|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response显示文摘病毒的 RNA 的识别由 cytosolic 传感器 retinoic 组织酸可诱导的基因 --(RIG-I ) 我导致表明与类型的产生达到顶点的串联的激活我干扰素(IFN ) 抗病毒的反应。对病毒的病原体的抗病毒、煽动性的回答的发作要求表明改编者, kinases 和 transcriptional 蛋白质到 mitochondrial 的调整空间与时间的招募抗病毒的发信号蛋白质(MAVS ) 。我们以前示威了 serine/threonine kinase IKKε被招募到 MAVS 后面的仙台或小囊的口炎病毒(VSV ) 感染的 C 终端区域,在 Lys500 由 MAVS 的连接 Lys63 的 polyubiquitination 调停了,导致下游的 IFN 发信号的抑制(Paz 等,摩尔房间 Biol, 2009 ) 。在这研究,我们证明 MAVS 的 C 终点在 MAVS 的 aa450-468 区域怀有一个新奇 TRAF3 有约束力的地点。一个一致交往 TRAF 主题(提姆) , 455-PEENEY-460,在这以内,地点为 TRAF3 绑定和 IFN 抗病毒的反应基因的激活被要求,而 TIM 的变化消除 TRAF3 绑定和下游的 IFN 反应。有表示 MAVS 的一个变异提姆的版本的构造的 MAVS −/− 老鼠胚胎成纤维细胞的宪法没能恢复抗病毒的反应或块 VSV 复制,而野类型的 MAVS 重新组成 VSV 复制的抗病毒的抑制。而且, IKKε 的招募;到在经由 Lys500 的 MAVS 的一个邻近的 C 终端地点(aa 468-540 ) , ubiquitination 减少了 TRAF3 绑定和蛋白质稳定性,因此贡献 IKKε调停 IFN 反应关机。这研究证明 MAVS 怀有功能的 C 终端参予 IFN 抗病毒的反应的积极、否定的规定的 TRAF3 有约束力的地点。 | Suzanne Paz Myriam Vilasco Steven J Werden Meztli Arguello Deshanthe Joseph-Pillai Tiejun Zhao Thi Lien-Anh Nguyen Qiang Sun Eliane F Meurs Rongtuan Lin John Hiscott | 2011 | Cell Research2011，21，6： | 12 |
| 2 | Family-based association study of matrix metalloproteinase-3 and -9 haplotypes with susceptibility to isehemic white matter injury显示文摘 | Myriam F Mosley TH Jack CR | 2007 | Hum Genet2007，120，5： | 1 |
| 3 | Identification of Monosaccharides by High-performance Liquid Chromatography Using Methanolysis and a Light-scattering Detector显示文摘 | Myriam T Arlette E B Danielle B F | 1990 | J Chromatogr1990，514，1： | 1 |
| 4 | Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury 显示文摘 | PIERRE S MYRIAM T HARAN F | 2006 | Crit Care Med2006，34，4： | 1 |
| 5 | Variation in the region of the angiotensin-converting enzyme gene influences inter individual differences in blood pressure levels in young white males显示文摘 | CHRISTOPHER I AMOS S K | 1998 | Circulation1998，97，： | 1 |
| 6 | Isotopic Analysis of Cd in the Mixing Zone of Siberian Rivers with the Arctic Ocean--New Constraints on Marine Cd Cycling and the Isotope Composition of Riverine Cd 显示文摘 | Myriam L Mark R Tina V F | 2013 | Earth and Planetary Science Letters2013，361，： | 1 |
| 7 | Oral absorption characteristics and pharmacokinetics of coichicine in healthy volunteers after single and multiple doses显示文摘 | Geraldine M F Myriam R william J | 1996 | J Clin Pharmacol1996，36，： | 1 |
| 8 | Endoscopic retrograde chalangiopancreatography in the management of benign biliary strictures显示文摘 | Myriam F Mark ML Michael FB | 2008 | Current Gastroenterology Reports2008，10，： | 1 |
| 9 | Acute pmmyelocytic leukemia: from genetics to treatment 显示文摘 | Francesco G Marta F Myriam A | 1994 | Blood1994，83，： | 1 |
| 10 | AT-CHLORO,A comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins显示文摘 | MYRIAM F SABINE B DANIEL S DAPHNE S B MAGALI C LUCAS M CLAIRE R STEPHANE M MOURAD M SOPHIE L G SYLVIE K J CHRISTOPHE B JEROME G JACQUES J CHRISTOPHE B JEROME G JACQUES J CHRISTOPHE M NORBERT R | 2010 | Molecular and Cellular Proteomics2010，9，： | 1 |
| 11 | Polyanionic dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps in the Virus Replicative Cycle显示文摘 | Valery F Wim P | 2000 | Mol pharmacol2000，，58： | 1 |
| 12 | Adsorption Studies of the Herbicide Simazine in Agricultural Soils of the Aconcagua Valley, Central Chile显示文摘 | CECILIA F VERONICA M MYRIAM G | 2009 | Chemosphere2009，74，11： | 1 |
| 13 | Proteomics of the chloroplast envelope membranes from Arabidopsis thaliana 显示文摘 | MYRIAM F DAN1EL S SABINE B | 2003 | Molecular & Cellular Proteomics2003，，： | 1 |
