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| 1 | Does combined therapy of curcumin and epigallocatechin gallate have a synergistic neuroprotective effect against spinal cord injury?显示文摘Systematic inflammatory response after spinal cord injury(SCI) is one of the factors leading to lesion development and a profound degree of functional loss. Anti-inflammatory compounds, such as curcumin and epigallocatechin gallate(EGCG) are known for their neuroprotective effects. In this study, we investigated the effect of combined therapy of curcumin and EGCG in a rat model of acute SCI induced by balloon compression. Immediately after SCI, rats received curcumin, EGCG, curcumin + EGCG or saline [daily intraperitoneal doses(curcumin, 6 mg/kg; EGCG 17 mg/kg)] and weekly intramuscular doses(curcumin, 60 mg/kg; EGCG 17 mg/kg)] for 28 days. Rats were evaluated using behavioral tests(the Basso, Beattie, and Bresnahan(BBB) open-field locomotor test, flat beam test). Spinal cord tissue was analyzed using histological methods(Luxol Blue-cresyl violet staining) and immunohistochemistry(anti-glial fibrillary acidic protein, anti-growth associated protein 43). Cytokine levels(interleukin-1β, interleukin-4, interleukin-2, interleukin-6, macrophage inflammatory protein 1-alpha, and RANTES) were measured using Luminex assay. Quantitative polymerase chain reaction was performed to determine the relative expression of genes(Sort1, Fgf2, Irf5, Mrc1, Olig2, Casp3, Gap43, Gfap, Vegf, NfκB, Cntf) related to regenerative processes in injured spinal cord. We found that all treatments displayed significant behavioral recovery, with no obvious synergistic effect after combined therapy of curcumin and ECGC. Curcumin and EGCG alone or in combination increased axonal sprouting, decreased glial scar formation, and altered the levels of macrophage inflammatory protein 1-alpha, interleukin-1β, interleukin-4 and interleukin-6 cytokines. These results imply that although the expected synergistic response of this combined therapy was less obvious, aspects of tissue regeneration and immune responses in severe SCI were evident. | Jiri Ruzicka Lucia Machova Urdzikova Barbora Svobodova Anubhav G. Amin Kristyna Karova Jana Dubisova Kristyna Zaviskova Sarka Kubinova Meic Schmidt Meena Jhanwar-Uniyal Pavla Jendelova | 2018 | Neural Regeneration Research2018，13，1： | 4 |
| 2 | 调节服装微循环气候的经编间隔织物显示文摘德国德累斯顿工业大学纺织服装学院对经编间隔织物的舒适性能进行了研究,该项计划编号为ALF13086,主要针对于经编间隔织物的产品开发及其性能研究,目的是探讨经编间隔织物选用纤维材料以及纤维的数量对织物热湿传递性能的影响。 | K. Machova G. Hoffmann C. Cherif 钱程(译) 申熠(校) | 2007 | 国际纺织导报2007，35，3： | 1 |
| 3 | Antioxidant activity of me- dicinal plant polysaccharides显示文摘 | Kardosova A Machova E | 2006 | Fitoterapia2006，77，： | 1 |
| 4 | Atomistic simulation of stacking fault formation in bee iron 显示文摘 | Machova A Beltz G E Chang M | 1999 | Modelling Simul Mater Sci Eng1999，7，： | 1 |
| 5 | Epidemi- ology of esophageal cancer-an overview article显示文摘 | Kollarova H Machova L Horakova D | 2007 | Bi- omed Pap Med Fac Univ Palacky Olomouc Czech Repub2007，151，1： | 1 |
| 6 | Listeria monoeytogenes infection in macrophages induces vacuolar-dependent host miRNA response显示文摘 | Sehnitger AK Machova A Mueller RU | 2011 | PLoS One2011，6，27： | 1 |
| 7 | Effects of subchronic nitrite exposure on rainbow trout ( Oncorhynchus mykiss ) 显示文摘 | KROUPOVA H MACHOVA J PIACKOVA V | 2008 | Ecotoxicol and Environ Saf2008，71，3： | 1 |
| 8 | Mitogenic activity of particulate yeast β-( 1-3)-D-glucan and its water-soluble derivatives显示文摘 | sandula J Machova E Hlibalova V | 1995 | Bio Macromol1995，17，6： | 1 |
| 9 | Mitogenic activity of particulate yeast β-(1,3) D-glucan and its water-soluble derivatives显示文摘 | Sandula J Machova E Hfibalova V | 1995 | Int J Biol Macromol1995，17，6： | 1 |
| 10 | Nitrite influence on fish:a review显示文摘 | Kroupova H Machova J Svobodova Z | 2005 | Vet Med Czech2005，50，11： | 1 |
| 11 | Epidemiology of esophageal cancer-an overview article显示文摘 | Kollarova H Machova L Horakova D ct al | 2007 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub2007，151，： | 1 |
| 12 | Nitrite influence on fish:a review显示文摘 | Kroupova H Machova J Svobodova Z | 2005 | Vet Med-Czech2005，50，11： | 1 |
| 13 | Effect of a synthetic analogue of vasopressin in animals and in patients with diabetes insipidus 显示文摘 | VAVRA I MACHOVA A HOLECEK V | 1968 | Lancet1968，1，7549： | 1 |
| 14 | Antioxidant capacities of mannansand glucans are related to their susceptibility of free radicaldegradation显示文摘 | MACHOVA E BYSTRICKY S | 2013 | International Journal of Biological Macromolecules2013，61，10： | 1 |
| 15 | Expression patterns of microRNAs associated with CML phases and their disease related targets显示文摘 | Machova Polakova K Lopotova T Klamova H | 2011 | Mol Cancer2011，10，： | 1 |
| 16 | Candida albicans mannan-protein conjugate as vaccine candidate显示文摘 | Bystricky S Paulovicova E Machova E | 2003 | Immunol Lett2003，85，3： | 1 |
| 17 | Nitrite influence on fish:A review显示文摘 | KROUPOVA H MACHOVA J SVOBODOVA Z | 2005 | Ver Med Czech2005，50，11： | 1 |
| 18 | Epidemiology of esophageal cancer-an overview article显示文摘 | Kollarova H Machova L Horakova D | 2007 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub2007，151，1： | 1 |
| 19 | Immunomodulatory activity of particulate yeast β-1,3-D-glucan and its water-soluble derivatives显示文摘 | Si I andula J Machova'E H11 ly'balova' V | 1995 | International Journal of Biological Macromolecules1995，17，： | 1 |
| 20 | Enzymatic alterations and RNA/DNA ratio in intestine of rainbow trout, Oncorhynchus mykiss, induced by chronic exposure to carbamazepine显示文摘 | Zhi-Hua Li Vladimir Zlabek Roman Grabic Josef Velisek Jana Machova Tomas Randak | 2010 | Ecotoxicology2010，，5： | 1 |
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