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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | 1989-1994年中国脊髓灰质炎病毒的分子流行病学显示文摘1989~1994年中国发生的脊髓灰质炎流行,疫情开始集中于华东、中南地区,后期趋于南部沿海一带。对近百份来自18个省、市、自治区脊灰病毒流行期间标本的分子生物学特征分析,发现流行主要由脊灰病毒Ⅰ型野毒株引起,未发现Ⅱ型野毒株,但1993年在新疆分离到1株Ⅲ型野毒株。Ⅰ型野毒株中共存在4个基因型病毒,其中CHNP1-R91型病毒为这几年流行中新产生的重组病毒,在VP1/2A区含有一段疫苗株序列,另一段野毒株序列很可能来自CHNP1-JX89型病毒。这两个基因型病毒分布在全国大部份地区。病毒核酸的亲缘关系研究还证明,92~94年流行在南方沿海一带的脊髓灰质炎,主要由91年产生的重组病毒引起。此研究揭示了各地区、各基因型病毒与疫情之间的流行病学关系及传播模式。 | 郑渡平 张礼璧 侯晓辉 朱宏 Mac Otten David R Kilpatnck Mark Pallansch Olen M Kew | 1995 | 病毒学报1995，11，4： | 4 |
| 3 | Nutritional therapy for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most frequent primary liver cancer and presents together with cirrhosis in most cases.In addition to commonly recognized risk factors for HCC development,such as hepatitis B virus/hepatitis C virus infection,age and alcohol/tobacco consumption,there are nutritional risk factors also related to HCC development including high intake of saturated fats derived from red meat,type of cooking(generation of heterocyclic amines)and contamination of foods with aflatoxins.On the contrary,protective nutritional factors include diets rich in fiber,fruits and vegetables,n-3 polyunsaturated fatty acids and coffee.While the patient is being evaluated for staging and treatment of HCC,special attention should be paid to nutritional support,including proper nutritional assessment and therapy by a multidisciplinary team.It must be considered that these patients usually develop HCC on top of long-lasting cirrhosis,and therefore they could present with severe malnutrition.Cirrhosisrelated complications should be properly addressed and considered for nutritional care.In addition to traditional methods,functional testing,phase angle and computed tomography scan derived skeletal muscle index-L3 are among the most useful tools for nutritional assessment.Nutritional therapy should be centered on providing enough energy and protein to manage the increased requirements of both cirrhosis and cancer.Supplementation with branched-chain amino acids is also recommended as it improves response to treatment,nutritional status and survival,and finally physical exercise must be encouraged and adapted to individual needs. | Astrid Ruiz-Margáin Berenice M Román-Calleja Paulina Moreno-Guillén JoséA González-Regueiro DeyaniraKúsulas-Delint Alejandro Campos-Murguía Nayelli C Flores-García Ricardo Ulises Macías-Rodríguez | 2021 | World Journal of Gastrointestinal Oncology2021，13，10： | 4 |
| 4 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 5 | A systems biology perspective on sVEGFR1 : itsbiological function, function, pathogenic role and therapeutic use 显示文摘 | Wu F T Stefanini M O Mac Gabhann F | 2010 | J Cell Mol2010，14，3： | 1 |
| 6 | Course of illness,hippocampal function and hippocampal volume in major depression显示文摘 | Mac Queen G M Campbell S McEwen B S | 2003 | PNAS2003，100，3： | 1 |
| 7 | Preparation and characterization of (3-aminopropyl)triethoxysilane-coated magnetite nanoparticles显示文摘 | M Yamaura R.L Camilo L.C Sampaio M.A Macêdo M Nakamura H.E Toma | 2004 | Journal of Magnetism and Magnetic Materials2004，，2： | 1 |
| 8 | Anaerobic digestion of organicsolid wastes:Anoverview of research achievements and perspectives显示文摘 | Alvarez J M Macés L P | | 0，，74： | 1 |
| 9 | On the diffusion of biological population显示文摘 | Gurtin M E Mac Cammy R C | | 0，，： | 1 |
| 10 | Preparation,electrical,mechanical and thermal properties of composite bipolar plate for a fuel cell显示文摘 | KUAN H C MAC C M CHEN K H | 2004 | Journal of Power Sources2004，134，： | 1 |
| 11 | Image texture analysis:methods and comparisons显示文摘 | Bharati M H Liu J J Mac Gregor J F | 2004 | Chemometrics and Intelligent Laboratory Systems2004，72，1： | 1 |
| 12 | A prospective,longitudinal study of percentage of time spent ill in patients with bipolar I or bipolar II disorders显示文摘 | Joffe RT Mac Queen GM Marriott M | 2004 | Bipolar Disorders2004，6，1： | 1 |
| 13 | Performance test and flow visualization of ball valve 显示文摘 | CHERN M J WANG C C MAC H | 2007 | Experimental Thermal and Fluid Science2007，，31： | 1 |
| 14 | Clinical efficacy of moxifloxacin in the treatment of exacerbations of chromic bronchitis:a systematic review and Meta-analysis 显示文摘 | Marc M Jesus M Mac B | 2007 | Archivos de Bronconeumologia2007，43，1： | 1 |
| 15 | A protocol显示文摘 | Khosrowshahi A C Dehghan M Pedrarn novel multi channel sensor network MAC H | 2009 | Systems and Networks Communications2009，，9： | 1 |
| 16 | Wildfire-produced charcoal directly influences nitrogen cycling in ponderosa pine forests 显示文摘 | Deluca T H Mac Kenzie M D Gundale M J | 2006 | Soil Science Society of America Journal2006，70，： | 1 |
| 17 | Image texture analysis:methods and comparisons显示文摘 | Bharati M H Liu J J Mac G | | 0，，01： | 1 |
| 18 | Sagittal spino - pelvic alignment in chronic low back pain 显示文摘 | Chaleat - Vlayer E Mac - Thiong J M Paquet J | 2011 | Eur Spine J2011，20，5： | 1 |
| 19 | The inhibitor of apoptosis protein-binding domain of Smac is not essential for its proapoptotic activity显示文摘 | Roberts DL Merrison W Mac Farlane M | 2001 | J Cell Biol2001，153，1： | 1 |
| 20 | Positron emission tomography is superior to computed tomography scanning for response-assessment after radical radiotherapy or chemoradiotherapy in patients with non-small-cell lung cancer显示文摘 | Mac M Hicks RJ Matthews JP | 2003 | J Clin Oncol2003，21，7： | 1 |
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