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| 1 | Unexpected metastasis of intraductal papillary neoplasm of the bile duct without an invasive component to the brain and lungs:A case report显示文摘BACKGROUND Despite an expanding number of studies on intraductal papillary neoplasm of the bile duct(IPNB),distant metastasis remains unexplained especially in cases of carcinoma in situ.In the present study,we report a rare and interesting case of IPNB without invasive components that later metastasized to lungs and brain.CASE SUMMARY A 69-year-old male was referred to our hospital due to suspected cholangiocarcinoma.Laboratory tests on admission reported a mild elevation of alkaline phosphatase,γ-glutamyl transpeptidase,and total bilirubin in serum.Endoscopic retrograde cholangiography revealed a filling defect in the common bile duct(CBD)extending to the left hepatic duct.Peroral cholangioscopy delineated a tumor in the CBD that had a papillary pattern.Multidetector computed tomography and magnetic resonance cholangiopancreatography detected partial blockage ot interlude in the CBD leading to cholestasis without evidence of metastasis.Therefore,a diagnosis of IPNB cT1N0M0 was established.Left hepatectomy with bile duct reconstruction was performed.Pathological examination confirmed an intraepithelial neoplasia pattern without an invasive component and an R0 resection achievement.The patient was monitored carefully by regular examinations.However,at 32 mo after the operation,a 26 mm tumor in the lungs and a 12 mm lesion in the brain were detected following a suspicious elevated CA 19-9 level.Video-assisted thoracoscopic surgery of left upper lobectomy and stereotactic radiotherapy are indicated.In addition to histopathological results,a genomic profiling analysis using whole exome sequencing subsequently confirmed lung metastasis originating from bile duct cancer.CONCLUSION This case highlights the important role of genomic profiling analysis using whole exome sequencing in identifying the origin of metastasis in patients with IPNB. | Nguyen Hai Nam Kojiro Taura Masashi Kanai Keita Fukuyama Norimitsu Uza Hirona Maeda Yojiro Yutaka Toyofumi F Chen-Yoshikawa Manabu Muto Shinji Uemoto | 2020 | World Journal of Gastroenterology2020，26，3： | 5 |
| 2 | Interindividual variability of the modulatoy effects of repetitive transcranial magnetic stimulation on cortical excitability显示文摘 | Maeda F Keenan IP Tormos IM | 2000 | Exp Brain Res2000，131，： | 1 |
| 3 | Aggravation of brain injury after transient focal ischemia in p53-deficient mice显示文摘 | Maeda K Hata R Gillardon F Hossmann KA | 2001 | Mol Brain Res2001，88，12： | 1 |
| 4 | Inhibition of vitronectinmediated haptotaxis and haptoinvasion of MG-63 cells by domain 5(D5H) of human high-molecular-weight kininogen and identification of a minimal amino acid sequence显示文摘 | Kamiyama F Maeda T Yamane T | 2001 | Biochem Biophys Res Commun2001，288，4： | 1 |
| 5 | Synthesis and antimicrobial characteristics of novel antimicrobial agent,1,4-dialkyl-1,4 -dihydroxyethylpiperadinium diiodides immobilized on inorganic materials显示文摘 | ZHOU F MAEDA T NAGAMUNE H | 2003 | Biocontrol Science2003，8，4： | 1 |
| 6 | Effect of post-treatments on the photocatalytic activity of SmzTi2S2O5 for the hydrogen evolution reaction显示文摘 | Zhao W Maeda K Zhang F | 2014 | Physical Chemistry ChemicalPhysics2014，16，12： | 1 |
| 7 | Glucosyldiacylglycerol enhances reciprocal activation of prourokinase and plasminogen显示文摘 | WU W NARASAKI R MAEDA F | 2004 | Biosci Biotechnol Biochem2004，68，7： | 1 |
| 8 | Synthesis and antimicrobial characteristics of novel biocides,1,1'-(decanedioyl) bis (4-methyl-4-alkylpiperazinium iodide) s with gemini structure显示文摘 | ZHOU F MAEDA T NAGAMUNE H | 2004 | Biocontrol Science2004，9，3： | 1 |
| 9 | Inducible expression of a foreign gene inserted into the human cytomegalovirus genome显示文摘 | TAKEOSHI M MAEDA F IHARA S | 1993 | J Gen Virol1993，74，8： | 1 |
| 10 | Accelerated learning curve for colorectal resection, open versus laparoscopic approach, can he attained with expert supervision 显示文摘 | Maeda T Tan KY Konishi F | 2010 | Surg Endosc2010，24，11： | 1 |
| 11 | Biological activity of He- licobacter pylori components in mammalian ceils: is it independent of proteinase-activated receptors? 显示文摘 | Sekiguchi F Matsumoto Y Maeda Y | 2012 | J Physiol Pharmacol2012，63，： | 1 |
| 12 | Helicobacter pylori antigen in the glomeruli of patients with membranous nephropathy显示文摘 | Nagashima R Maeda K Yuda F | 1997 | Virchows Arch1997，431，： | 1 |
| 13 | Yield function development for aluminum alloy sheets显示文摘 | BARLAT F MAEDA Y CHUNG K | | 0，，11： | 1 |
| 14 | Trankforming growth factor - beta enhances connective tissue growth factor expression in L6 rat skeletal myotubes 显示文摘 | Maeda N Kanda F Oknda S | 2005 | Neuromuscular Disorders2005，15，11： | 1 |
| 15 | Yielding description of solution strengthened aluminium alloys显示文摘 | BARLAT F BECKER R C HAYASHIDA Y MAEDA Y YANAGAWA M CHUNG K BREM J C LEGE D J MATSUI K MURTHA S J HATTORI S | 1997 | Int J Plasticity1997，13，： | 1 |
| 16 | Yield function development for aluminium alloy sheets显示文摘 | BARLAT F MAEDA Y CHUNG K YANAGAWA M BREM J C HAYASHIDA Y LEGE D J MATDUI K MURTHA S J HATTORI S BECKER R C MAKOSEY S | 1997 | J Mech Phys Solids1997，45，1112： | 1 |
| 17 | Dermatomyositis associated with rapidly progressive fatal interstitial pneumonitis and pneumomediastinum 显示文摘 | Yamanishi Y Maeda H Konishi F | 1999 | Scand J Rheumatol1999，28，： | 1 |
| 18 | Aggravation of brain injury after transient focal ischemia in p53-deficient mice显示文摘 | Maeda K Hata R Gillardon F | 2001 | Mol Brain Res2001，88，： | 1 |
| 19 | Development of an equine her-pesvirus type 4- specific enzyme-linked immunosorbent assay using a B-cell epitope as an antigen 显示文摘 | Maeda K Mizukoshi F Hamano M | 2004 | J Clin Microbiol2004，42，3： | 1 |
| 20 | Expression and localization of Fas ligand and Fas during atresia in porcine ovarian follicles显示文摘 | Inoue N Maeda A Matsuda-Minehata F | 2006 | J Reprod Dev2006，52，6： | 1 |
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