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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | New advances on glial activation in health and disease显示文摘In addition to being the support cells of the central nervous system(CNS), astrocytes are now recognized as active players in the regulation of synaptic function, neural repair, and CNS immunity. Astrocytes are among the most structurally complex cells in the brain, and activation of these cells has been shown in a wide spectrum of CNS injuries and diseases. Over the past decade, research has begun to elucidate the role of astrocyte activation and changes in astrocyte morphology in the progression of neural pathologies, which has led to glial-specific interventions for drug development. Future therapies for CNS infection, injury,and neurodegenerative disease are now aimed at targeting astrocyte responses to such insults including astrocyte activation, astrogliosis and other morphological changes, and innate and adaptive immune responses. | Kim Mai Lee Andrew G Mac Lean | 2015 | World Journal of Virology2015，4，2： | 13 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | The effect of wind gusts, moisture content and fetch length on sand transport on a beach显示文摘 | Davidson-Arnotta R G D Mac Quarriea K Aagaardb T | 2005 | Geomorphology2005，68，： | 1 |
| 5 | Course of illness,hippocampal function and hippocampal volume in major depression显示文摘 | Mac Queen G M Campbell S McEwen B S | 2003 | PNAS2003，100，3： | 1 |
| 6 | Spontaneous tumors in dogs and cats: models for the study of cancer biology and treatment显示文摘 | Mac Ewen E G | 1990 | Cancer Metastasis Rev1990，，9： | 1 |
| 7 | Elimination of false positives gene rated through PCR Re-amplification of differential display cDNA显示文摘 | Miele G Mac ReaL Mc Bride D | 1998 | Biol Techniques1998，25，： | 1 |
| 8 | Molecular analysis of 30 Niemann-Pick type C patients from Spain显示文摘 | Macías-Vidal J Rodríguez-Pascau L Sánchez-Ollé G | 2011 | Clin Genet2011，80，1： | 1 |
| 9 | Matemalhaemodynamics at elective caesarean section: a randomized comparison of of oxytocin 5-unit bolus and placeboinfusion with oxytocin 5-unit bolus and 30-unit infusin显示文摘 | McLeod G Munishankar B Mac Gregor H | 2010 | Int J Obstet Anesth2010，19，2： | 1 |
| 10 | Planar antennas in LTCC technology with transceiver integration capability for ultra-wideband applications 显示文摘 | Brzezina G Roy L Mac Eachern L | 2006 | IEEE Transaction on microwave theory and techniques2006，54，6： | 1 |
| 11 | Image texture analysis:methods and comparisons显示文摘 | Bharati M H Liu J J Mac G | | 0，，01： | 1 |
| 12 | Renal epithelioid angiomyolipoma显示文摘 | Bing Z Mac Lennan G T | 2009 | J Urol2009，182，5： | 1 |
| 13 | Preparative separation and purifica- tion of rosavin in Rhodiola rosea by macroporous adsorption resins 显示文摘 | MAC Y TAO G J TANG J | 2009 | Sep Purif Technol2009，69，1： | 1 |
| 14 | The influence of magnesium on carbide characteristics and creep behavior of the MAR-M247 superalloy显示文摘 | BOR H Y CHAO C G MAC Y | 1998 | Scripta Materialia1998，38，2： | 1 |
| 15 | Glucose determination by a pulsed photoacoustic technique:an experimental study using a gelatin-based tissue phantom显示文摘 | K M Quan G B Christison H A Mac Kenzie P Hodgson | 1993 | Physics in medicine and biology1993，38，12： | 1 |
| 16 | Special issues in the management of depression in women 显示文摘 | Mac Queen G Chokka P | 2004 | Can J Psychiatry2004，97，49： | 1 |
| 17 | Pelvic floor muscle training versus no treatment, or inactive control treatments, for urinary incontinence in women 显示文摘 | Dumoulin C Hay - Smith EJ Mac Hab6e -S6guin G | 2014 | Cochrane Database Syst Rev2014，5，00： | 1 |
| 18 | Creating Evidence-Based Research in Adapted Physical Activity显示文摘 | Reid G Bouffard M Mac Donald C | 2012 | Adapted Physical Activity Quarterly2012，，2： | 1 |
| 19 | Synthesis of electrically conducting organic polymers:halogen derivatives of polyacetylene,(CH)x显示文摘 | Shirakawa H Mac Diarmid A G | 1977 | J Chem Soc1977，16，： | 1 |
| 20 | Studying critical values:adverse event identification following a critical laboratory values study at the Ohio State University Medical Center显示文摘 | Jenkins JJ Mac crawford J Bissell M G | | 0，，： | 1 |
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