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| 1 | Inflammatory bowel disease:Epidemiology,pathology and risk factors for hypercoagulability显示文摘Hypercoagulability observed in patients with inflammatory bowel diseases(IBD)may lead to thromboembolic events(TE),which affect the venous and arterial systems alike and are an important factor in patients’morbidity and mortality.The risk of TE in IBD patients has been demonstrated to be approximately threefold higher as compared to the general population.The pathogenesis of thrombosis in IBD patients is multifactorial and not fully explained.The most commonly listed factors include genetic and immune abnormalities,disequilibrium between procoagulant and anticoagulant factors,although recently,the role of endothelial damage as an IBD-triggering factor is underlined.Several studies report that the levels of some coagulation enzymes,including fibrinogen,factorsⅤ,Ⅶ,Ⅷ,active factorⅪ,tissue factor,prothrombin fragment 1+2and the thrombin-antithrombin complex,are altered in IBD patients.It has been demonstrated that there is a significant decrease of tissue plasminogen activator level,a marked increase of plasminogen activator inhibitor type 1 and thrombin-activable fibrinolysis inhibitor,a significantly lower level of antithrombinⅢand tissue factor pathway inhibitor.IBD patients have been also observed to produce an increased amount of various anticoagulant antibodies.Hyperhomocysteinemia,which is a potential risk factor for TE was also observed in some IBD patients.Further studies are necessary to assess the role of coagulation abnormalities in IBD etiology and to determine indications for thromboprophylactic treatment in patients at high risk of developing TE. | Danuta Owczarek Dorota Cibor Mikolaj K Glowacki Tomasz Rodacki Tomasz Mach | 2014 | World Journal of Gastroenterology2014，20，1： | 16 |
| 2 | IL28B polymorphism as a predictor of antiviral response in chronic hepatitis C显示文摘AIM:To evaluate the effect of single nucleotide polymorphisms of interleukin(IL)-28B,rs12979860 on progression and treatment response in chronic hepatitis C.METHODS:Patients(n = 64;37 men,27 women;mean age,44 ± 12 years) with chronic hepatitis C,genotype 1,received treatment with peg-interferon plus ribavirin.Genotyping of rs12979860 was performed on peripheral blood DNA.Histopathological assessment of necroinflammatory grade and fibrosis stage were scored using the METAVIR system on a liver biopsy sample before treatment.Serum viral load,aminotransferase activity,and insulin level were measured.Insulin resistance index,body mass index,waist/hip ratio,percentage of body fat and fibrosis progression rate were calculated.Applied dose of interferon and ribavirin,platelet and neutrophil count and hemoglobin level were measured.RESULTS:A sustained virological response(SVR) was significantly associated with IL28B polymorphism(CC vs TT allele:odds ratio(OR),25;CC vs CT allele:OR,5.4),inflammation activity(G < 1 vs G > 1:OR,3.9),fibrosis(F < 1 vs F > 1:OR,5.9),platelet count(> 200 × 10 9 /L vs < 200 × 10 9 /L:OR,4.7;OR in patients with genotype CT:12.8),fatty liver(absence vs presence of steatosis:OR,4.8),insulin resistance index(< 2.5 vs > 2.5:OR,3.9),and baseline HCV viral load(< 10 6 IU/mL vs > 10 6 IU/mL:OR,3.0).There was no association with age,sex,aminotransferases activity,body mass index,waist/hip ratio,or percentage body fat.There was borderline significance(P = 0.064) of increased fibrosis in patients with the TT allele,and no differences in the insulin resistance index between groups of patients with CC,CT and TT alleles(P = 0.12).Spearman's rank correlation coefficient between insulin resistance and stage of fibrosis and body mass index was r = 0.618 and r = 0.605,respectively(P < 0.001).Significant differences were found in the insulin resistance index(P = 0.01) between patients with and without steatosis.Patients with the CT allele and absence of a SVR had a higher incidence of requiring threshold dose reduction of interferon(P = 0.07).CONCLUSION:IL28B variation is the strongest host factor not related to insulin resistance that determines outcome of antiviral therapy.Baseline platelet count predicts the outcome of antiviral therapy in CT allele patients. | Andrzej Ciela Monika Bociaga-Jasik Iwona Sobczyk-Krupiarz Mikolaj K Glowacki Danuta Owczarek Dorota Cibor Marek Sanak Tomasz Mach | 2012 | World Journal of Gastroenterology2012，18，35： | 4 |
| 3 | Genetic improvement of Trichoderma ability to induce systemic resistance显示文摘The beneficial applications of Trichoderma spp. in agriculture include not only the control of plant pathogens, but also the improvement of plant growth, micronutrient availability, and plant tolerance to abiotic stress. In addition, it has been suggested that these fungi are able to increase plant disease resistance by activating induced systemic resistance (ISR) . The mode of action of these beneficial fungi in the Trichoderma -plant-pathogen interaction are many, complex and not completely understood. Numerous lytic enzymes have been characterized, the encoding genes (ech42 gluc78, nag1 from T. atroviride strain P1) cloned, and their role in biocontrol demonstrated. The corresponding biocontrol-related inducible