| 14 | What can we learn from β-cell failure biomarker application in diabetes in childhood?A systematic review显示文摘BACKGROUND The prevalence of diabetes as a catastrophic disease in childhood is growing in the world.The search for novel biomarkers ofβ-cell failure has been an elusive task because it requires several clinical and biochemical measurements in order to integrate the risk of metabolic syndrome.AIM To determine which biomarkers are currently used to identifyβ-cell failure among children and adolescents with high risk factors for diabetes mellitus.METHODS This systematic review was carried out using a modified version of the PICO protocol(Participants/Intervention/Comparison/Outcome).Once our research question was established,terms were individually researched on three different databases(PubMed,BIREME and Web of Science).The total articles obtained underwent a selection process from which the 78 most relevant articles were retrieved to undergo further analysis.They were assessed individually according to quality criteria.RESULTS First,we made the classification of theβ-cell-failure biomarkers by the target tissue and the evolution of the disease,separating the biomarkers in relation to the types of diabetes.Second,we demonstrated that most biomarkers currently used as early signs ofβ-cell failure are those that concern local or systemic inflammation processes and oxidative stress as well as those related to endothelial dysfunction processes.Third,we explored the novelties of diabetes as a protein conformational disease and the novel biomarker called real human islet amyloid polypeptide amyloid oligomers.Finally,we ended with a discussion about the best practice of validation and individual control of using different types of biomarkers in type 1 and type 2 diabetes in order to assess the role they play in the progress of diabetes in childhood.CONCLUSION This review makes widely evident that most biomarkers currently used as early signs ofβ-cell failure are those that concern local or systemic inflammation processes and oxidative stress as well as those related to endothelial dysfunction processes.Landing in the clinical practice we propose that real human islet amyloid polypeptide amyloid oligomers is good for identifying patients withβ-cell damage and potentially could substitute many biomarkers. | María F Calderón-Hernández Nelly F Altamirano-Bustamante Cristina Revilla-Monsalve María Belen Mosquera-Andrade Myriam M Altamirano-Bustamante | 2021 | World Journal of Diabetes2021，12，8： | 0 |
| 15 | GaAs-chip-based mid-infrared supercontinuum generation显示文摘The mid-infrared spectral region opens up new possibilities for applications such as molecular spectroscopy with high spatial and frequency resolution.For example,the mid-infrared light provided by synchrotron sources has helped for early diagnosis of several pathologies.However,alternative light sources at the table-top scale would enable better access to these state-of-the-art characterizations,eventually speeding up research in biology and medicine.Midinfrared supercontinuum generation in highly nonlinear waveguides pumped by compact fiber lasers represents an appealing alternative to synchrotrons.Here,we introduce orientation-patterned gallium arsenide waveguides as a new versatile platform for mid-infrared supercontinuum generation.Waveguides and fiber-based pump lasers are optimized in tandem to allow for the group velocities of the signal and the idler waves to match near the degeneracy point.This configuration exacerbates supercontinuum generation from 4 to 9μm when waveguides are pumped at 2750 nm with few-nanojoule energy pulses.The brightness of the novel mid-infrared source exceeds that of the thirdgeneration synchrotron source by a factor of 20.We also show that the nonlinear dynamics is strongly influenced by the choice of waveguide and laser parameters,thus offering an additional degree of freedom in tailoring the spectral profile of the generated light.Such an approach then opens new paths for high-brightness mid-infrared laser sources development for high-resolution spectroscopy and imaging.Furthermore,thanks to the excellent mechanical and thermal properties of the waveguide material,further power scaling seems feasible,allowing for the generation of watt-level ultra-broad frequency combs in the mid-infrared. | Geoffroy Granger Myriam Bailly Hugo Delahaye Cristian Jimenez Idris Tiliouine Yann Leventoux Jean-Christophe Orlianges Vincent Couderc Bruno Gérard Rezki Becheker Said Idlahcen Thomas Godin Ammar Hideur Arnaud Grisard Eric Lallier Sébastien Février | 2023 | Light(Science & Applications)2023，12，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员