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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Real-time Fou- rier transformer based on fiber grating 显示文摘 | Muriel M A Azana J Carballar A | 1999 | Opt Lett1999，24，1： | 1 |
| 3 | Dendritic cell regulation of Th1-Th2 development 显示文摘 | Muriel M Kenneth MM | 2000 | Nat Immunol2000，1，： | 1 |
| 4 | Effects of short-term detraining on postprandial metabolism,endothelial function,and inflammation in endurance-trained men:dissociation between changes I triglyceride metabolism and endothelial function显示文摘 | Muriel JC Craig M | 2003 | J Clin Endol Met2003，88，9： | 1 |
| 5 | Divergent molecular mechanisms underlying the pleiotropic funcitionns of macrophage inhibitory cytokine-1 in cancer显示文摘 | Murielle M Surinder KB | 2010 | J Cell Physiol2010，224，3： | 1 |
| 6 | Security Issues in All-optical networks显示文摘 | DOUGLAS M RICHARD A | 1997 | IEEE Network Maga-zine1997，56，： | 1 |
| 7 | Mutations in the SPG3A gene encoding the GTPase atlastin interfere with vesicle trafficking in the ER/Golgi interface and Golgi morphogenesis显示文摘 | Namekawa M Muriel MP Janer A | 2007 | Mol Cell Neurosci2007，35，1： | 1 |
| 8 | Volatile compounds in iberian dry-cured loin显示文摘 | Muriel E Antequera T Petrón M J | 2004 | Meat Science2004，68，3： | 1 |
| 9 | Volatile compounds in Iberian drycured loin显示文摘 | Muriel E Antequeraa T Petrbn M J | 2004 | Meat Science2004，68，3： | 1 |
| 10 | An efficient inverse scattering algorithm for the design of nonuniform fiber Bragg gratings显示文摘 | Feced R Zervas M N Muriel M A | 1999 | IEEE J Quantum Electron1999，35，8： | 1 |
| 11 | Fatty acids and triacylglycerols profiles from different types of Iberian dry-cured hams 显示文摘 | PETRON M J MURIEL E TIMON M L | 2004 | Meat Science2004，68，： | 1 |
| 12 | Computing the solar vector显示文摘 | Blanco Muriel M Alarcon Padilla D C Lopea Moratalla T | 2001 | Solar Energy2001，70，5： | 1 |
| 13 | Morphomet- ric evaluation of changes in the digestive tract of rainbow trout (Oncorhynchus mykiss) due to fish meal replacement with soy protein concentrate 显示文摘 | ANNE-MARIE E SADASIVAM K MURIEL M | 2007 | Aquaculture2007，273，1： | 1 |
| 14 | Inhibition of mitochondrial respiration by nitric oxide is independent of membrane fluidity modulation or oxidation of sulfhydryl groups 显示文摘 | PEREZ-ROJAS J M MURIEL P | 2005 | J Appl Toxicol2005，25，6： | 1 |
| 15 | XORs in the air显示文摘 | Sachin Katti Hariharan Rahul Wenjun Hu Dina Katabi Muriel Médard Jon Crowcroft | 2008 | IEEE/ACM Transactions on Networking (TON)2008，，3： | 1 |
| 16 | Brusa-tol- induced HL-60 cell differentiation involves NF-kB activation显示文摘 | Muriel Cuendet Joell J Gills John M Pezzuto | 2004 | Canc Let2004，206，1： | 1 |
| 17 | An efficient inverse scattering algorithm for the design of nonuniform fiber Bragg gratings显示文摘 | Feced R Zervas M N Muriel M A | 1999 | IEEE J Quantum Electron1999，35，8： | 1 |
| 18 | Sociocultural Integration in Mergers and Acquisitions: Unresolved Paradoxes and Directions for Future Research显示文摘 | Günter K. Stahl Duncan N. Angwin Philippe Very Emanuel Gomes Yaakov Weber Shlomo Yedidia Tarba Niels Noorderhaven Haim Benyamini Dave Bouckenooghe Samia Chreim Muriel Durand Mélanie E. Hassett Gary Kokk Mark E. Mendenhall Nicola Mirc Christof Miska Kathle | 2013 | Thunderbird Int’l Bus Rev2013，，4： | 1 |
| 19 | A random linear network coding approach to multicast显示文摘 | Tracey H Muriel M'E Ralf K | 2006 | IEEE Transactions on Information Theory2006，52，10： | 1 |
| 20 | Prevention by silymarin of membrane alterations in acute CC14 liver damage 显示文摘 | Muriel P Mourelle M | 1990 | Journal of Applied Toxicology1990，10，4： | 1 |
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