promoters have been used in a reporter system based on the Aspergillus niger glucose oxidase gene (goxA) to monitor biocontrol activity. Glucose oxidase catalyzes the oxygen-dependent oxidation of D-glucose to D-glucono-1,5-lactone and hydrogen peroxide; this latter compound is known to have an antifungal effect and activate the plant defence cascade, thus increasing resistance to pathogen attack. T. atroviride P1 transformants with various promoters gox were tested as seed coating treatments on bean seeds planted in soil infested with a soilborne fungal pathogen. Successively, the emergent leaves were inoculated with a foliar pathogen to determine the effect of the GOX transformants on biocontrol and resistance to pathogen attack. Inoculations with the P1-GOX transformants not only reduced disease symptoms caused by a soil pathogen, but also the lesions of various foliar pathogens applied far from the Trichoderma colonization, thus activating ISR. A similar approach is being use to genetically improve T. harzianum T22, a rhizosphere competent and commercially marketed strain not transformed yet, by using four different gox gene constructs under the control of constitutive and inducible promoters. Plasmids have been introduced in Trichoderma by protoplasts co-transformation. hygromicin resistant progeny selected, and mitotically stable transformants analysed to confirm the presence of the novel enzyme activity. Progenies are being tested for biocontrol ISR inducing activity. | Ciliento R Woo S L Di Benedetto P Ruocco M Scala F Soriente I Ferraioli S Brunner K Zeilinger S Mach R L Lorito M | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 2 |
| 4 | Regulation of matrix metalloproteinase expression in human vascular smooth muscle cells by T lymphocytes:a role for CD40 signaling in plaque rupture显示文摘 | Schonbeck U Mach F Sukhova G K | 1997 | Circ Res1997，81，3： | 1 |
| 5 | Functional CD40 ligand is expressed on human vascular endothelial cells,smooth muscle cells and macrophages: implication for CD40-CD40L (ligand signaling in atherosclerosis) 显示文摘 | Francols Mach Uwe schonbeck Galina K | 1997 | Proc Natl Acad Sci USA1997，96，5： | 1 |
| 6 | Functional ligand is expressed on human vascular endothelial cells,and macrophages:implications for CD40-CD40 ligand signaling in atherosclerosis显示文摘 | Mach F Schonbeck U Sukhova G K | 1997 | Proc Natl Acad Sci USA1997，94，3： | 1 |
| 7 | CD40 ligation induces tissue factor expression in human vascular smooth muscle cells显示文摘 | FRANCOIS MACH GALINA K | 2000 | American Journal of Pathology2000，156，： | 1 |
| 8 | Inhibition of CD40 signaling limits evolution established atherosclerosis in mice显示文摘 | Schonbeck U Sukhova GK Shimizu K Mach F Libby P | 2000 | Proc Natl Acad Sci USA2000，97，： | 1 |
| 9 | Trichoderma:from genes to biocontrol显示文摘 | KUBICEK C P MACH R L PETERBAUER C K | 2001 | Journal of plant pathology2001，83，2： | 1 |
| 10 | Wire bonding at higher ultrasonic fiequencies: reliability and process implications 显示文摘 | H K Charles Jr K J Mach S J Lehtonen | 2003 | Microelectronics Reliability2003，43，2003： | 1 |
| 11 | The analysis of RCAS1, HLA-G, and B7H4-positive macrophages in partial and complete hydatidiform mole in both applied therapeutic surgery and surgery followed by chemotherapy 显示文摘 | Basta P Galazka K Mach P | 2011 | Am J Reprod Immunol2011，65，2： | 1 |
| 12 | Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplantation but does not prevent graft arteriosclerosis显示文摘 | Shimizu K Sch(o)nbeck U Mach F | 2000 | J Immunol2000，165，6： | 1 |
| 13 | Functional CD40 ligand is expressed on human vascular endothelial cells,smooth muscle ceHs,and macrophages:implication for CD40-CD40 ligand in atherosclerosis显示文摘 | Mach F Schonbeck U Sukhova G K | | 0，，： | 1 |
| 14 | The immunohistochemical a-nalysis of RCAS1, HLA-G, and B7H4-positive macrophages in partial and complete hydatidiform mole in both applied thera peutic surgery and surgery followed by chemotherapy 显示文摘 | Basta P Galazka K Mach P | 2011 | Am J Reprod Immunol2011，65，2： | 1 |
| 15 | Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells and macrophages:Implication for CD40-CD40 ligand signaling in atherosclerosis 显示文摘 | MACH F SCHONBECK U SUKHOVA G K | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 16 | Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells and macrophages: implication for CD40-CD40 ligand signaling in atherosclerosis 显示文摘 | MACH F SCHONBECK U SUKHOVA G K | 1997 | Proc Natl Acad Sci USA1997，94，15： | 1 |
| 17 | ,Reduction of atherosclerosis in mice by inhibition of CD40 signalling显示文摘 | MACH F SCHONBECK U SUKHOVA G K | 1998 | Nature1998，394，： | 1 |
| 18 | Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplantation but does not prevent graft arteriosclerosis显示文摘 | Schonbeck U Mach F | 2000 | J Immunol2000，165，6： | 1 |
| 19 | Psychotramna anti effective treatment of post-traumatic stress disorder in soldiers and peacekeepers显示文摘 | Vitzthum K Mache S Joachin R | 2009 | J Occup Med Toxicol2009，4，2： | 1 |
| 20 | Cognitive-en-hancing Substance Use at German Universities:Frequency,Reasons and Gender Differences 显示文摘 | Mache S Eickenhorst P Vitzthum K | 2012 | Wien Med Wochens-chr2012，162，： | 1 |
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