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| 1 | Nonalcoholic fatty liver disease and aging: Epidemiology to management显示文摘Nonalcoholic fatty liver disease(NAFLD) is common in the elderly, in whom it carries a more substantial burden of hepatic(nonalcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma) and extra-hepatic manifestations and complications(cardiovascular disease, extrahepatic neoplasms) than in younger age groups. Therefore, proper identification and management of this condition is a major task for clinical geriatricians and geriatric hepatologists. In this paper, the epidemiology and pathophysiology of this condition are reviewed, and a full discussion of the link between NAFLD and the aspects that are peculiar to elderly individuals is provided; these aspects include frailty, multimorbidity, polypharmacy and dementia. The proper treatment strategy will have to consider the peculiarities of geriatric patients, so a multidisciplinary approach is mandatory. Non-pharmacological treatment(diet and physical exercise) has to be tailored individually considering the physical limitations of most elderly people and the need for an adequate caloric supply. Similarly, the choice of drug treatment must carefully balance the benefits and risks in terms of adverse events and pharmacological interactions in the common context of both multiple health conditions and polypharmacy. In conclusion, further epidemiological and pathophysiological insight is warranted. More accurate understanding of the molecular mechanisms of geriatric NAFLD will help in identifying the most appropriate diagnostic and therapeutic approach for individual elderly patients. | Marco Bertolotti Amedeo Lonardo Chiara Mussi Enrica Baldelli Elisa Pellegrini Stefano Ballestri Dante Romagnoli Paola Loria | 2014 | World Journal of Gastroenterology2014，20，39： | 15 |
| 2 | A secondary bile acid from microbiota metabolism attenuates ileitis and bile acid reduction in subclinical necrotic enteritis in chickens显示文摘Background:Clostridium perfringens-induced chicken necrotic enteritis(NE)is responsible for substantial economic losses worldwide annually.Recently,as a result of antibiotic growth promoter prohibition,the prevalence of NE in chickens has reemerged.This study was aimed to reduce NE through titrating dietary deoxycholic acid(DCA)as an effective antimicrobial alternative.Materials and methods:Day-old broiler chicks were assigned to six groups and fed diets supplemented with 0(basal diet),0.8,1.0 and 1.5 g/kg(on top of basal diet)DCA.The birds were challenged with Eimeria maxima(20,000 oocysts/bird)at d 18 and C.perfringens(109 CFU/bird per day)at d 23,24,and 25 to induce NE.The birds were sacrificed at d 26 when ileal tissue and digesta were collected for analyzing histopathology,mRNA accumulation and C.perfringens colonization by real-time PCR,targeted metabolomics of bile acids,fluorescence in situ hybridization(FISH),or terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)assay.Results:At the cellular level,birds infected with E.maxima and C.perfringens developed subclinical NE and showed shortening villi,crypt hyperplasia and immune cell infiltration in ileum.Dietary DCA alleviated the NE-induced ileal inflammation in a dose-dependent manner compared to NE control birds.Consistent with the increased histopathological scores,subclinical NE birds suffered body weight gain reduction compared to the uninfected birds,an effect attenuated with increased doses of dietary DCA.At the molecular level,the highest dose of DCA at 1.5 g/kg reduced C.perfringens luminal colonization compared to NE birds using PCR and FISH.Furthermore,the dietary DCA reduced subclinical NE-induced intestinal inflammatory gene expression and cell apoptosis using PCR and TUNEL assays.Upon further examining ileal bile acid pool through targeted metabolomics,subclinical NE reduced the total bile acid level in ileal digesta compared to uninfected birds.Notably,dietary DCA increased total bile acid and DCA levels in a dose-dependent manner compared to NE birds.Conclusion:These results indicate that DCA attenuates NE-induced intestinal inflammation and bile acid reduction and could be an effective antimicrobial alternative against the intestinal disease. | Mohit Bansal Ying Fu Bilal Alrubaye Mussie Abraha Ayidh Almansour Anamika Gupta Rohana Liyanage Hong Wang Billy Hargis Xiaolun Sun | 2020 | Journal of Animal Science and Biotechnology2020，11，3： | 3 |
