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| 1 | Protective effect of essential oil of Pistacia atlantica Desf. on peptic ulcer: role of α-pinene显示文摘OBJECTIVE: To evaluate the efficacy of Pistacia atlantica Desf. oleoresin essential oil on peptic ulcer(PU) and its antibacterial effect on metronidazole-resistant Helicobacter pylori, as well as chemi-cal composition of the essential oil.METHODS: The essential oil was standardized using gas chromatography mass spectrometry(GC/MS) analysis. Acute toxicity of the essential oil was assessed in animal model. In vitro anti-Helicobacter pylori activity was performed through disc diffusion and minimum inhibitory concentration method. For gastroprotective assay, rats received Pistacia atlantica Desf. essential oil(25, 50 and 100 mg/kg orally) 1 h before induction of ulcer by ethanol.Macroscopic(ulcer index and protection rate) and microscopic examination were performed.RESULTS: The GC/MS analysis of the essential oil led to the identification of twenty constituents andα-pinene is predominant constituent. The essential oil was safe up to 2000 mg/kg. All Helicobacter pylori strains were susceptible to the essential oil and the MIC ranged from 275 to 1100 μg/m L. The ulcer index for treated groups was significantly reduced compared to control(P < 0.001) with EC50 value of 12.32 mg/kg. In microscopic examination, Pistacia atlantica attenuated destruction and necrosis of gastric tissue.CONCLUSION: Current study exhibited protective effect of standardized Pistacia atlantica essential oil against ethanol-induced gastric ulcer and its antibacterial activity on Helicobacter pylori. α-pinene might be the responsible agent. | Zahra Memariani Mohammad Sharifzadeh Mahbubeh Bozorgi Mannan Hajimahmoodi Mohammad Hosein Farzaei Mahdi Gholami Farideh Siavoshi Parastoo Saniee | 2017 | Journal of Traditional Chinese Medicine2017，37，1： | 10 |
| 2 | Efficacy and safety of Amla(Phyllanthus emblica L.) in non-erosive reflux disease:a double-blind,randomized,placebo-controlled clinical trial显示文摘Background: Gastroesophageal reflux disease(GERD) is one of the most common gastrointestinal complaints. GERD, caused by the reflux of stomach contents into the esophagus, leads to troublesome symptoms such as heartburn and regurgitation. It is classified into two types: erosive esophagitis,characterized by visible esophageal mucosa erosion in endoscopy, and non-erosive reflux disease(NERD). GERD is a chronic and recurrent disease that impairs the quality of life and imposes socioeconomic and therapeutic burdens to both patients and society.Objective: Due to the failure of the conventional treatments for GERD and to the traditional use of Amla(Phyllanthus emblica L.), in addition to beneficial effects shown in recent studies, we evaluated the safety and efficacy of Amla tablet for improvement of symptoms of patients with NERD.Design, setting, participants and interventions: We designed a double-arm, randomized, double-blind,placebo-controlled clinical trial. Sixty-eight patients who had classic symptoms of GERD(heartburn,regurgitation and epigastralgia) for at least three months before the start of the trial were randomized in two parallel groups. Patients in the Amla group received two 500 mg Amla tablets twice a day, after meals,for 4 weeks. In the control group, patients received placebo tablets similar to the Amla prescription.Main outcome measures: The patients were visited at baseline, and at the end of the 2 nd and 4 th weeks of intervention; their symptoms were measured on a frequency and severity scale for the symptoms of NERD,according to the quality of life in reflux-associated disease questionnaire.Results: Frequencies of heartburn and regurgitation in both groups of the study were significantly reduced after intervention(P < 0.001). Repeated measures logistic regression analysis showed that, in the Amla group, there was a more significant reduction in regurgitation frequency, heartburn frequency, regurgitation severity and heartburn severity during the study period, compared with the placebo group(P < 0.001).Conclusion: This randomized double-blind, placebo-controlled clinical trial demonstrated that Amla could reduce frequencies of heartburn and regurgitation and improve heartburn and regurgitation severity in patients with NERD. | Shahnaz Karkon Varnosfaderani Fataneh Hashem-Dabaghian Gholamreza Amin Mahbubeh Bozorgi Ghazaleh Heydarirad Esmaeil Nazem Mohsen Nasiri Toosi Seyed Hamdollah Mosavat | 2018 | Journal of Integrative Medicine2018，16，2： | 7 |
