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| 1 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 3 | Immunotherapy for de novo renal transplantation :what's in the pipeline? 显示文摘 | TEDESCO SILVA H JR PINHEIRO MACHADO P ROSSO FELIPE C | 2006 | Drugs2006，66，13： | 1 |
| 4 | Sporadic primary pulmonary hypertension is associated with germline mutations of the geneneodlng BMPR - Ⅱ , a receptor member of the TGF-β family显示文摘 | Thompson JR Machado RD Pauciulo MW | 2000 | J Med Genet2000，37，： | 1 |
| 5 | Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-Ⅱ, a receptor memberof the TGF-beta family显示文摘 | Thomson JR Machado RD Paueiulo MW | 2000 | J Med Genet2000，37，10： | 1 |
| 6 | Microcalcifications versus artifacts:initial evaluation of a new ultrasound image processing technique to identify breast microcalcifications in a screening population显示文摘 | Machado P Eisenbrey JR Cavanaugh B | 2014 | Ultrasound Med Biol2014，40，9： | 1 |
| 7 | Glutamatergic modulators:the future of treating mood disorders?显示文摘 | Zarate C Jr Machado Vieira R Henter I | 2010 | Harv Rev Psychiatry2010，18，5： | 1 |
| 8 | Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-Ⅱ , a receptor memberof the TGF-beta family显示文摘 | Thomson JR Machado RD Pauciulo MW | 2000 | J Med Genet2000，37，10： | 1 |
| 9 | Comparative study between video endoscopic inguinal lymphadenectomy (VEIL) and standard open procedure for penile cancer:preliminary surgical and oncological results显示文摘 | Machado MT Tavares A Molina Jr WR | 2005 | J Urol2005，173，： | 1 |
| 10 | IgA nephropathy: histological analysis and clinicomorfological correlation in patients from Minas Gerais State显示文摘 | Neves PD Machado JR Silva MV | 2012 | J Bras Nefrol2012，34，2： | 1 |
| 11 | Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia显示文摘 | Trembath RC Thomson JR Machado RD | 2001 | N Engl J Med2001，345，5： | 1 |
| 12 | New image processing technique for evaluating breast microcalcifications: A comparative study显示文摘 | MacHado P Eisenbrey JR Cavanaugh B | 2012 | Ultrasound Med2012，31，6： | 1 |
| 13 | Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-β family 显示文摘 | Thomson JR Machado RD Pauciulo MW | 2000 | J Med Genet2000，37，10： | 1 |
| 14 | Comparative study between videendoscope in guihal lymphadenectomy (VEIL) and Standard open procedure for penile cancer:preliminary surgical and ontological results显示文摘 | Machado MT Molina WR Jr Tavares A | 2005 | Jurlo2005，173，： | 1 |
| 15 | New image processing technique for evaluating breast microcalcifica- tions : a comparative study 显示文摘 | Machado P Eisenbrey JR Cavanaugh B | 2012 | J Ultrasound Med2012，31，6： | 1 |
| 16 | Effect of indo- methacin on surface treatment and intracanal dressing of replanted teeth in dogs 显示文摘 | Zanetta-Barbosa D Moura CC Machado JR | 2014 | J Oral Maxillofac Surg2014，72，1： | 1 |
| 17 | BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension显示文摘 | Machado RD Pauciulo MW Thomson JR | 2001 | Am J Hum Genet2001，68，： | 1 |
| 18 | Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-IIBMPR2, a receptor member of the TGF-family显示文摘 | Thomson JR Machado RD Pauciulo MW | 2000 | J Med Genet2000，37，： | 1 |
| 19 | BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension显示文摘 | Machado RD Pauciulo MW Thomson JR | 2001 | Am J Hum Genet2001，68，1： | 1 |
| 20 | BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension 显示文摘 | Machado RD Pauciulo MW Thomson JR | 2001 | Am J Hum Genet2001，68，1： | 1 |
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