| 3 | In-vitro antimicrobial activity screening of some ethnoveterinary medicinal plants traditionally used against mastitis,wound and gastrointestinal tract complication in Tigray Region,Ethiopia显示文摘Objective:To screen the antibacterial activity of nine ethnoveterinary plants traditionally used for the treatment of mastitis,wound and gastrointestinal complications.Methods:Hydroalcoholic exctracts of medicinal plants namely,Achyranthes aspera(A.aspera) L.(Family Asparagaceae),Ficus caria(F.caria)(Family Moraceae).Malvi parviflora(M.parviflora)(Family Malvaceae),Vernonia species(V.species) docal name Alakit.Family Asteraceae),Solatium hastifolium(S.hastifolium)(Family Solanaceae),Calpurinia aurea(C.aurea)(Ait) Benth(Family Fabaceae),Nicotiana tabacum(N.tabacum) L.(Family Solanaceae),Ziziphus spina-christi(Z.spina-christi)(Family Rhamnaceae).Croton macroslachys(C.macrostachys)(Family Fuphorhiaceae).were screened against clinical bacterial isolates of veterinary importance from October 2007 to April2009.The antibacterial activity was tested using disc diffusion at two concentrations(200 mg/mL and 100 mg/mL) and broth dilution methods using 70%methanol macerated leal extracts.Results:With the exception ol S.hastifolium all plant extracts exhibited antibacterial activity.Among the medicinal plants tested C.aurea.C.macrostachyus,A.aspera,N.tabacum and vcrnonia species(Alakit) showed the most promising antimicrobial properties.Conclusions:It can be concluded that many of the tested plants have antibacterial activity and supports the traditional usage of the plants for mastitis,wound and gastrointestinal complications treatment.Further studies into their toxicity and phytochemistry is advocated. | Shewit Kalayou Mekonnen Haileselassie Gebremedhin Gebre-egziabher Tsegay Tiku'e Samson Sahle Habtamu Taddele Mussie Ghezu | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，7： | 3 |
| 4 | Response to radiofrequency ablation of pulmonary tumours: a prospective, intention-to-treat, multicentre clinical trial (the RAPTURE study)显示文摘 | Riccardo Lencioni Laura Crocetti Roberto Cioni Robert Suh Derek Glenn Daniele Regge Thomas Helmberger Alice R Gillams Andrea Frilling Marcello Ambrogi Carlo Bartolozzi Alfredo Mussi | 2008 | Lancet Oncology2008，，7： | 2 |
| 5 | Surgical Treatment of Metastatic Tumors to the Pancreas: A Single Center Experience and Review of the Literature显示文摘 | Stefano Crippa MD Carlo Angelini MD Chiara Mussi Claudia Bonardi MD Fabrizio Romano MD Paola Sartori MD Franco Uggeri MD Giorgio Bovo MD | 2006 | World Journal of Surgery2006，，8： | 2 |
| 6 | Extended thymectomy in myasthenia gravis:a teamwork of neurologist,thoracic surgeon and anaesthesist may improve the outcome显示文摘 | Mussi A Lucchi M Murri L | 2001 | Eur J Cardiothorac Surg2001，19，： | 1 |
| 7 | Dermatofibrosarcoma protuberans treated at a single institution:a surgical disease with a high cure rate显示文摘 | Fiore M Miceli R Mussi C | 2005 | J Clin Oncol2005，23，30： | 1 |
| 8 | Loss of a 29-kilodalton outermembrane protein in Acinetobacter baumannii is associated with imipenem resistance显示文摘 | Limansky AS Mussi MA Viale AM | 2002 | Journal of Clinical Microbiology2002，40，12： | 1 |
| 9 | Acquistion of resistance to carbapeneras in multidrug-resistant clinical Strains of Aeinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of beta-barrel outer membrance proteins显示文摘 | Mussi MA Limansky AS Viale AM | 2005 | Antimicrob Agents Chemother2005，49，4： | 1 |
| 10 | A new method for the determination of Vitamin B12 in seawater 显示文摘 | Mussie Okbamichael Sergio A Sanudo-Wilhelmy | 2004 | Analytica Chimica Acta2004，517，： | 1 |
| 11 | Activation of D1/D5 dopa- mine receptors protects neurons from synapse dysfunction induced by amyloid-beta oligomers 显示文摘 | Jurgensen S Antonio LL Mussi GE | 2011 | J Biol Chem2011，286，5： | 1 |
| 12 | Sensitive EDTA-based microbiological assays for detection of metallo-{beta}-lactamases in nonfermentative gram-negative bacteria显示文摘 | Marchiaro P Mussi MA Ballerini V | 2005 | J Clin Microbiol2005，43，11： | 1 |
| 13 | Relationship between body composition and bone mineral content in young and elderlywomen显示文摘 | Bedogni G Mussi C Malavolti M | 2002 | Ann Hum Biol2002，29，5： | 1 |
| 14 | Sensitive EDTA-Based Microbiological Assays for Detection of Metallo-_-Lactamases in Nonfermentative Gram-Negative Bacteria显示文摘 | Marchiaro P Mussi MA Ballerini V | 2005 | J Clin Microbiol2005，43，11： | 1 |
| 15 | Surgical treatment of metastatic tumors to the pancreas: a single center experience and review of the literature显示文摘 | Crippa S Angelini C Mussi C | 2006 | World J Surg2006，30，： | 1 |
| 16 | Loss of a 29-kilodalton outermembrane protein in Acinetobacter baumannii is associated withimipenem resistance 显示文摘 | Limansky AS Mussi MA Viale AM | 2002 | J Clin Microbiol2002，40，12： | 1 |
| 17 | Loss of a29-kilodalton outer membrance protein in Acinetobacter baumannii is associated with imipenem resistance显示文摘 | LIMANSKY A S MUSSI M A VIALE A M | 2002 | J Clin Microbiol2002，40，12： | 1 |
| 18 | Diagnostic expert systems:a method for engineering knowledge used in sequential diagnosis显示文摘 | MUSSI S | 2000 | Expert Systems2000，17，4： | 1 |
| 19 | Retroperitoneal sarcoma: is it time to change the surgical policy? 显示文摘 | Mussi C Colombo P Bertuzzi A | 2011 | Ann Surg Oncol2011，18，8： | 1 |
| 20 | High speed simulation of discrete event systems by mixing process oriented and equational approaehes显示文摘 | Gaujal B Jean-Marie A Mussi P | 1997 | Parallel Computing1997，23，12： | 1 |
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