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265篇 您的检索式:作者名="Macleod R"
    题名 作者 年代 出处 被引量
1FK506对实验性卒中疗效的系统评价和Meta分析显示文摘FK506是治疗急性卒中的一种候选用药。决定一种药物是否可以用于临床试验,应当以全面的、无偏倚的动物实验数据的评估为依据,同时还应考虑到这些数据的局限性。这种评估不但应包括药物疗效,而且也应包括药效在体内的特征和局限性。本研究应用系统评价和Meta分析的方法对FK506在卒中动物模型中保护作用的证据进行评价。总共纳入了29个描述了实验步骤的研究,包括1759只动物。结果显示,FK506疗效的点估计值(结局指标的改善)是31.3%[95%CI(0.272-0.354)]。在采用氯胺酮麻醉和短暂性脑缺血的动物实验中,FK506的疗效更高,在使用大鼠,合并其他疾病的动物及仅以梗死面积为疗效指标的实验中,FK506疗效较低。已发表的实验研究质量均接近临床试验标准,但在高质量的研究中,FK506的疗效较低。FK506在实验性脑卒中的研究中,虽然显示出有明显的疗效,但是应注意由于研究质量和可能的发表偏倚等冈素的影响,FK506的疗效可能被过高估计。Malcolm R Macleod Tori O’Collins Laura L Horky David W Howells Geoffrey A Donnan 段建钢 2006中国循证医学杂志2006,6,6:3
2Prediction of in-hospital mortalityand length of stay using an early warning scoeing system:clinical audit显示文摘Paterson R Macleod DC Thetford D 2006Clin Med2006,6,3:1
3A prospective cohort study of maternal and neonatal morbidity in relation to use of episiotomy at op- erative vaginal delivery 显示文摘Macleod M Strachan B Bahl R 2008B JOG2008,115,13:1
4Combined use of con- focal laser scanning microscopy and DVT simulation for estima- ting the composition and physical properties of petroleum in fluid inclusions显示文摘Aplin A C Macleod G Larter S R 1999Marine and Petroleum Geology1999,16,2:1
5Hydrogenation of low molecular weight polymers in ionic liquids and the effects of added salt 显示文摘MacLeod S Rosso R 2003Advanced Synthesis and Catalysis2003,345,5:1
6Treatment of severe steroid- dependent nephrotic syndrome (SDNS) in children with tacrolimus 显示文摘Sinha MD MacLeod R Rigby E 2006Nephrol Dial Transplant2006,21,7:1
7A randomised controlled tri- al of routine versus restrictive use of episiotomy at operative vaginal delivery:a muhicentre pilot study 显示文摘Murphy D J Macleod M Bahl R 2008B JOG2008,115,13:1
8The familial Parkinsonism gene LRRK2 regulates neurite process morphology 显示文摘MacLeod D Dowman J Hammond R 2006Neuron2006,52,4:1
9An improved perfusion apparatus for small animal hearts显示文摘Curtis MJ Macleod BA Tabrizchi R 1986J Pharmacol Methods1986,15,:1
10Angiotensinconverting enzyme genotype and the ventilatory response to exertional hypoxia显示文摘S Patel D R Woods N J Macleod 2003Eur Respir J2003,22,5:1
11Combined use of confocal laser scanning microscopy and PVT simulation for estimating the composition and physical properties of petroleum in fluid inclusions显示文摘Aplin A C Macleod G Larter S R Pedersen K S Sorensen H Booth T 1999Mar Pet Geol1999,16,2:1
12Anncxin A2 is a novel RNA-binding protein显示文摘FILIPENKO N R MACLEOD T J YOON C S 2004J Biol Chem2004,279,10:1
13Polypeptide compontents of Wound tumor virus and reovirus 显示文摘Reddy D Macleod R 1976Virology1976,70,:1
14Patterns of alcohol use in early adolescence predict problem use at age 16显示文摘Heron J Macleod J Munaf6 M R 2012Alcohol and Al- coholism2012,47,2:1
15Combined use of con-focal laser scanning microscopy and pVT simulation for estima- ting the composition and physical properties of petroleum in fluid inclusions显示文摘Aplin A C Macleod G Larter S R 1999Marine and Petroleum Geology1999,16,2:1
16Ion-beam-assisted deposition of thin films显示文摘MARTIN P J MACLEOD H A NETTERFIELD R P 1983Appl Opt1983,22,1:1
17Integrated study of the Judy Field (Block 30/7a): An overpressured central North Sea oil/gas field显示文摘Swarbrick R E Osborne M J Grunberger D Yardley G S Macleod G Aplin A C Larter S R Knight I Auld H A 2000Mar Pet Geol2000,17,9:1
18Prediction of in -hospital mortality and length of stay using an early warning scoringsystem: clinical audit显示文摘Paterson R MacLeod DC Thetford D 2006Clin Med2006,6,3:1
19A quantitative comparison of change-detection algorithms for monitoring eelgrass from Remotely sense data 显示文摘 Congalton R G 1998Photogrammetric of engineering and Remote sensing1998,64,3:1
20Treatment of severe steroid-dependent nephrotic syndrome (SDNS) in children with tacrolimus显示文摘Sinha M D Macleod R Rigby E 0,,07:1
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