium treated group had less ACF (P<0.001). At the end of week 32, all rats in DMH group developed large intestinal tumors. Rats treated with vanadium contained significantly few colonic adenomas and carcinomas (P<0.05) compared to rats administered DMH only. In addition, a significant reduction (P<0.05) in colon tumor burden (sum of tumor sizes per animal) was also evident in animals of Group C when compared to those in rats of carcinogen control Group B. The results also showed that vanadium significantly lowered PCNA index in ACF (P<0.005). Furthermore, vanadium supplementation also elevated liver GST and Cyt P-450 activities (P<0.001 and P<0.02, respectively).CONCLUSION: Vanadium in the form of ammonium monovanadate supplemented in drinking water ad libitum has been found to be highly effective in reducing tumor incidence and preneoplastic foci on DMH-induced colorectal carcinogenesis. These findings suggest that vanadium administration can suppress colon carcinogenesis in rats. | PSuresh Kanna CB Mahendrakumar T Chakraborty P Hemalatha Pratik Banerjee M Chatterjee | 2003 | World Journal of Gastroenterology2003，9，5： | 1 |
| 10 | Microencapsulation of microbial cells显示文摘 | Sweta Rathore Parind Mahendrakumar Desai Celine Valeria Liew | 2013 | Journal of Food Engineering2013，116，2： | 1 |
| 11 | Reinforcement Learning to Improve QoS and Minimizing Delay in IoT显示文摘Machine Learning concepts have raised executions in all knowledge domains,including the Internet of Thing(IoT)and several business domains.Quality of Service(QoS)has become an important problem in IoT surrounding since there is a vast explosion of connecting sensors,information and usage.Sen-sor data gathering is an efficient solution to collect information from spatially dis-seminated IoT nodes.Reinforcement Learning Mechanism to improve the QoS(RLMQ)and use a Mobile Sink(MS)to minimize the delay in the wireless IoT s proposed in this paper.Here,we use machine learning concepts like Rein-forcement Learning(RL)to improve the QoS and energy efficiency in the Wire-less Sensor Network(WSN).The MS collects the data from the Cluster Head(CH),and the RL incentive values select CH.The incentives value is computed by the QoS parameters such as minimum energy utilization,minimum bandwidth utilization,minimum hop count,and minimum time delay.The MS is used to col-lect the data from CH,thus minimizing the network delay.The sleep and awake scheduling is used for minimizing the CH dead in the WSN.This work is simu-lated,and the results show that the RLMQ scheme performs better than the base-line protocol.Results prove that RLMQ increased the residual energy,throughput and minimized the network delay in the WSN. | Mahendrakumar Subramaniam V.Vedanarayanan Azath Mubarakali S.Sathiya Priya | 2023 | Intelligent Automation & Soft Computing2023，，5： | 0 |
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