| 3 | A Potential Association between Helicobacter pylori CagA EPIYA and Multimerization Motifs with Cytokeratin 18 Cleavage Rate during Early Apoptosis显示文摘 | Samaneh Saberi Masoumeh Douraghi Kayhan Azadmanesh Mohammad Ali Shokrgozar Hojjat Zeraati Mahmoud Eshagh Hosseini Mohammad Ali Mohagheghi Mahbubeh Parsaeian Marjan Mohammadi | 2012 | Helicobacter2012，，5： | 1 |
| 4 | Traditional medical uses of Drimia species in terms of phytochemistry,pharmacology and toxicology显示文摘Drimia genus includes plants that used from ancient time for various ailments such as dropsy, respiratory ailment, bone and joint complications,skin disorders, epilepsy and cancer. Toxic properties of some Drimia species also were noted by ancient scientists and these plants have been traditionally used for rat control. Bufadienolides have been identified as the main constituents in the genus of Drimia. Phenolics, sterols, protein and some of other phytochemicals have been also isolated from these plants. Pharmacological and clinical studies have strongly approved their effect on cardiovascular system. Extracts and compounds isolated from Drimia species showed biological activities such as antibacterial, antifungal, antiviral, antioxidant, anti-inflammatory and insecticidal effects throughseveral in vivo and in vitro studies. Moreover, cytotoxic and antitumor activities which may be related to bufadienolide content of these plants have been considered by many researchers. Traditional therapeutic values of these plants for treating respiratory and rheumatic ailments as well as skin disorders are needed to be validated through more researches. Toxic effects of these plants and isolated compounds have been investigated through several in vivo studies. Drimia plants and their isolated compounds have narrow therapeutic index, so patients should be prohibited from applying these plants without medical supervision and should be informed about the main intoxication symptoms before starting treatment. Moreover, interaction of Drimia plants with other constituents of traditional herbal mixtures as well as chemical and biological modalities for reducing toxicity of bufadienolide compounds can be subjected for future studies. | Mahbubeh Bozorgi Gholamreza Amin Maryam Shekarchi Roja Rahimi | 2017 | Journal of Traditional Chinese Medicine2017，37，1： | 1 |
| 5 | Mechanical properties and antibacterial activities of novel nano biocomposite films of chitosan and starch显示文摘 | ZAHRA SHARIATINIA MAHBUBEH FAZLI | 2015 | Food Hydrocolloids2015，，46： | 1 |
| 6 | On the mechanical aspect of additive manufactured polyether-ether-ketone scaffold for repair of large bone defects显示文摘Polyether-ether-ketone(PEEK)is widely used in producing prosthesis and have gained great attention for repair of large bone defect in recent years with the development of additive manufacturing.This is due to its excellent biocompatibility,good heat and chemical stability and similar mechanical properties which mimics natural bone.In this study,three replicates of rectilinear scaffolds were designed for compression,tension,three-point bending and torsion test with unit cell size of 0.8 mm,a pore size of 0.4 mm,strut thickness of 0.4 mm and nominal porosity of 50%.Stress-strain graphs were developed from experimental and finite element analysis models.Experimental Young’s modulus and yield strength of the scaffolds were measured from the slop of the stress-strain graph to be 395 and 19.50 MPa respectively for compression,427 and 6.96 MPa respectively for tension,257 and 25.30 MPa respectively for three-point bending and 231 and 12.83 MPa respectively for torsion test.The finite element model was found to be in good agreement with the experimental results.Ductile fracture of the struct subjected to tensile strain was the main failure mode of the PEEK scaffold,which stems from the low crystallinity of additive manufacturing PEEK.The mechanical properties of porous PEEK are close to those of cancellous bone and thus are expected to be used in additive manufacturing PEEK bone implants in the future,but the lower yield strength poses a design challenge. | Seyed Ataollah Naghavi Changning Sun Mahbubeh Hejazi Maryam Tamaddon Jibao Zheng Leilei Wang Chenrui Zhang Swastina Nath Varma Dichen Li Mehran Moazen Ling Wang Chaozong Liu | 2022 | Biomaterials Translational2022，3，2： | 0 |
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